Absence of Cross-Reactivity to Myeloperoxidase of Anti-Thyroid Microsomal Antibodies in Patients with Autoimmune Thyroid Diseases

Freire, Beatriz A.; Paula, Ingrid Dick de; Paula, Francisco José Albuquerque de; Queluz, Thais Thomaz; Kallenberg, Cees G. M.; Limburg, Pieter C.

doi:10.1097/00000441-200102000-00001

Cited by 17 publications

(9 citation statements)

References 15 publications

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“…In a previous study on the induction of ANCA by minocycline, sulfasalazine, and penicillamine, we showed that when ANCA were present in patients after treatment with these drugs, they had already been present prior to treatment start (38). The presence of MPO ANCA may also be explained by the presence of anti-TPO antibodies that given the partial homology between both proteins, may crossreact with MPO (39), although this has been disputed by others (40). In our patients, the presence of MPO ANCA was not related to anti-TPO antibodies.…”

Section: Discussionmentioning

confidence: 95%

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Slot¹,

Links²,

Stegeman³

et al. 2005

Arthritis & Rheumatism

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Section: Discussionmentioning

confidence: 95%

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Slot¹,

Links²,

Stegeman³

et al. 2005

Arthritis & Rheumatism

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“…ID also lowers the activity of other heme-containing enzymes, such as cytochrome oxidase and myeloperoxidase (MPO) (3), and therefore one might speculate that women with ID develop antibodies against MPO more easily, leading to a cross-reaction with TPO-abs and subsequently explaining the higher prevalence of TAI (22). In a more recent paper, the cross-reactivity hypothesis could however not be confirmed (23). Data on the prevalence of TAI in pregnant women after iodine fortification (like the fortification program in Denmark) taught us that the prevalence of TAI increased 10 years later (24).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered?

Veltri¹,

Decaillet²,

Kleynen³

et al. 2016

European Journal of Endocrinology

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Objective: Thyroid disorders and iron deficiency (ID) are associated with obstetrical and fetal complications. Iron is essential for the normal functioning of thyroid peroxidase (TPO-abs) and ID is frequent during pregnancy. The aim of this study was to compare the prevalence of thyroid autoimmunity (TAI) and dysfunction during the first trimester of pregnancy in women with and without ID. Design: Cross-sectional data analysis of 1900 pregnant women nested within an ongoing prospective collection of pregnant women's data. Method: The study was performed in a single, tertiary referral center. During the first antenatal visit, ferritin, TPO-abs, thyroid-stimulating hormone (TSH) and free T 4 (FT 4 ) were measured and age and BMI were recorded. ID was defined as ferritin <15 µg/L, TAI when TPO-abs was >60 kIU/L, and subclinical hypothyroidism (SCH) when TSH was >2.5 mIU/L. Results: ID was present in 35% of women. Age and BMI were comparable between both groups. In the ID group, the prevalence of TAI and SCH was significantly higher, compared with that in the non-ID group (10% vs 6% and 20% vs 16%; P = 0.011 and 0.049 respectively). Ferritin was inversely correlated with serum TSH (ρ = −0.076; P = 0.001) and positive with FT 4 levels (ρ = 0.112; P < 0.001). In the logistic regression model, ID remained associated with TAI after correction for confounding factors (P = 0.017). The association with SCH was absent after correction for the confounders in the logistic regression model (P = 0.082), but remained present in the linear regression model (P = 0.035). Conclusions: ID was frequent during the first trimester of pregnancy and was associated with a higher prevalence of TAI, higher serum TSH, and lower FT 4 levels.

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“…These patterns are not antigen specific and reflect the fixation and staining of antigenic material. A c-ANCA is usually but not always due to a specific serine proteinase 3 and a p-ANCA pattern can result from a number of different target antigens such as elastase, cathepsin G, thyroperoxidase and lactoferrin [11,12]. In order to avoid interpretation problems, antigen specific ELISAs are used specifically to test for myeloperoxidase (MPO) and proteinase 3.…”

Section: Discussionmentioning

confidence: 99%

Atypical p-ANCA is not a poor prognostic marker in Postinfectious Glomerulonephritis

et al. 2007

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Postinfectious glomerulonephritis (PIGN) most commonly follows streptococcal infection. Antineutrophil cytoplasmic antibodies (ANCA) are characteristically negative in PIGN. We report on five cases who had positive atypical pANCA at presentation. The outcome was typical of other cases of PIGN with complete resolution of the glomerulonephritis in all five patients. Atypical pANCA occurs in a number of inflammatory conditions and antigenic targets may include proteins other than myeloperoxidase or proteinase 3. The presence of atypical p-ANCA does not indicate a poor prognosis.

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Absence of Cross-Reactivity to Myeloperoxidase of Anti-Thyroid Microsomal Antibodies in Patients with Autoimmune Thyroid Diseases

Cited by 17 publications

References 15 publications

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered?

Atypical p-ANCA is not a poor prognostic marker in Postinfectious Glomerulonephritis

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