Abscisic acid and abiotic stress tolerance – Different tiers of regulation

Mehrotra, Rajesh; Bhalothia, Purva; Bansal, Prashali; Basantani, Mahesh Kumar; Bharti, Vandana; Mehrotra, Santosh

doi:10.1016/j.jplph.2013.12.007

Cited by 167 publications

(93 citation statements)

References 119 publications

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“…Drought, a drastic condition for plants and signaled through a pathway involving abscisic acid, is linked to chromatin changes [reviewed in [37][38][39]. Often connected with dehydration is osmotic stress or salinity, also elucidating responses at the chromatin level [reviewed in 40].…”

Section: Stress Types Modifying Chromatin Parametersmentioning

confidence: 99%

Stress-induced structural changes in plant chromatin

Probst

Scheid

2015

Current Opinion in Plant Biology

148

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Stress defense in plants is elaborated at the level of protection and adaptation. Dynamic changes in sophisticated chromatin substructures and concomitant transcriptional changes play an important role in response to stress, as illustrated by the transient rearrangement of compact heterochromatin structures or the modulation of chromatin composition and modification upon stress exposure. To connect cytological, developmental, and molecular data around stress and chromatin is currently an interesting, multifaceted, and sometimes controversial field of research. This review highlights some of the most recent findings on nuclear reorganization, histone variants, histone chaperones, DNA- and histone modifications, and somatic and meiotic heritability in connection with stress.

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Section: Stress Types Modifying Chromatin Parametersmentioning

confidence: 99%

Stress-induced structural changes in plant chromatin

Probst

Scheid

2015

Current Opinion in Plant Biology

148

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“…Full understanding of the mechanisms ensuring plant adaptation to stress can assist in obtaining tolerant varieties. ABA, which is the major stress phytohormone, takes part in a plant’s adaptation to stress through regulation of physiological processes such as the biosynthesis of osmolytes and the detoxification of ROS (Reactive Oxygen Species); (reviewed by Roychoudhury et al, 2013; Mehrotra et al, 2014; Yoshida et al, 2014; Munemasa et al, 2015; Jones, 2016; Sah et al, 2016). Generally, ABA is considered to be a shoot and root growth inhibitor that acts to save water and energy under stress.…”

Section: Introductionmentioning

confidence: 99%

The Role and Regulation of ABI5 (ABA-Insensitive 5) in Plant Development, Abiotic Stress Responses and Phytohormone Crosstalk

2016

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ABA Insensitive 5 (ABI5) is a basic leucine zipper transcription factor that plays a key role in the regulation of seed germination and early seedling growth in the presence of ABA and abiotic stresses. ABI5 functions in the core ABA signaling, which is composed of PYR/PYL/RCAR receptors, PP2C phosphatases and SnRK2 kinases, through the regulation of the expression of genes that contain the ABSCISIC ACID RESPONSE ELEMENT (ABRE) motif within their promoter region. The regulated targets include stress adaptation genes, e.g., LEA proteins. However, the expression and activation of ABI5 is not only dependent on the core ABA signaling. Many transcription factors such as ABI3, ABI4, MYB7 and WRKYs play either a positive or a negative role in the regulation of ABI5 expression. Additionally, the stability and activity of ABI5 are also regulated by other proteins through post-translational modifications such as phosphorylation, ubiquitination, sumoylation and S-nitrosylation. Moreover, ABI5 also acts as an ABA and other phytohormone signaling integrator. Components of auxin, cytokinin, gibberellic acid, jasmonate and brassinosteroid signaling and metabolism pathways were shown to take part in ABI5 regulation and/or to be regulated by ABI5. Monocot orthologs of AtABI5 have been identified. Although their roles in the molecular and physiological adaptations during abiotic stress have been elucidated, knowledge about their detailed action still remains elusive. Here, we describe the recent advances in understanding the action of ABI5 in early developmental processes and the adaptation of plants to unfavorable environmental conditions. We also focus on ABI5 relation to other phytohormones in the abiotic stress response of plants.

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“…[2][3][4] In these organisms, ABA functions in immune and metabolic processes, including desiccation tolerance in plants, heat stress response in sponges, and insulin release in humans. [5][6][7] ABA also increases cell proliferation, regulating regeneration in hydroids and expansion of human mesenchymal stem cells. 8,9 This conservation across eukaryotes led us to hypothesize that ABA might function in the interactions among mammals, mosquitoes, and Plasmodium to alter dynamics of malaria parasite infection and transmission.…”

Section: Introductionmentioning

confidence: 99%

Supplementation with Abscisic Acid Reduces Malaria Disease Severity and Parasite Transmission

Glennon¹,

Adams²,

Hicks³

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. Nearly half of the world's population is at risk for malaria. Increasing drug resistance has intensified the need for novel therapeutics, including treatments with intrinsic transmission-blocking properties. In this study, we demonstrate that the isoprenoid abscisic acid (ABA) modulates signaling in the mammalian host to reduce parasitemia and the formation of transmissible gametocytes and in the mosquito host to reduce parasite infection. Oral ABA supplementation in a mouse model of malaria was well tolerated and led to reduced pathology and enhanced gene expression in the liver and spleen consistent with infection recovery. Oral ABA supplementation also increased mouse plasma ABA to levels that can signal in the mosquito midgut upon blood ingestion. Accordingly, we showed that supplementation of a Plasmodium falciparum-infected blood meal with ABA increased expression of mosquito nitric oxide synthase and reduced infection prevalence in a nitric oxide-dependent manner. Identification of the mechanisms whereby ABA reduces parasite growth in mammals and mosquitoes could shed light on the balance of immunity and metabolism across eukaryotes and provide a strong foundation for clinical translation.

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Abscisic acid and abiotic stress tolerance – Different tiers of regulation

Cited by 167 publications

References 119 publications

Stress-induced structural changes in plant chromatin

Stress-induced structural changes in plant chromatin

The Role and Regulation of ABI5 (ABA-Insensitive 5) in Plant Development, Abiotic Stress Responses and Phytohormone Crosstalk

Supplementation with Abscisic Acid Reduces Malaria Disease Severity and Parasite Transmission

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