Absence of CD71 Transferrin Receptor Characterizes Human Gastric Adenosquamous Carcinoma Stem Cells

Ohkuma, Masahisa; Haraguchi, Naotsugu; Ishii, Hideshi; Mimori, Koshi; Tanaka, Fumiaki; Kim, Ho Min; Shimomura, Miho; Hirose, Hajime; Yanaga, Katsuhiko; Mori, Masaki

doi:10.1245/s10434-011-1739-7

Cited by 53 publications

(32 citation statements)

References 34 publications

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“…These include cluster of differentiation 44 (CD44, and its variants); CD24/CD44; CD54/CD44; CXCR4; epithelial cell adhesion molecule (EpCAM)/CD44; aldehyde dehydrogenase 1 (ALDH1); CD90; CD71‐negative; CD133; CD166; leucine‐rich, repeat‐containing, G‐protein–coupled receptor 5 (LGR5), Oct4; and sex‐determining region Y‐box 2 (Sox2). Table 1 lists examples of the CSC markers that have been studied in gastric cancer 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35. When CSCs are positive for several of these markers, the cells display a phenotype of tumorigenicity and chemoresistance.…”

Section: Cancer Stem Cellsmentioning

confidence: 99%

Identifying and targeting cancer stem cells in the treatment of gastric cancer

Bekaii‐Saab

El‐Rayes²

2017

Cancer

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Current treatment regimens for gastric cancer are not adequate. Cancer stem cells (CSCs) may be a key driving factor for growth and metastasis of this tumor type. In contrast to the conventional clonal evolution hypothesis, CSCs can initiate tumor formation, self‐renew, and differentiate into tumor‐propagating cells. Because gastric cancer can originate from CSCs, it is necessary to review current targets of signaling pathways for CSCs in gastric cancer that are being studied in clinical trials. These pathways are known to regulate the self‐renewal and differentiation process in gastric CSCs. A better understanding of the clinical results of trials that target gastric CSCs will lead to better outcomes for patients with gastric cancer. Cancer 2017;123:1303–1312. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Section: Cancer Stem Cellsmentioning

confidence: 99%

Identifying and targeting cancer stem cells in the treatment of gastric cancer

Bekaii‐Saab

El‐Rayes²

2017

Cancer

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“…CD71 (also known as the transferrin receptor) is a membrane protein highly expressed on myocytes, keratinocytes, hepatocytes, pancreatic cells, and erythroid precursors, with a physiological role in mediating the uptake of transferrin-iron complexes. CD71 has been proposed as a negative selection marker, with the CD71-negative subpopulation of a gastric cancer cell line displaying chemoresistance, self-renewal, heterogeneous lineage, and increased tumorigenicity in mouse models [94].…”

Section: Other Potential Csc Markersmentioning

confidence: 99%

Gastric cancer stem cells: evidence, potential markers, and clinical implications

et al. 2015

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Gastric cancer is a significant global health problem. It is the fifth most common cancer and third leading cause of cancer-related death worldwide (Torre et al. in CA Cancer J Clin 65(2):87-108, 2015). Despite advances in treatment, overall prognosis remains poor, due to tumour relapse and metastasis. There is an urgent need for novel therapeutic approaches to improve clinical outcomes in gastric cancer. The cancer stem cell (CSC) model has been proposed to explain the high rate of relapse and subsequent resistance of cancer to current systemic treatments (Vermeulen et al. in Lancet Oncol 13(2):e83-e89, 2012). CSCs have been identified in many solid malignancies, including gastric cancer, and have significant clinical implications, as targeting the CSC population may be essential in preventing the recurrence and spread of a tumour (Dewi et al. in J Gastroenterol 46(10):1145-1157, 2011). This review seeks to summarise the current evidence for CSC in gastric cancer, with an emphasis on candidate CSC markers, clinical implications, and potential therapeutic approaches.

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“…In other studies, CD90 [36] , CD71 [37] , and CD133, ABCB1 and ABCG2 [38] , were identified as GCSC markers using human GC tissues or GC cell lines. Recently, Nagano et al [39] indicated that CD44 variant isoform (CD44v) is also one of the cell surface markers of GCSCs.…”

Section: Gastric Cancer Stem Cellsmentioning

confidence: 90%

The Role of Cancer-associated Fibroblasts in the Stemness of Gastric Cancer Stem Cells

Hasegawa

Yashiro

Hirakawa

2014

Can Cell Microenviron

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Gastric cancer remains one of the leading causes of global cancer mortality worldwide. In recent years, several studies revealed that gastric cancer contain cancer stem cells (CSCs), a unique subpopulation in tumors, which display stem cell properties: the ability to sustain self-renewal and supply cancer cells. CSCs properties are modulated by their microenvironment, called CSC niche. Recent studies revealed that the interactions between CSC and niche play an important role for the progression of gastric cancer. This brief review presents the current development in gastric cancer stem cell study, which will be useful to find novel therapeutic strategies for gastric cancer.

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Absence of CD71 Transferrin Receptor Characterizes Human Gastric Adenosquamous Carcinoma Stem Cells

Abstract: The present study suggests that use of CD71- as a marker for adenosquamous carcinoma may provide a useful model for studying CSCs.

Cited by 53 publications

References 34 publications

Identifying and targeting cancer stem cells in the treatment of gastric cancer

Identifying and targeting cancer stem cells in the treatment of gastric cancer

Gastric cancer stem cells: evidence, potential markers, and clinical implications

The Role of Cancer-associated Fibroblasts in the Stemness of Gastric Cancer Stem Cells

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