Absence of High-Risk Human Papillomavirus (HPV) Detection in Endocervical Adenocarcinoma with Gastric Morphology and Phenotype

Kusanagi, Yasuki; Kojima, Atsumi; Mikami, Yoshiki; Kiyokawa, Takako; Sudo, Tamotsu; Yamaguchi, Satoshi; Nishimura, Ryuichiro

doi:10.2353/ajpath.2010.100323

Cited by 134 publications

(88 citation statements)

References 43 publications

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“…is higher than previously reported (20,21). Kusanagi et al reported that HPV has been rarely detected in some types of adenocarcinoma of the uterus cervix (31). The present study included a larger number of patients (25.3%) with adenocarcinoma.…”

Section: Discussioncontrasting

confidence: 54%

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Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer

et al. 2017

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Abstract. Human papillomavirus (HPV) infection is well known as a major etiological risk factor associated with carcinogenesis in uterine cervical cancer. However, few reports have investigated the association between HPV genotype and outcome in patients with uterine cervical cancer following radiotherapy (RT). The aim of the present study was to investigate the association between the HPV genotype and clinical outcome following RT in Japanese patients with uterine cervical cancer. Between November 2001 and August 2006, 157 Japanese women with uterine cervical cancer were treated with RT or concurrent chemoradiotherapy with curative intent. Pretreatment, formalin-fixed, paraffin-embedded biopsies were obtained from 83 patients. HPV genotypes were determined using the polymerase chain reaction method. Patients were categorized, according to HPV L1 protein sequence homology, into the HPV α-9 (HPV 16,31,33, 52, and 58),39, 45, 59, and 68) or 'other' (HPV 51 and 56) groups. Associations between HPV genotype and clinical outcome following RT were evaluated. A total of 54 (65.1%) tumors were HPV α-9-positive, 13 (15.7%) were HPV α-7-positive, 2 (2.4%) were categorized under 'other' and 14 (16.9%) were HPV-negative. There were no significant differences in age, FIGO stage, regional lymph node metastases rate at diagnosis, or concurrent chemotherapy administration between the HPV α-9 and α-7 groups. The median follow-up period was 52 months (range, 2-156 months). The 5-year disease-free survival rates were 54.5 and 30.8% in the HPV α-9 and α-7 groups, respectively (P=0.034), and the 5-year distant metastasis rates were 38.0 and 69.2%, respectively (P=0.015). There were no significant differences in the 5-year local control or overall survival (OS) rates between the two groups. HPV genotype affected the 5-year distant metastatic rate, however not the 5-year local control or OS rate in patients with uterine cervical cancer following RT. IntroductionUterine cervical cancer (CC) is the second most common cancer among women, worldwide (1). The annual global incidence of CC in 2012 was 528,000 cases, and the annual global mortality rate was 266,000 deaths, with 85% of cases occurring in developing countries, where CC is a leading cause of cancer-related death in women (2). Oncogenic type human papillomavirus (HPV) infection is a major etiologic risk factor (3) associated with carcinogenesis (4). More than 100 HPV types have been identified, with a subset of these being classified as high risk. HPV 16 and HPV 18 are the most commonly detected genotypes occurring in 71% of invasive CCs (5). Current detection methods have uncovered a HPV prevalence of 95-100% in women with CC (6,7).The primary treatment strategy for uterine CC consists of surgery or radiotherapy (RT). Surgery is typically reserved for early-stage disease and small lesions including stage IA, IB1, and selected IIA1 diseases (8). Based on the results of randomized clinical trials, concurrent chemoradiotherapy (CCRT) has become the primary treatment for stage IB2...

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Section: Discussioncontrasting

confidence: 54%

“…HPV genotypes were determined using the polymerase chain reaction method. Patients were categorized, according to HPV L1 protein sequence homology, into the HPV α-9 (HPV 16,31,33, 52, and 58),39, 45, 59, and 68) or 'other' (HPV 51 and 56) groups. Associations between HPV genotype and clinical outcome following RT were evaluated.…”

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Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer

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“…22 Mucinous carcinoma has a known noninvasive precursor lesion, lobular endocervical glandular hyperplasia ( Figure 13). In histologic specimens, mucinous carcinoma commonly presents as tall mucin-producing glands penetrating the cervical wall with minimal if any stromal reaction and minimal cytologic atypia, hence the synonyms 'adenoma malignum' or 'minimal-deviation adenocarcinoma'…”

