Abscesos pulmonares por Prevotella oralis y Prevotella ruminicola en paciente VIH

Sánchez, F. Marcos; Castaño, I. Albo; Linde, F. Árbol; Gil, Jordi

doi:10.4321/s0212-71992003000300017

Cited by 1 publication

(1 citation statement)

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“…The severe immune suppression associated with HIV infection has been shown to affect the gut microbiome profile of the individual, which could lead to other complications of the immune system. The association of HIV and Prevotella infections or high abundance of Prevotella has been shown very often in several studies, especially in patients with a high plasmatic viral load [28–38]. In HIV patients, Hensley-McBain et al [38] reported a reduction in the Lactobacillus: Prevotella ratio associated with the survival of neutrophils, suggesting that gut bacteria may contribute to the buildup of gastrointestinal neutrophils in treated HIV infection.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 and Prevotella spp.: friend or foe? A systematic literature review

Tamanai-Shacoori

Gall‐David

Moussouni

et al. 2022

Journal of Medical Microbiology

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During this global pandemic of the COVID-19 disease, a lot of information has arisen in the media and online without scientific validation, and among these is the possibility that this disease could be aggravated by a secondary bacterial infection such as Prevotella, as well as the interest or not in using azithromycin, a potentially active antimicrobial agent. The aim of this study was to carry out a systematic literature review, to prove or disprove these allegations by scientific arguments. The search included Medline, PubMed, and Pubtator Central databases for English-language articles published 1999–2021. After removing duplicates, a total of final eligible studies (n=149) were selected. There were more articles showing an increase of Prevotella abundance in the presence of viral infection like that related to Human Immunodeficiency Virus (HIV), Papillomavirus (HPV), Herpesviridae and respiratory virus, highlighting differences according to methodologies and patient groups. The arguments for or against the use of azithromycin are stated in light of the results of the literature, showing the role of intercurrent factors, such as age, drug consumption, the presence of cancer or periodontal diseases. However, clinical trials are lacking to prove the direct link between the presence of Prevotella spp. and a worsening of COVID-19, mainly those using azithromycin alone in this indication.

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