Abruptio placentae

Valera, Eamonn de

doi:10.1016/s0002-9378(15)33385-8

Cited by 16 publications

(5 citation statements)

References 2 publications

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“…It is also important that the vasoconstriction in the uterine arteries further increases uterine contraction. 19 Local cold stress to the soles at 0°C induced uterine contraction significantly in our study. Norepinephrine is a potent agonist in contracting the uterus of various species.…”

Section: Discussionsupporting

confidence: 50%

“…Severe abruptio placentae is associated with profound hypovolemia with intense vasoconstriction. 19 This vasoconstriction not only maintains a deceptively high arterial pressure but also leads to impaired tissue perfusion in most parts of the body. It is also important that the vasoconstriction in the uterine arteries further increases uterine contraction.…”

Section: Discussionmentioning

confidence: 99%

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Local Cold Stress to the Soles Induces Retroplacental Hemorrhage in Rats

Khatun¹,

Kobayashi²,

Belayet³

et al. 2001

Semin Thromb Hemost

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The aim of this study was to investigate the effect of local cold stress to the soles on placental histology in rats. Pregnant rats were subjected to a cold provocation (0 degrees C, 12 degrees C) and room temperature (23 degrees C) for 15 and 30 minutes. During cold stimulation and at the control temperature, uterine blood flow and uterine contraction were measured simultaneously. Histological studies of the placentas of these rats were also performed. Cold stress at 0 degrees C and 12 degrees C significantly decreased uterine blood flow (P < .005, P < .02) compared with controls (23 degrees C). The decrease in uterine blood flow was greater at 0 degrees C than at 12 degrees C stress. Cold-induced stress (0 degrees C) also evoked an isometric tension with increased frequency and amplitude in the rat uterus (P < .003, P < .0002) compared with controls (23 degrees C). Stimulation at 12 degrees C did not induce any uterine contractions. Placental histology of rats stressed at 0 degreesC revealed hemorrhages into the decidua basalis. These findings suggest that local cold stress decreases uterine blood flow and increases uterine contraction, resulting in retroplacental hemorrhage in rats. This model may account for human abruptio placentae.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Local Cold Stress to the Soles Induces Retroplacental Hemorrhage in Rats

Khatun¹,

Kobayashi²,

Belayet³

et al. 2001

Semin Thromb Hemost

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show abstract

“…Despite the lack of clarity surrounding the association between multiparity and maternal well‐being, some consensus is present among researchers that placenta previa (13,15,16,37,38,42,45), abruptio placentae (13,37,42,45,47,48), abnormal presentations (2,5,8,16,25,42), hemorrhagic complications (2), and ruptured uterus (15,42,49) occur more commonly in grand multiparas when compared with multiparas and primiparas.…”

Section: Resultsmentioning

confidence: 99%

High Parity and Adverse Birth Outcomes: Exploring the Maze

Aliyu

Jolly

Ehiri

et al. 2005

Birth

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“…Similarly, in young grand multiparas the cumulative effects of many deliveries may prematurely age the uterus and increase the subsequent risk of developing previa. Hypertension, long hypothesized to play a causal role in placental abruption in grand multiparas, likely contributes to the etiology of this condition in these women (24). Nutritional deficiencies may also play a role in the pathophysiology of abruption in this population (25,26).…”

Section: Discussionmentioning

confidence: 99%