Section: Invasive Endocervical Adenocarcinomamentioning

confidence: 99%

Practical issues related to uterine pathology: in situ and invasive cervical glandular lesions and their benign mimics: emphasis on cytology–histology correlation and interpretive pitfalls

Wilbur

2016

Modern Pathology

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In situ and invasive neoplastic glandular lesions of the uterine have cytologic correlates that must be distinguished from a variety of benign and reactive conditions. Careful study of the cytologic features allows discrimination in the majority of cases; however, the designation of 'atypical glandular cells' is reserved for equivocal cases that cannot be readily resolved. In this article, the cytologic features of endocervical adenocarcinoma in situ and invasive endocervical adenocarcinoma will be presented, highlighting their correlation to the well-known histologic features. Variants of the usual type of endocervical neoplasms that have important clinical and differential diagnostic features, including mucinous adenocarcinoma and clear-cell carcinoma, will be discussed. There are a number of common cytologic mimics of endocervical neoplasms, including tubal metaplasia, directly sampled (abraded) endometrium, and high-grade squamous intraepithelial lesion involving endocervical glands. The cytologic features of these entities and their differentiation from endocervical neoplasia will be explored. Finally, the role of ancillary studies such as human papillomavirus testing in the management of glandular lesions of the cervix will be integrated into the discussion.

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“…The former, which represent the vast majority, are referred to as endocervical adenocarcinomas of usual type and the latter are dominated by the gastric-type mucinous adenocarcinomas, which include minimal deviation adenocarcinoma. [1][2][3][4][5][6][7][8] Both types pose a number of diagnostic challenges for practicing pathologists. The most commonly encountered diagnostic problems include the following: (1) diagnosing invasion for high-risk HPV-related (usual type) endocervical adenocarcinomas of usual type, particularly for the common well differentiated and often superficial forms which must be distinguished from extensive endocervical adenocarcinoma in situ (AIS); (2) distinguishing high-risk HPV-related endocervical adenocarcinomas from endometrial endometrioid carcinomas and their related subtypes, which include those with mucinous and metaplastic-type differentiation; and (3) distinguishing benign mucinous endocervical glandular proliferations, including the various forms of endocervical glandular hyperplasia, from gastric-type mucinous endocervical adenocarcinomas, particularly the very well differentiated minimal deviation type.…”

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confidence: 99%

“…These adenocarcinomas are characterized by glands lined by cells with abundant pale to eosinophilic cytoplasm and distinct cell borders, with evident malignant cytologic features (vesicular nuclei often with prominent nucleoli), and vary from well to poorly differentiated (Figures 10a-d). 3,6,7,19 Minimal deviation adenocarcinomas (adenoma malignum) represent the highly differentiated form of this tumor. 20 They are characterized by numerous deceptively bland glands, which often lack surrounding stromal desmoplasia.…”

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confidence: 99%

Endocervical adenocarcinoma: selected diagnostic challenges

Ronnett

2016

Modern Pathology

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Endocervical adenocarcinomas can be classified into two main types of tumors, namely, those related to high-risk human papillomavirus and those unrelated to high-risk human papillomavirus. The former, representing the vast majority, are referred to as endocervical adenocarcinomas of usual type and the latter are dominated by the gastric-type mucinous adenocarcinomas. Commonly encountered diagnostic problems concerning these endocervical adenocarcinomas include: (1) diagnosing invasion for endocervical adenocarcinomas of usual type, particularly superficial forms which must be distinguished from extensive endocervical adenocarcinoma in situ; (2) distinguishing high-risk human papillomavirus-related endocervical adenocarcinomas from endometrial endometrioid carcinomas; and (3) distinguishing benign/hyperplastic mucinous endocervical glandular proliferations from gastric-type mucinous endocervical adenocarcinomas, particularly minimal deviation adenocarcinoma. The current review provides practical points and numerous illustrative examples to guide pathologists in addressing these diagnostic challenges in routine practice.

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Absence of High-Risk Human Papillomavirus (HPV) Detection in Endocervical Adenocarcinoma with Gastric Morphology and Phenotype

Cited by 134 publications

References 43 publications

Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer

Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer

Practical issues related to uterine pathology: in situ and invasive cervical glandular lesions and their benign mimics: emphasis on cytology–histology correlation and interpretive pitfalls

Endocervical adenocarcinoma: selected diagnostic challenges

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