Absence of farnesol salvage in
Candida albicans
and probably in other fungi
Adam Voshall,
Daniel J. Gutzmann,
Ignasi Bofill Verdaguer
et al.
Abstract:Farnesol salvage, a two-step pathway converting farnesol to farnesyl pyrophosphate (FPP), occurs in bacteria, plants, and animals. This paper investigates the presence of this pathway in fungi. Through bioinformatics, biochemistry, and physiological analyses, we demonstrate its absence in the yeasts
Saccharomyces cerevisiae
and
Candida albicans
, suggesting a likely absence across fungi. We screened 1,053 fungal genomes, including 34 from
C.… Show more
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