Abrogated Thymoma Development and Increased Amyloid Development in Estrogenized Mice Grafted Spleen and Bone Marrow Cells

Ebbesen, Peter; Doenhoff, Michael J.

doi:10.3181/00379727-138-36004

Cited by 10 publications

(4 citation statements)

References 6 publications

(8 reference statements)

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“…Repeated grafting of lymphoid cells, as done in the present and previous experiments (Ebbesen and Doenhoff, 1971;Metcalf, 1962) or grafting of whole thymus (Gershwin et al, 1976) from young syngeneic donors to intact recipients, does not influence development of leukaemia or time of death in AKR or other mice (Albright and Makinodan, 1966). Grafting of thymus from old AKR donors to young syngeneic recipients, however, does cause early death (Gershwin et al, 1976).…”

Section: Discussionsupporting

confidence: 50%

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Life span, leukaemia and amyloid incidences of untreated and polycation-treated AKR mice

Ebbesen¹

1978

Br J Cancer

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Summary.-AKR mice, which have a short mean survival time and usually die with leukaemia, were studied from one month of age for correlation between these two parameters. For untreated animals we found the same mean survival time whether or not leukaemia occurred. By treating sucklings with the polycations diethylaminoethyl-dextran or hexadimethrine bromide the leukaemia incidence was significantly reduced. However, the mean survival time was unchanged, and remained the same in leukaemic and non-leukaemic animals. It is therefore suggested that the early death of AKR mice results from an ageing process and does not require leukaemia for implementation. Our prophylactic polycation treatment was furthermore found to induce spleen amyloid in some but not all of the mice that remained non-leukaemic.

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Section: Discussionsupporting

confidence: 50%

“…The graft-vs-host and skin-allograft-rejection experiments showed no effect on these Tcell functions. Amyloid and leukaemia occurred again (Ebbesen and Doenhoff, 1971;Ebbesen, 1974a) …”

Section: Discussionmentioning

confidence: 99%

Life span, leukaemia and amyloid incidences of untreated and polycation-treated AKR mice

Ebbesen¹

1978

Br J Cancer

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“…Haematocrit values and electrophoresis on cellulose acetate were found normal in all groups of BALB/c mice. None of the 51 saline treated mice, but 7 out of 45 oestrogen treated, non-thymectomized mice developed thymic lymphoma with heavy infiltration of the enlarged thymuses and peripheral leucocyte counts of between lo4 and los cells per mrn3 (13). Cysts were seen in some leukaemic thymuses.…”

Section: R E S U L T Smentioning

confidence: 95%

THYMIC CYSTS IN OESTROGENIZED BALB/c MICE

Ebbesen

Nielsen

1972

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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BALB/c male mice injected monthly with 1 mg oestradiol benzoas developed testicular tumours, a generalized lymphocyte depletion, clusters of PAS positive cells in spleen and lymph nodes, spleen amyloid and PAS positive thymus cysts. Treatment of castrated males and intact females induced the same thymus cysts. Thymectomy at three days of age aggravated the lymphopenia, reduced the survival time and accelerated spleen amyloid development in oestrogen treated male and female mice. Testicular tumours appeared in some thymectomized males. All thymus cysts contained gamma globulin and albumin. A lymphocytestimulating factor was not found in thymus extracts of treated mice and Coombs' test and indirect fluorescence tests for autoantibodies were negative. Electron microscopic findings were consistent with ongoing transport by pinocytosis through the cells lining the thymus cysts.

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“…IN PREVIOUS studies on oestrogen induced thymic leukaemias in BALB/c male and female mice we have found either amyloidosis or leukaemia but never both lesions simultaneously in the same animal (Ebbesen and Doenhoff, 1971). To investigate whether development of amyloidosis and thymic leukaemia is causally interrelated we have induced amyloidosis in mice of the AKR strain which has a very high incidence of spontaneous thymic leukaemias.…”

mentioning

confidence: 99%

Mutually exclusive occurrence of amyloidosis and thymic leukaemia in casein treated AKR mice

Ebbesen¹

1974

Br J Cancer

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Abrogated Thymoma Development and Increased Amyloid Development in Estrogenized Mice Grafted Spleen and Bone Marrow Cells

Cited by 10 publications

References 6 publications

Life span, leukaemia and amyloid incidences of untreated and polycation-treated AKR mice

Life span, leukaemia and amyloid incidences of untreated and polycation-treated AKR mice

THYMIC CYSTS IN OESTROGENIZED BALB/c MICE

Mutually exclusive occurrence of amyloidosis and thymic leukaemia in casein treated AKR mice

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