Abscesses of the bulbourethral glands of mice due to Pasteurella pneumotropica

Abstract

ABSZESSE DER GLANDULAE BULBOURETHRALES VON MAUSEN DURCH PASTEURELLA PNEUMOTROPlCA ABCES DES GLANDES BULBO-URETHRALES DES SOURIS cAusEs PAR PASTEURELLA PNEUMOTROPlCAC3H/Bi/Icrf and Simpson/Jcrf adult male mice are often submitted for investigation, singly or in small groups, with unilateral or bilateral swellings in the perineal region. These invariably prove to be abscesses containing green creamy pus. Bacteriological examination yields Pasteurella pneumatropica in nearly all cases.Careful dissection of the perineal region reveales that the abscesses involve the bulbourethral glands on one or both sides (Fig. 1). Jn some cases an abscess fully replaces the bulbourethral gland on one side, whilst the gland on the other side is enlarged, showing on histological section evidence of infiltration with polymorphs (Fig. 2), accumulation of purulent material in the dilated ducts, and other inflammatory changes.These may be milder or earlier manifestations of the same process that leads to abscess formation. Jn culture the organism produces non-haemolytic, slightly opaque, yellowish coloured colonies of 1 mm diameter on 5 % blood-agar plates after 24 h aerobic incubation. It is a non-motile, small, gram-negative coccobacillus, with a tendency to form short filaments.It is oxidase-, catalase-, urease-and nidole-positive.It produces acid but no gas in glucose, lactose, sucrose, maltose, and xylose, but it does not acidify mannitol and inositol.

Bulbourethral gland infections in mice associated with Staphylococcus aureus

“…Interestingly, the 1 mouse affected in the small survey of non-experimental animals, examined 38 weeks after issue, yielded Staphylococcus aureus and Pasteurella pneumotropica from a bulbourethral gland abscess. Sebesteny (1973) reported the isolation of the latter organism from bulbourethral gland infections, but made no mention of…”

Epithelial Bmp (Bone morphogenetic protein) signaling for bulbourethral gland development: A mouse model for congenital cystic dilation

“…Bacterial infection, an external injury, chemical and environmental hormone treatment might also cause the inflammation and pathogenesis in several organs, including the urinary tract (Takano et al 2002;Ike et al 2007). It has been indicated that Pasteurella pneumotropica causes abscesses in the BUG (Sebesteny 1973). Inflammatory responses in such cystic lesions have also been reported in other case of mutant mice associated with Bmp signaling genes (Mysorekar et al 2009).…”

“…2007). It has been indicated that Pasteurella pneumotropica causes abscesses in the BUG (Sebesteny 1973). Inflammatory responses in such cystic lesions have also been reported in other case of mutant mice associated with Bmp signaling genes (Mysorekar et al .…”

Clonal outbreaks of [Pasteurella] pneumotropica biovar Heyl in two mouse colonies

“…4,21–23 In addition to the respiratory tract and orbital infections, mastitis, urogenital and subcutaneous infections have also been described. 4,21,24–27…”