Absence of embryotoxic effects from low-level (nonthermal) exposure of rats to 100 MHz radiofrequency radiation.

Lary, Joseph M.; Conover, David L.; Johnson, Peggy H.

doi:10.5271/sjweh.2434

Cited by 19 publications

(6 citation statements)

References 4 publications

(4 reference statements)

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“…The authors ascribed those effects to the hyperthermia induced by the RFEMF. Lary et al [1983b] exposed pregnant rats to 100 MHz RFEMF within a transverse electromagnetic (TEM) cell at 25 mW/cm 2 for more than 6 h per day on gestation days 6-11. The mean whole body SAR was about 0.4 W/kg.…”

Section: Ratsmentioning

confidence: 99%

Radiofrequency fields and teratogenesis

Heynick

Merritt

2003

Bioelectromagnetics

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Experimental studies that sought teratologic effects or developmental abnormalities from exposure to radiofrequency electromagnetic fields (RFEMF) in the range 3 kHz-300 GHz are critically reviewed for their possible consequences on human health. Those studies were conducted on beetles, birds, rodents, and nonhuman primates. Collectively, those experimental studies indicate that teratologic effects can occur only from exposure levels that cause biologically detrimental increases in body temperature. No reliable experimental evidence was found for nonthermal teratologic effects; rodents, mouse fetuses, and perinatal mice are more susceptible to such effects than rats. The primary confirmed effect in rats at high RFEMF levels was initial weight deficits in fetuses and neonates that decreased with infant growth. More generally from findings with pregnant mammals, exposures at RFEMF levels far higher than those permitted under the IEEE human exposure guidelines are necessary to reach or exceed cited experimental thresholds for maternal temperature increases. Some results indicated that the levels necessary to cause such effects in pregnant mammals could exceed those lethal to the dams. In a behavioral study of squirrel monkeys, no effects were observed on usual dam-offspring interactions or EEGs, but unexpected deaths of a number of offspring had occurred. However, this finding was not confirmed in a study solely on infant death using a larger number of subjects for greater statistical validity. Also reviewed were epidemiologic studies of various human populations considered to have been chronically exposed to environmental levels of RFEMF. Early studies on the incidence of congenital anomalies yielded no credible evidence that chronic exposure of pregnant women or of fathers exposed to RFEMF from nearby sources at levels below those guidelines would cause any anomalies in their offspring. The findings of studies on pregnancy outcomes of female physiotherapists occupationally exposed while treating patients with RFEMF were mixed, but taken collectively, the findings were negative. Bioelectromagnetics Supplement 6:S174-S186, 2003.

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Section: Ratsmentioning

confidence: 99%

Radiofrequency fields and teratogenesis

Heynick

Merritt

2003

Bioelectromagnetics

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“…One of the first evidence of teratogenicity, due to RFR in SD rats was that showed by Lary et al in the early 1980s using low, non-thermal exposure level, with results in contrast with other findings from the same authors [60]. For investigating possible embryotoxic effects, in this study, pregnant SD rats were irradiated with 27.12 MHz RFR on gestation day 9 at an approximately SAR value of 11 W/kg.…”

Section: Reproductive/developmental Toxicity In Vivo Investigationsmentioning

confidence: 90%

“…Irradiated rats did not differ in the percentage number of malformed fetuses, implantations per litter, percentage of implantations dead or resorbed, fetal weight, fetal crown-rump length, or fetal sex ratio, compared to untreated (sham-exposed) rats. The results showed a lack of embryotoxic or teratogenic effect in rats at the maximum permissible RFR exposure level following the 1982 ANSI recommendations [60].…”

Section: Reproductive/developmental Toxicity In Vivo Investigationsmentioning

confidence: 99%

The Contribution of In Vivo Mammalian Studies to the Knowledge of Adverse Effects of Radiofrequency Radiation on Human Health

Vornoli

Falcioni

Mandrioli

et al. 2019

IJERPH

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The proliferation of cellular antennas and other radiofrequency radiation (RFR) generating devices of the last decades has led to more and more concerns about the potential health effects from RFR exposure. Since the 2011 classification as a possible carcinogen by the International Agency for Research on Cancer (IARC), more experimental studies have been published that support a causal association between RFR exposure and health hazards. As regard cancer risk, two long-term experimental studies have been recently published by the US National Toxicology Program (NTP) and the Italian Ramazzini Institute (RI). Despite important experimental differences, both studies found statistically significant increases in the development of the same type of very rare glial malignant tumors. In addition to carcinogenicity, reproductive organs might be particularly exposed, as well as sensitive to RFR. In this work, we reviewed the currently available evidence from in vivo studies on carcinogenicity and reproductive toxicity studies in order to summarize the contribution of experimental research to the prevention of the adverse effects of RFR on human health.

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“…Jensh et al (1983) exposed pregnant rats to 20 mW/cm 2 at frequency 2450 MHz and Lary et al (1983) exposed pregnant rats to 100 MHz and power density of 25 mW/cm 2 and they observed no significant alterations in fetal development.…”

Section: Morphological Studiesmentioning

confidence: 95%

Effect Of Microwave Radiation On The Retina Of Mice Embryos

Amer

Shabaka

Zakaria

et al. 2013

JBLS

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The present investigation is concerned with the effect of mobile phone radiation on the development of mice embryos. The pregnant females were divided into 3 groups, the control group (GI) and 2 irradiated groups, 10 females each. The 2 nd group and 3 rd group were subjected to 950MHz at SAR=1W/kg and 1800MHz at SAR=1.6W/kg respectively from day 7 to day 14 of gestation for 2 hours/ day. The exposure to microwave caused fetal growth retardation in all irradiated groups. However, no morphological abnormalities were observed in all the experimental groups.The retina of the 18-days-old fetus maternally exposed to microwave showed histopathological changes including pyknotic nuclei in both outer and inner nuclear layers (group II), while they lost their normal arrangement and became aggregated in the outer nuclear layer in group III. At ISSN 2157-6076 2013 www.macrothink.org/jbls 216 the level of electron microscopy the retinal tissue revealed deformed and dilated mitochondria and condensed heterochromatin of the nuclei of the outer nuclear layer. The ganglionic cells showed degenerated cytoplasmic organelles in group II. However, remarkable aggregations of melanin pigments were detected in the pigmented layer of group III. Since the evaluation of the clinical relevance of microwave radiation interactions on fetal retina is still lacking, such pathological changes must be taken into consideration in order to minimize cell injuries. Journal of Biology and Life Science

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Absence of embryotoxic effects from low-level (nonthermal) exposure of rats to 100 MHz radiofrequency radiation.

Cited by 19 publications

References 4 publications

Radiofrequency fields and teratogenesis

Radiofrequency fields and teratogenesis

The Contribution of In Vivo Mammalian Studies to the Knowledge of Adverse Effects of Radiofrequency Radiation on Human Health

Effect Of Microwave Radiation On The Retina Of Mice Embryos

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