ABR findings in musicians with normal audiogram and otoacoustic emissions: evidence of cochlear synaptopathy?

Kikidis, Dimitrios; Vardonikolaki, Aikaterini; Zachou, Zoe; Razou, Andriana; Pantos, Pavlos; Bibas, Athanasios

doi:10.1080/21695717.2019.1663054

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…However, a reduction of ABR wave I amplitude associated with noise exposure has been found by some researchers in non-occupational samples of persons exposed to noise (Stamper and Johnson, 2015;Valderrama et al, 2018;Wang et al, 2021). In addition, a reduction in wave I amplitude was observed in a population of veterans exposed to firearms (Bramhall et al, 2017) and in a population of musicians (Kikidis et al, 2020). A number of factors, such as participants' inclusion criteria, noise exposure metrics, and participants' profiles, may explain the differences in study results.…”

Section: Auditory Brainstem Response Outcomesmentioning

confidence: 73%

“…Finally, the stimulation rate may be another explanation for the divergent results among studies. Kikidis et al (2020) found a reduced ABR wave I amplitude and I/V amplitude ratio in musicians compared to non-musicians, and such differences were more marked at higher stimulation rates. The authors concluded that a higher stimulation rate would better allow the detection of cochlear synaptopathy.…”

Section: Auditory Brainstem Response Outcomesmentioning

confidence: 79%

“…A number of factors, such as participants' inclusion criteria, noise exposure metrics, and participants' profiles, may explain the differences in study results. In two of these studies (Valderrama et al, 2018;Kikidis et al, 2020), researchers did not control for possible hair cell deficits (measured by hearing thresholds and DPOAEs), which could likely explain the reduced ABR wave I amplitude in the noise-exposed group.…”

Section: Auditory Brainstem Response Outcomesmentioning

confidence: 99%

“…Results from different studies using these procedures with normal hearing young individuals are controversial. This is because some studies have found an association between ABR measures and/or SPiN test results and noise exposure (e.g., Liberman et al, 2016;Bramhall et al, 2017;Grant et al, 2020;Kikidis et al, 2020;Wang et al, 2021), while others have not (e.g., Fulbright et al, 2017;Grinn et al, 2017;Grose et al, 2017;Prendergast et al, 2017a,b;Yeend et al, 2017;Washnik et al, 2020). Some authors have suggested that ABR and SPiN measures may not be sensitive enough to detect this condition or that cochlear synaptopathy may not manifest in young people with normal hearing thresholds (Guest et al, 2018;Bramhall, 2021).…”

Section: Introductionmentioning

confidence: 99%

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No effect of occupational noise exposure on auditory brainstem response and speech perception in noise

Pinsonnault-Skvarenina

Moïn-Darbari

Zhao

et al. 2022

Front. Neurosci.

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The primary aim of this study was to investigate whether auditory brainstem response (ABR) and speech perception in noise (SPiN) were associated with occupational noise exposure in normal hearing young factory workers. Forty young adults occupationally exposed to noise and 40 non-exposed young adults (control group) from Zhejiang province in China were selected. All participants presented with normal hearing thresholds and distortion product otoacoustic emissions. Participants were evaluated with the Mandarin Bamford-Kowal-Bench (BKB) test and ABR. The latter was obtained for click stimulus at 50, 60, 70, 80, and 90 dBnHL. Peak-to-trough amplitudes and latencies for waves I and V were obtained. The ABR wave I amplitude, the wave I/V amplitude ratio, the slope of the wave I amplitude growth as a function of stimulus intensity (AMP-ISlope), and the wave V latency shift with ipsilateral noise (LAT-VSlope) were used as ABR outcomes. Finally, equivalent continuous average sound pressure level normalized to 8 h (LAeq.8h) and cumulative noise exposure (CNE) were obtained for noise-exposed participants. No significant differences between groups were found for any ABR outcomes. Noise-exposed participants exhibited worse BKB scores than control group participants. A multivariate regression model showed that 23.3% of the variance in BKB scores was explained by group category (exposed vs. non-exposed) and hearing thresholds. However, since none of the ABR outcomes exploring cochlear synaptopathy were associated with noise exposure, we cannot conclude that cochlear synaptopathy was the contributing factor for the differences between groups for BKB scores. Factors that go beyond sensory processing may explain such results, especially given socio-economic differences between the noise-exposed and control groups. We conclude that in this sample of participants, occupational noise exposure was not associated with signs of cochlear synaptopathy as measured by ABR and BKB.

