“…Given the critical importance of vascular disease in affecting the nervous system, SIRT1 and its ability to oversee small non-coding ribonucleic acids (RNAs), termed microRNAs (miRNAs) (134, 158–160), have become exciting targets for vascular disease and the nervous system (Figure 1). SIRT1 pathways are involved in vascular survival and senescence (88, 152, 161), atherosclerosis (162–166), lifespan extension (4, 167–169), diabetic retinopathy (170), cellular metabolism and DM (14, 17, 20, 115, 145, 171, 172), oxidative stress pathways (58, 148, 173–179), and neuronal survival and cognition (11, 113, 180–183).…”