Absence of effect of adjuvant growth hormone therapy on follicular responses to exogenous gonadotropins in women: normal and poor responders

Shaker, Adel; Fleming, Richard; Jamieson, M.E.; Yates, R.W.S.; Coutts, J. R. T.

doi:10.1016/s0015-0282(16)55435-1

Cited by 50 publications

(13 citation statements)

References 15 publications

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“…GH therapy does not, however, enhance gonadotrophic responsiveness in all women with infertility (Shaker et al 1992, Tapanainen et al 1992, Younis et al 1992. Most of the women that do respond to GH-hMG co-treatment have an impairment in their secretion of GH (Blumenfeld et al 1991).…”

Section: Figurementioning

confidence: 99%

“…The infertility in these women may thus result in part from relative GH deficiency, whereas other dysfunctions are likely to be causal in the infertility of women that fail to respond to GH-hMG co-treatment (Blumenfeld et al 1991). GH responsiveness is also greatest in young, hypo-oestrogenic women who have been subjected to previous pituitary suppression (Shaker et al 1992, Tapanainen et al 1992, Younis et al 1992, Blumenfeld & Amit 1993. Conversely, GH therapy is largely ineffective in hypergonadotrophic women (Homburg & Farhi 1995) or women experiencing incipient or current ovarian failure (Homburg et al 1991).…”

Section: Figurementioning

confidence: 99%

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Growth hormone: roles in female reproduction

Hull¹,

Harvey²

2001

Journal of Endocrinology

195

128

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GH, as its name suggests, is obligatory for growth and development. It is, however, also involved in the processes of sexual differentiation and pubertal maturation and it participates in gonadal steroidogenesis, gametogenesis and ovulation. It also has additional roles in pregnancy and lactation. These actions may reflect direct endocrine actions of pituitary GH or be mediated by its induction of hepatic or local IGF-I production. However, as GH is also produced in gonadal, placental and mammary tissues, it may act in paracrine or autocrine ways to regulate local processes that are strategically regulated by pituitary GH. The concept that GH is an important modulator of female reproduction is the focus of this review.

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Growth hormone: roles in female reproduction

Hull¹,

Harvey²

2001

Journal of Endocrinology

195

128

View full text Add to dashboard Cite

show abstract

“…Accordingly reduced age at menopause has been hypothesized for these women as a long-term consequence of having a smaller pool of primordial follicles [5]. In recent years, authors who have tried to define criteria for identifying POR have referred to variables such as: a peak E2 level of <300 pg/ml to <500 pg/ml [6,7], requirement for an increased daily [8] or total gonadotropin stimulation dose [9] or previous cancelled cycle due to a poor response [10]. Although the number of developing follicles and/or the number of oocytes retrieved after a standard dose of ovarian stimulation are two of the most frequent criteria used, the suggested cut-offs have often varied [7,11,12].…”

Section: Introductionmentioning

confidence: 99%

Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study

Marca

Grisendi

Giulini

et al. 2015

J Assist Reprod Genet

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Purpose to compare the baseline characteristics and chance of live birth in the different categories of poor responders identified by the combinations of the Bologna criteria and establish whether these groups comprise a homogenous population. Methods database containing clinical and laboratory information on IVF treatment cycles carried out at the Mother-Infant Department of the University Hospital of Modena between year 2007 and 2011 was analysed. This data was collected prospectively and recorded in the registered database of the fertility centre. Eight hundred and thirty women fulfilled the inclusion/ exclusion criteria of the study and 210 women fulfilled the Bologna criteria definition for poor ovarian response (POR). Five categories of poor responders were identified by different combinations of the Bologna criteria. Results There were no significant differences in female age, AFC, AMH, cycle cancellation rate and number of retrieved oocytes between the five groups. The live birth rate ranged between 5.5 and 7.4 % and was not statistically different in the five different categories of women defined as poor responders according to the Bologna criteria. Conclusion The study demonstrates that the different groups of poor responders based on the Bologna criteria have similar IVF outcomes. This information validates the Bologna criteria definition as women having a uniform poor prognosis and also demonstrates that the Bologna criteria poor responders in the various subgroups represent a homogenous population with similar pre-clinical and clinical outcomes.

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“…In contrast, recent prospective studies have challenged the hypothesis that GH is involved in augmenting the ovarian responses to FSH in women [105][106][107][108]. In normal and poor responders undergoing IVF, neither follicular recruitment, E2 secretion by mature follicles, nor oocyte yield and quality are affected by GH treatment.…”

Section: Igf Responses During Ovulation Induction Igf I During Gh Trementioning

confidence: 99%

“…The lack of clinical efficiency of GH could result from the parallel increases in IGFBPs, along with IGF-I. The significant interpatient difference in the follicular fluid IGFBP responses to GH may additionally offer an explanation for the differences in clinical response to GH among published series [22, [92][93][94][105][106][107].…”

Section: Igf Responses During Ovulation Induction Igf I During Gh Trementioning

confidence: 99%

Clinical Implications of Insulin-Like Growth Factors and Their Binding Proteins in Reproduction.

Yoshimura

2000

Endocr J

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Absence of effect of adjuvant growth hormone therapy on follicular responses to exogenous gonadotropins in women: normal and poor responders

Cited by 50 publications

References 15 publications

Growth hormone: roles in female reproduction

Growth hormone: roles in female reproduction

Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study

Clinical Implications of Insulin-Like Growth Factors and Their Binding Proteins in Reproduction.

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