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Section: Auditory Brainstem Response Outcomesmentioning

confidence: 73%

Section: Auditory Brainstem Response Outcomesmentioning

confidence: 79%

Section: Auditory Brainstem Response Outcomesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

No effect of occupational noise exposure on auditory brainstem response and speech perception in noise

Pinsonnault-Skvarenina

Moïn-Darbari

Zhao

et al. 2022

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Therefore, a decrease in the amplitude of ABR wave I implies impairment of the inner hair cell, auditory nerve fiber, or the synapse between the two. In cochlear synaptopathy, the amplitude of ABR wave I decreases, whereas the amplitude of ABR wave V, the brainstem response, is maintained, or increases as a compensatory response, so the ratio of amplitudes, I/V, may also decrease [7,21]. Since in human studies, unlike animal experiments, synaptic loss cannot be directly observed, a decrease in amplitude of ABR wave I or the I/V ratio can be used as important evidence of cochlear synaptopathy.…”

Section: Discussionmentioning

confidence: 99%

Possible Existence of Cochlear Synaptopathy in Patients Completely Recovered from Idiopathic Sudden Sensorineural Hearing Loss

Seo

Lee

Byun

et al. 2022

JCM

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Cochlear synaptopathy refers to a subclinical hearing pathology which could potentially explain hearing difficulties within the normal hearing threshold; it is also called “hidden hearing loss”. We hypothesized that a temporary threshold shift in sudden sensorineural hearing loss (ISSNHL) also affects the function in the synapse. The aim of the study was to evaluate the presence of cochlear synaptopathy in patients who had completely recovered from unilateral SSNHL Nineteen patients who had completely recovered from ISSNHL from January 2018 to June 2021 were assessed. Complete recovery was established by pure tone audiometry (PTA) 3 months after treatment, according to the American Academy of Otolaryngology–Head and Neck Surgery criteria. Subjects completed the pure tone audiometry, speech audiometry and auditory brain stem response (ABR) test, and completed a questionnaire regarding hearing loss after hearing recovery. The ABR amplitudes of wave I and wave V, and the ratio of wave I/V of both ears (recovered side and healthy side) were assessed. A visual analog scale (VAS) and a hidden hearing loss questionnaire were used to evaluate subjective hearing difficulty. The ABR waves I of the recovered ears had a significantly lower amplitude (p = 0.002) than those of the healthy side, whereas there was no difference in wave V (p = 0.985) or in the ratio of wave I/V (p = 0.107). Some patients still felt mild hearing difficulty although their PTA results were normal, but there was no clear relationship between the VAS score, wave I amplitude and speech recognition scores. The present findings point to the possible existence of cochlear synaptopathy in ears that have completely recovered from unilateral sudden sensorineural hearing loss. We suggest that the causes of cochlear synaptopathy and of idiopathic sudden hearing loss may have something in common.

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Effects of 90 dB pure tone exposure on auditory and cardio-cerebral system functions in macaque monkeys

Zhi,

Li,

Wang

et al. 2024

Environmental Research

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ABR findings in musicians with normal audiogram and otoacoustic emissions: evidence of cochlear synaptopathy?

Cited by 8 publications

References 33 publications

No effect of occupational noise exposure on auditory brainstem response and speech perception in noise

No effect of occupational noise exposure on auditory brainstem response and speech perception in noise

Possible Existence of Cochlear Synaptopathy in Patients Completely Recovered from Idiopathic Sudden Sensorineural Hearing Loss

Effects of 90 dB pure tone exposure on auditory and cardio-cerebral system functions in macaque monkeys

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ABR findings in musicians with normal audiogram and otoacoustic emissions: evidence of cochlear synaptopathy?

Cited by 8 publications

References 33 publications

No effect of occupational noise exposure on auditory brainstem response and speech perception in noise

No effect of occupational noise exposure on auditory brainstem response and speech perception in noise

Possible Existence of Cochlear Synaptopathy in Patients Completely Recovered from Idiopathic Sudden Sensorineural Hearing Loss

Effects of 90 dB pure tone exposure on auditory and cardio-cerebral system functions in macaque monkeys

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Effects of 90 dB pure tone exposure on auditory and cardio-cerebral system functions in macaque monkeys