Abscisic Acid: A Versatile Phytohormone in Plant Signaling and Beyond

Gómez-Cádenas, Aurelio; Vives‐Peris, Vicente; Zandalinas, Sara I.; Manzi, Matías; Sánchez-Pérez, Ana; Pérez-Clemente, Rosa M.; Arbona, Vicent

doi:10.2174/1389203716666150330130102

Cited by 80 publications

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“…While ABA repression of ilp3 and ilp4 transcript levels in the A. stephensi midgut was consistent with the effects of ABA on P. falciparum infection, our previous studies of these peptides [13] as well as observed effects of ABA on mammals and plants [33–36] suggested that ABA may have broader effects on A. stephensi physiology. A major target of IIS is phosphorylation and inhibition of GSK-3, a pivotal mediator of metabolism, inflammation, cell death, and survival in mammalian cells [37].…”

Section: Resultssupporting

confidence: 83%

Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity

Glennon

Torrevillas

Morrissey³

et al. 2017

Parasites Vectors

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BackgroundAbscisic acid (ABA) is naturally present in mammalian blood and circulating levels can be increased by oral supplementation. We showed previously that oral ABA supplementation in a mouse model of Plasmodium yoelii 17XNL infection reduced parasitemia and gametocytemia, spleen and liver pathology, and parasite transmission to the mosquito Anopheles stephensi fed on these mice. Treatment of cultured Plasmodium falciparum with ABA at levels detected in our model had no effects on asexual growth or gametocyte formation in vitro. However, ABA treatment of cultured P. falciparum immediately prior to mosquito feeding significantly reduced oocyst development in A. stephensi via ABA-dependent synthesis of nitric oxide (NO) in the mosquito midgut.ResultsHere we describe the mechanisms of effects of ABA on mosquito physiology, which are dependent on phosphorylation of TGF-β-activated kinase 1 (TAK1) and associated with changes in homeostatic gene expression and activity of kinases that are central to metabolic regulation in the midgut epithelium. Collectively, the timing of these effects suggests a transient physiological shift that enhances NF-κB-dependent innate immunity without significantly altering mosquito lifespan or fecundity.ConclusionsABA is a highly conserved regulator of immune and metabolic homeostasis within the malaria vector A. stephensi with potential as a transmission-blocking supplemental treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2276-4) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 83%

Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity

Glennon

Torrevillas

Morrissey³

et al. 2017

Parasites Vectors

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“…ABA is considered the primary hormone involved in regulation of plant responses to abiotic stresses, especially drought32. ABA levels were observed to increase in both roots (all tested plant combinations) and leaves (except for RL) (Fig.…”

Section: Discussionmentioning

confidence: 94%

Survival strategies of citrus rootstocks subjected to drought

Santana-Vieira

Freschi

Almeida

et al. 2016

Sci Rep

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Two citrus rootstocks, Rangpur lime (RL) and Sunki Maravilha mandarin (SM), were analyzed either ungrafted or grafted with their reciprocal graft combinations or with shoot scions of two commercial citrus varieties: Valencia orange (VO) and Tahiti acid lime (TAL). All graft combinations were subjected to distinct watering regimes: well-watered, severe drought and rehydration. Growth and water relation parameters, gas exchange as well as sugar and hormone profiles were determined. Data indicated that RL adopted a dehydration avoidance strategy and maintained growth, whereas SM adopted a dehydration tolerance strategy focused on plant survival. Compared with RL, the leaves and roots of SM exhibited higher concentrations of abscisic acid and salicylic acid, which induced drought tolerance, and accumulation of carbohydrates such as trehalose and raffinose, which are important reactive oxygen species scavengers. SM rootstocks were able to transfer their survival strategy to the grafted shoot scions (RL, VO, TAL). Because of their contrasting survival strategies, RL reached the permanent wilting point more quickly than SM whereas SM recovered from prolonged droughts more efficiently than RL. This is one of the most complete studies of drought tolerance mechanisms in citrus crops and is the first to use reciprocal grafting to clarify scion/rootstock interactions.

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“…Most of the plant responses to these abiotic conditions are mediated by abscisic acid. The ABA-signaling pathway is initiated by its binding to the specific receptor complex RCARs/PYR1/PYLs, leading to inactivation of type 2C protein phosphatases and activation of kinases, which mediate ABA-dependent changes in metabolism, gene expression, and ion channel activity (3, 4). …”

Section: Introductionmentioning

confidence: 99%

Abscisic Acid: A Novel Nutraceutical for Glycemic Control

et al. 2017

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Abscisic acid is naturally present in fruits and vegetables, and it plays an important role in managing glucose homeostasis in humans. According to the latest U.S. dietary survey, about 92% of the population might have a deficient intake of ABA due to their deficient intake of fruits and vegetables. This review summarizes the in vitro, preclinical, mechanistic, and human translational findings obtained over the past 15 years in the study of the role of ABA in glycemic control. In 2007, dietary ABA was first reported to ameliorate glucose tolerance and obesity-related inflammation in mice. The most recent findings regarding the topic of ABA and its proposed receptor lanthionine synthetase C-like 2 in glycemic control and their interplay with insulin and glucagon-like peptide-1 suggest a major role for ABA in the physiological response to a glucose load in humans. Moreover, emerging evidence suggests that the ABA response might be dysfunctional in diabetic subjects. Follow on intervention studies in healthy individuals show that low-dose dietary ABA administration exerts a beneficial effect on the glycemia and insulinemia profiles after oral glucose load. These recent findings showing benefits in humans, together with extensive efficacy data in mouse models of diabetes and inflammatory disease, suggest the need for reference ABA values and its possible exploitation of the glycemia-lowering effects of ABA for preventative purposes. Larger clinical studies on healthy, prediabetic, and diabetic subjects are needed to determine whether addressing the widespread dietary ABA deficiency improves glucose control in humans.

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Abscisic Acid: A Versatile Phytohormone in Plant Signaling and Beyond

Cited by 80 publications

References 0 publications

Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity

Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity

Survival strategies of citrus rootstocks subjected to drought

Abscisic Acid: A Novel Nutraceutical for Glycemic Control

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