Absence of association between gallstone and coronary artery calcification

Kwon, Chang Hee; Kang, Jung Gyu; Lee, Hyun Jong; Kim, Nan Hee; Sung, Joo-Wook; Cheong, EunSun; Sung, Ki‐Chul

doi:10.1016/j.atherosclerosis.2017.01.035

Cited by 5 publications

(6 citation statements)

References 29 publications

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“…The association between gallstone and coronary heart disease is still unsettled, as the association was either positive [ 49 ] or null. [ 50 ] Our MR study tended to support the null association between them. However, like NAFLD, we cannot completely rule out their causal relationship, as dyslipidemia plays an important role in cholelithiasis and coronary heart disease.…”

Section: Discussionmentioning

confidence: 66%

Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study

et al. 2021

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Background and Aims:The risk factors of cholelithiasis have not been clearly identified, especially for total cholesterol. Here, we try to identify these causal risk factors. Approach and Results:We obtained genetic variants associated with the exposures at the genome-wide significance (p < 5 × 10 −8 ) level from corresponding genome-wide association studies. Summary-level statistical data for cholelithiasis were obtained from FinnGen and UK Biobank (UKB) consortia. Both univariable and multivariable Mendelian randomization (MR) analyses were conducted to identify causal risk factors of cholelithiasis. Results from FinnGen and UKB were combined using the fixed-effect model. In FinnGen, the odds of cholelithiasis increased per 1-SD increase of body mass index (BMI) (OR = 1.631, p = 2.16 × 10 −7 ), together with body fat percentage (OR = 2.108, p = 4.56 × 10 −3 ) and fasting insulin (OR = 2.340, p = 9.09 × 10 −3 ). The odds of cholelithiasis would also increase with lowering of total cholesterol (OR = 0.789, p = 8.34 × 10 −5 ) and low-density lipoproteincholesterol (LDL-C) (OR = 0.792, p = 2.45 × 10 −4 ). However, LDL-C was not significant in multivariable MR. In UKB, the results of BMI, body fat percentage, total cholesterol, and LDL-C were replicated. In meta-analysis, the liability to type 2 diabetes mellitus and smoking could also increase the risk of cholelithiasis. Moreover, there were no associations with other predominant risk factors.Conclusions: Our MR study corroborated the risk factors of cholelithiasis from previous MR studies. Furthermore, lower total cholesterol level could be an independent risk factor.

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Section: Discussionmentioning

confidence: 66%

Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study

et al. 2021

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“…Previous studies have reached conflicting conclusions about the association between GD and CVD. Several reports have indicated that GD is associated with CVD (8,9), but others have concluded otherwise (7). The conflicting findings may be due to differences in the mean age, sex, geographical region, sample size, study design, follow-up and outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Certain lipid metabolizing genes have been identified as susceptibility genes for GD and CVD in genome-wide association studies or meta-analyses (5,6). Recently, numerous cohort studies have reported an association between GD and CVD (7–9), while others have revealed no association (7). Therefore, a meta-analysis was performed in the present study to better explore the possible associations between CVD and GD.…”

Section: Introductionmentioning

confidence: 99%

Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis

Zhao

Wang

et al. 2019

Exp Ther Med

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Increasing evidence connects gallstone disease (GD) to cardio-cerebrovascular disease (CVD). The aim of the present systematic review and meta-analysis was to determine whether and to what extent an association between GD and CVD existed. PubMed, EMBASE and the Cochrane Library were systemically searched up to March 3rd, 2018. A total of 10 studies (1,272,177 participants; 13,833 records; 5 prospective cohorts and 5 retrospective cohorts) were included. It was demonstrated that GD was associated with an increased risk of incidence [hazard ratio=1.24, 95% (CI) confidence interval: 1.17–1.31] and prevalence (unadjusted odds ratio=1.23, 95% CI: 1.21–1.25) of CVD. In conclusion, the presence of GD was associated with an increased risk of CVD incidence and prevalence. The association may be influenced by age and sex. These findings suggest that individuals identified with cardio-cerebrovascular disease should be evaluated for GD.

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“…Except for the above-mentioned differences in the recording of GsD, the measured outcome was significant CAD, which means stenosis of the lumen of any major artery disease equal to or over 75%. The age of the population studied was 35-65 years, a middle-aged population, in contrast with previous studies on either young East-Asians [38], or older populations [6]. Finally, environmental factors and the Mediterranean diet could have played a huge role in the outcome of our study [53][54][55][56].…”

Section: Resultsmentioning

confidence: 77%

“…Several cross-sectional, cohort and prospective studies have reported a significant association between GsD and ischemic heart disease [6][7][8][9], GsD and carotid atherosclerosis [10,35], GsD and cardiovascular morbidity and mortality [11,13,14], and also GsD and stroke [12]. Other studies however showed no relationship between GsD and CVD [36][37][38], or the relationship was not consistent [39,40].…”

Section: Resultsmentioning

confidence: 99%

Lack of Association between Cholelithiasis and Significant Coronary Artery Disease: An Autopsy Study from Greece

Soutis¹,

Spiliopoulou

Goutas

et al. 2022

JAMMR

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Aims: Cholelithiasis or Gallstone disease and coronary artery disease have been reported to share several common risk factors. The aim of this study was to examine if there is an association between coronary artery disease (CAD) and gallstone disease (GsD) through an autopsy study. Methodology: A retrospective analysis of the records of consecutive autopsy cases performed at the Department of Forensic Medicine and Toxicology of the National and Kapodistrian University of Athens during the period from January 1, 2011, to December 31, 2015, was performed. The inclusion criteria were age between 35 and 65 years old. Our sample consisted of 1699 cases. Significant CAD was defined as stenosis of the lumen equal to or over 75% in any major coronary artery. Results: Significant CAD was found in 656 (38.6%) cases. Results showed that age, male sex, hypertension, smoking (P <0.001), presence of diabetes mellitus (DM)(P =0.005), hyperlipidemia (P =0.001), and illicit drug use (P =0.006) were statistically significant predictors of significant CAD presence. On the contrary, heavy alcohol use (P =0.069), GsD (P =0.838) and cholecystectomy (P =0.423) was not found to be related to significant CAD. Conclusion: Our study did not show any statistically significant relationship between the presence of significant coronary artery stenosis and GsD. The same outcome was noticed when cholecystectomy was studied separately. Therefore, cholelithiasis and cholecystectomy cannot serve as possible predictors for CAD development. Future studies are needed to validate our findings that will lead to more beneficial prevention planning and monitoring of patients so as to maximize resources management and reduce healthcare costs.

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Absence of association between gallstone and coronary artery calcification

Cited by 5 publications

References 29 publications

Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study

Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study

Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis

Lack of Association between Cholelithiasis and Significant Coronary Artery Disease: An Autopsy Study from Greece

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