Absence of HHV-6 and HHV-7 in cerebrospinal fluid in relapsing-remitting multiple sclerosis

Abstract

Our data suggest that there is no relationship between HHV-6 or HHV-7 and MS.

B cells in multiple sclerosis

“…Other reports do not support an association between HHV-6 and MS. One study found serum IgM responses to HHV-6 in only 1 of 55 MS patients, and IgG responses in 15 of the patients (94). Using PCR, other groups have not detected HHV-6 in MS, and have not shown HHV-6 antibody titers different from those in controls (95,96). Furthermore, no EBV-specific RNA was detected in 10 MS brains by in situ hybridization (97).…”

Human Herpesvirus 6 Infection as a Trigger of Multiple Sclerosis

“…39,58 Of the studies classified as B quality, 1 study reached statistical significance, 44 whereas 8 studies did not. 23,47,[59][60][61][62]67,68 In most B-quality studies, a greater proportion of MS patients had detectable HHV-6 DNA in their PBMCs than controls; however, the results were not statistically signifi-For personal use. Mass reproduce only with permission from Mayo Clinic Proceedings a .…”

“…Nine studies had severe methodological issues, were classified as C quality, and found no statistically significant difference between MS patients and controls 22,23,[29][30][31][32] (Ablashi et al, 22 Friedman et al, 32 and Taus et al 23 on both CSF IgG and IgM correlations).…”

“…20,[24][25][26] One of those studies considered mean antibody titers, 20 and another reported only that the IgG titers of MS patients were higher than those of controls without providing absolute values. 24 The remaining 7 studies were classified as lower quality (C), mostly because of a failure to define and provide details about the study patients with MS. [21][22][23]27,[29][30][31] According to the CTF classification, 18 of the 18 studies were classified as quality II-1.…”

“…[21][22][23]27,31,32 All of the IgM studies were classified as quality II-1 on the basis of the CTF criteria.…”