Abrupt onset of diabetes during interferon‐alpha therapy in patients with chronic hepatitis C

Abstract

Type 1 diabetes should be considered as a potential complication if IFN is administered to patients with chronic hepatitis C. Its onset may be severe and result in short-term difficulties in metabolic control.

Trajectories of anti-islet autoantibodies before development of type 1 diabetes in interferon-treated hepatitis C patients. Case reports and a literature review

“…He had no family history of diabe-body negative even after the onset of type 1 diabetes, although data for some autoantibodies such as ZnT8Ab were not available. These results suggest that GADAb may be a good predictive and diagnostic marker for IFN-induced type 1 diabetes, as has been reported in sporadic cases [2][3][4][5][6][7][8][9][10][11][12]. This needs to be verified in the future study using a large number of subjects.…”

Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C

“…Diabetic ketoacidosis was reported in a few classical IFN-α related cases [23][24][25][26] , in one pegylated IFN-α related case [21] and the case herein described. The development of diabetic ketoacidosis and the permanent insulin dependency thereafter indicated a severe metabolic disturbance, which may be attributed to a rapidly developing Th1-mediated pathogenic reaction [23] .…”

Late Development of Diabetes mellitus after Interferon-Alfa and Ribavirin Therapy for Chronic Hepatitis C: A Case Report

“…HCV infection has been linked to an increased prevalence of non-insulin-dependent diabetes mellitus (type-2 diabetes mellitus) in a number of reports [6,7] . While the liver is important for glucose homeostasis and diabetes may occur more often in patients with HCV infection because of hepatocyte dysfunction and insulin resistance, it is also possible that autoimmune phenomena related to HCV may induce diabetes mellitus as reported in cases of autoimmune diseases such as Hashimoto's thyroiditis, glomerulonephritis, Sjögren's disease and cryoglobulinemia [8] .…”