Absence of an effect of T89 on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers

Wang, Ping; Sun, He; Liu, Yang; Li, Lingyan; Hao, Jing; Ruff, Dennis; Guo, Zhi‐Xin

doi:10.1002/jcph.209

Cited by 10 publications

(7 citation statements)

References 19 publications

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“…After warfarin, which was metabolized primarily by CYP2C9, CYP1A2, and CYP2C19 [71], reached steady-state in healthy volunteers, T89 was added in combination with warfarin for another week. T89 had no significant effect on total concentration and pharmacodynamic effect of warfarin [68]. This nonsignificant change in warfarin pharmacokinetics is consistent with the in vitro finding that hydrophilic phenolic acids exhibited high IC50 values against CYP450 activities (Table 1), which cannot be reached after regular dose of Danshen.…”

Section: Pharmacokinetic Interaction Caused By Salvia Miltiorrhizasupporting

confidence: 80%

Salvia miltiorrhizaRoots against Cardiovascular Disease: Consideration of Herb-Drug Interactions

Chen¹,

Tian

2017

BioMed Research International

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Salvia miltiorrhiza root (Danshen) is widely used in Asia for its cardiovascular benefits and contains both hydrophilic phenolic acids and lipophilic tanshinones, which are believed to be responsible for its therapeutic efficacy. This review summarized the effects of these bioactive components from S. miltiorrhiza roots on pharmacokinetics of comedicated drugs with mechanic insights regarding alterations of protein binding, enzyme activity, and transporter activity based on the published data stemming from both in vitro and in vivo human studies. In vitro studies indicated that cytochrome P450 (CYP450), carboxylesterase enzyme, catechol-O-methyltransferase, organic anion transporter 1 (OAT1) and OAT3, and P-glycoprotein were the major targets involved in S. miltiorrhiza-drug interactions. Lipophilic tanshinones had much more potent inhibitory effects towards CYPs activities compared to hydrophilic phenolic acids, evidenced by much lower Ki values of the former. Clinical S. miltiorrhiza-drug interaction studies were mainly conducted using CYP1A2 and CYP3A4 probe substrates. In addition, the effects of coexisting components on the pharmacokinetic behaviors of those noted bioactive compounds were also included herein.

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Section: Pharmacokinetic Interaction Caused By Salvia Miltiorrhizasupporting

confidence: 80%

Salvia miltiorrhizaRoots against Cardiovascular Disease: Consideration of Herb-Drug Interactions

Chen¹,

Tian

2017

BioMed Research International

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“…Dantonic pill (also known as the Compound Danshen Dripping Pill), consisting of Salviae miltiorrhize (SM), Panax notoginseng (PN) and Borneol , has been widely used as a compound Chinese medicine for preventing and treating ischemic cardiovascular diseases in China for past 30 years (Wang et al, ). It has been approved to enter phase III clinical trials by the US Food and Drug Administration.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of tanshinol, protocatechuic aldehyde, protocatechuic acid, notoginsenoside R1, ginsenoside Rg1 and Rb1 in rat plasma by LC–MS/MS and its application

Yang

et al. 2017

Biomedical Chromatography

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Dantonic pill, consisting of Salviae miltiorrhize, Panax notoginseng and Borneol, is a widely used compound Chinese medicine for preventing and treating ischemic cardiovascular diseases in China. In the present study, an original and sensitive method for simultaneous determination of tanshinol (i.e. danshensu), protocatechuic aldehyde, protocatechuic acid, notoginsenoside R1, ginsenoside Rg1 and Rb1 in rat plasma by liquid chromatography-tandem mass spectrometry operated in positive/negative ion switching mode was established and validated. The lower limits of quantification for tanshinol, protocatechuic aldehyde, protocatechuic acid, notoginsenoside R1, ginsenoside Rg1 and Rb1 were 5, 0.5, 1, 0.5, 0.5 and 2 ng/mL, respectively. All of the calibration curves showed good linearity over the investigated concentration range (r> 0.99). Validation results demonstrated that the above compounds were accurately, precisely and robustly quantified in rat plasma. The method was successfully applied to characterize the pharmacokinetic profiles of all six compounds in rats following a single oral administration of Dantonic pill.

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“…Radix Salvia miltiorrhiza (Danshen) is one of the typical blood-activating and stasis-resolving medicines and it offers therapeutic promise for cardiovascular diseases ( Wang et al, 2014 ). Salvianolic acids are the maximum water extraction from Danshen including salvianolic acid A (Sal A) and salvianolic acid B (Sal B).…”

Section: Chinese Herbal Medicines Targeting Angiogenesis In Ischemic mentioning

confidence: 99%

Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review

et al. 2018

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Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting patients that are unable to undergo angioplasty or bypass surgery. Chinese herbal medicines have been used for more than 2,500 years and they play an important role alongside contemporary medicines in China. Growing evidence in animal models show Chinese herbal medicines can provide therapeutic effect on IHD by targeting angiogenesis. Identifying the mechanism in which Chinese herbal medicines can promote angiogenesis in IHD is a major topic in the field of traditional Chinese medicine, and has the potential for advancing therapeutic treatment. This review summarizes the progression of research and highlights potential pro-angiogenic mechanisms of Chinese herbal medicines in IHD. In addition, an outline of the limitations of Chinese herbal medicines and challenges they face will be presented.

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Absence of an effect of T89 on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers

Cited by 10 publications

References 19 publications

Salvia miltiorrhizaRoots against Cardiovascular Disease: Consideration of Herb-Drug Interactions

Salvia miltiorrhizaRoots against Cardiovascular Disease: Consideration of Herb-Drug Interactions

Simultaneous determination of tanshinol, protocatechuic aldehyde, protocatechuic acid, notoginsenoside R1, ginsenoside Rg1 and Rb1 in rat plasma by LC–MS/MS and its application

Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review

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