Abstract:The existence of a functional idiotypic network was postulated by Jerne (1) nearly one decade ago. Many experiments do indeed prove the feasibility of idiotypic manipulations of the immune system (see reference 2 for a review of this topic). It still remains to be established however, that idiotype-antiidiotype interactions play a major role in the ontogenesis of the immune system and that such interactions control its steady state. Information on these points may be gained from the characterization of idiotyp… Show more
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