Absence of Graft‐versus‐leukaemia (Gvl) Effect by Leucocytes Transfused: A Prospective Randomized Trial in Acute Myeloid Leukaemia (Aml) Patients

Norol, Françoise; Parquet, Nathalie; Kuentz, Mathieu; Bierling, Philippe; Cordonnier, Charlotte; Beaujean, F; Duedari, N; Jp, Vernant

doi:10.1111/j.1365-2141.1991.tb04509.x

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…Theoreti cally, the introduction of immune competent T lymphocytes via transfusion of blood products could cause a GVL effect in nontransplanted leukemic patients. However, contradic tory reports exist in the literature supporting on this point [90][91][92][93]. In patients receiving filtered blood components a longer leukemia-free survival was observed, which was due to the prevention of HLA sensitization and a platelet refrac tory state [94].…”

Section: Graft-versus-leukeniia Effectmentioning

confidence: 93%

Immunologic Consequences of Blood Transfusion and Their Clinical Manifestations

Petranyi

Réti

Harsányi

et al. 1997

Int Arch Allergy Immunol

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Aspects of clinical immunology, in the context of transfusion medicine, became highlighted in the last decade as a consequence of the accelerating expansion of basic immunology, immunogenetics and molecular biology. In addition sophisticated new technologies, which were capable of producing pure and safe blood products, attracted more attention to research and monitor the consequences of transfusion. These technologies also had obvious effects on supportive hematological therapy. The transfusion of blood components follows the rules of organ transplantation: when there is a mismatch between the donor and the recipient, the transfusion has the potential to induce various kinds of immune response against alloantigens. Antigen-compatible transfusions that involve major and rare blood groups are in almost all cases mismatched with respect to various polymorphic systems expressed on the cellular blood components. These include histocompatibility leukocyte antigens (HLA), tissue-specific and differentiation alloantigens, and, in the case of plasma, immunoglobulins, complement components, heat shock proteins, and shedded soluble membrane alloantigens. Clinical manifestations of alloimmune responses are typically deleterious. For example, immediate antigen-antibody binding and its consequences as secondary activations are paralleled by the nonhaemolytic febrile reaction, HLA sensitization can lead to a state of platelet refractoriness and inconvenient clinical symptoms. In certain immunogenetic situations and in immunodeficient patients graft-versus-host disease can be induced by blood products that contain live lymphocytes. Leukocyte filtration techniques are widely used to avoid most but not all of these harmful side effects of blood component therapy. In contrast to these harmful side effects in certain immunogenetic conditions, alloantigens that are expressed on various blood products can elicit an advantageous suppression of the immune response in the recipient. In the context of kidney transplantation this is termed the ‘beneficial transfusion effect’, and typically results in the prolongation of the graft’s survival. In cases of recurrent habitual abortion and IgG therapy associated with certain autoimmune diseases, immunization with leukocytes specifically takes advantage of this phenomenon. To date the beneficial transfusion effect is not fully understood. In certain cases of malignancies or gastrointestinal surgeries this suppression of immune regulation that is induced by transfusion can worsen the clinical state either by permitting the spread of the tumor or by allowing severe infections to proceed unchecked. In conclusion it is imperative to monitor the immunological consequences of transfusion in order to deter the disadvantageous side effects. Taking advantage of the ‘beneficial transfusion effect’ may also provide a new means for immune therapy using the various blood products.

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Section: Graft-versus-leukeniia Effectmentioning

confidence: 93%

Immunologic Consequences of Blood Transfusion and Their Clinical Manifestations

Petranyi

Réti

Harsányi

et al. 1997

Int Arch Allergy Immunol

View full text Add to dashboard Cite

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Section: Leucodepletion and Disease Remission In The Treatment Of Acumentioning

confidence: 94%

“…Tucker et al( 1 989) reported that the duration of remission was shorter in patients receiving leucodepleted blood components. Other teams (Lopez et al, 1990; Rebulla et al 1990;Norol et al 1991; van Marwijk Kooy et al 1991) have not observed this effect, but the patient groups have been small and not uniformly treated.The FRC Blood Transfusion Service has, since 1985, prepared leucodepleted components with less than 1 x lo6 leucocytes/unit. In 1986, the Finnish Leukaemia Group organized national treatment trials for AML and ALL.…”

mentioning

confidence: 93%