Abrikossoff's Tumor

Abstract

Abrikossoff's tumor is a disease that more commonly affects the oral cavity but can also occur at other sites. It develops between the second and sixth decades of life, more frequently among women and blacks. The neoplasm can affect all parts of the body. The head and neck areas are affected in 45% to 65% of cases and of these, 70% are located interorally (tongue, oral mucosa, hard palate). The benign form shows polygonal cells with granular, eosinophilic cytoplasm and small nuclei. The malignant form, however, is associated with a high mitotic index and pleomorphic cellular tissue. The clinical aspect of the neoformation is a swelling covered by mucus of normal appearance. Studies of the neoformation show that in addition to the objective examination, further instrumental research is necessary, i.e., with nuclear magnetic resonance or computed tomography with contrast CT scan. However, the only examination that can confirm the clinical diagnosis is the histological examination. The only treatment for Abrikossoff tumor is surgery. The surgical treatment provides for an extirpation of the neoformation with the overhanging mucus and the underlying periosteum. In this work, the authors discuss a case of Abrikossoff tumor affecting the mucus of the right side of the hemipalate in a 53-year-old patient and present a review of the literature.

A Case of Mediastinal Granular Cell Tumor with Horner’s Syndrome

“…4,5) Although, there is a considerable difference between GCTs and schwannoma at the ultrastructural level, they are common benign tumors of Schwann cell origin that contain numerous granules in their cytoplasm. A recent study by Shintaku 6) revealed that this morphological difference merely reflects the accelerated formation of autophagosomes in GCTs.…”

Histochemistry and Immunohistochemistry Evaluation of the Abrikossoff’s Tumour of the Tongue: a Case Report

“…In particular, we must always make a differential diagnosis, as in our case where the diagnosis of Abrikossoff's tumour was not certain. Features such as consistency, colour and the possible definition of lesion margins upon palpation may facilitate the establishment of diagnostic hypotheses (5,9).…”

“…Svakom se slučaju uvijek mora pristupiti diferencijalno dijagnostički jer kod naše pacijentice nismo bili sigurni je li riječ o Abrikossoffovu tumoru. Svojstva poput konzistencije i boje te palpacija rubova lezije mogu olakšati postavljanje dijagnostičke hipoteze (5,9).…”

“…Most GCTs occur in the head and neck region, especially in the tongue, cheek mucosa, and palate (5).…”

Tumeur à cellules granuleuses de la langue : présentation d’un cas et revue de la littérature

“…La TCG est le plus souvent unique mais on retrouve des formes multifocales dans 5 à 25 % des cas et elles sont surtout observées chez la race noire [4]. Elles apparaissent simultané-ment ou successivement avec un délai variant de 4 à 6 ans [6].…”