Absence of association of FCGR2A gene polymorphism rs1801274 with Kawasaki disease in Greek patients

Abstract

Kawasaki disease is an acute, febrile syndrome in infancy, characterised by vasculitis of medium-sized arteries, and affects predominantly young children. Family-based studies on Kawasaki disease supports the contribution of genetic factors in disorder manifestation. In a recent genome-wide association study, the polymorphism rs1801274 of FCGR2A [Fc fragment of immunoglobulin G, low-affinity IIa, receptor] gene has been implicated in disease pathogenesis. The aim of the present study was to explore the association of this variant, for the first time, in a group of Kawasaki-diseased patients of Greek origin. A total of 47 Kawasaki-diseased children and 50 control subjects were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism assay was performed in rs1801274 genotyping. No association was observed between this polymorphism genotypes' or alleles' distribution between Kawasaki-diseased patients and controls. Furthermore, no association was revealed between this polymorphism and cardiovascular complications in Kawasaki-diseased patients. In the literature, the reported data over this polymorphism association with Kawasaki disease in Caucasian patients are contradictory. In addition, the disease shows low prevalence in the Caucasian populations. Therefore, the independent genetic association studies on rs1801274 with Kawasaki disease in various Caucasian groups increase the amount of genetic data, which could be used in a future meta-analysis, increasing the statistical power of the resultant conclusions.

Adjuvant herbal therapy for targeting susceptibility genes to Kawasaki disease: An overview of epidemiology, pathogenesis, diagnosis and pharmacological treatment of Kawasaki disease

“…Of note, SNPs (rs4810485 and rs1535045) within CD40 gene were associated with the development of KD in Taiwanese children (Kuo et al, 2012). Although literature has reported the possible genetic role of FCGR2A alleles for the pathophysiology of KD in Chinese children , other studies reported that there is no correlation between the SNP (rs1801274) of FCGRA2 gene and the incident of KD in patients of Greeks origin (Chatzikyriakidou et al, 2015;Qian et al, 2013). In Japan, while the number of CC chemokine ligand 3-like 1 gene copies is highly associated with the occurrence of KD and IVIG resistance, there were no correlation to the pathogenesis of KD in Korean patients (Kim et al, 2012a), suggesting the susceptibility genes for KD may be specific to ethnicity according to the results of GWAS.…”

Use of corticosteroids during acute phase of Kawasaki disease

“…Although the efforts to find a causative microorganism have failed [2][3][4] , the suspicion of an association between some unidentified microorganism and Kawasaki disease remains [4][5][6][7] . Investigations to identify a genetic susceptibility locus in Kawasaki disease also have been performed recently [8][9][10] . Several institutes had cooperated and reported a result regarding the genetic susceptibility of Kawasaki disease [11] .…”

CD32a polymorphism rs1801274 affects the risk of Kawasaki disease

“…During the fulltext screening, 14 more publications were further omitted for not conforming to our inclusion criteria. As a result, 11 eligible reports were ultimately encompassed into this meta- analysis [19][20][21][22][23][24][25][26][27][28][29], containing 17 independent studies. Of the studies, 13 were on Asian populations while only 4 on Caucasians.…”