Absence of Anaphylactic Reactions to Injection of Hemoglobin Vesicles (Artificial Red Cells) to Rodents
Hiromi Sakai,
Tomoko Kure,
Naoko Kobayashi
et al.
Abstract:The safety and efficacy
of hemoglobin vesicles (HbVs) as artificial
oxygen carriers encapsulating a purified and concentrated Hb solution
in liposomes have been studied extensively. The HbV surface, modified
with PEG by incorporating a PEG-conjugated phospholipid, is beneficial
for storage and biocompatibility. However, it might be possible that
interaction of PEG and the pre-existing anti-PEG antibody in the bloodstream
causes acute adverse reaction. This study used two sets of experiments
with rats and guine… Show more
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