ABP1–TMK auxin perception for global phosphorylation and auxin canalization

Friml, Jiřı́; Gallei, Michelle; Gelová, Zuzana; Johnson, Alexander; Mazur, Ewa; Monzer, Aline; Rodríguez, Lesia; Roosjen, Mark; Verstraeten, Inge; Živanović, B.; Zou, Minxia; Fiedler, Lukáš; Giannini, Caterina; Grones, Peter; Hrtyan, Mónika; Kaufmann, Walter A.; Kuhn, André; Narasimhan, Madhumitha; Randuch, Marek; Rýdza, Nikola; Takahashi, Koji; Tan, Shutang; Teplova, Anastasia; Kinoshita, Toshinori; Weijers, Dolf; Rakusová, Hana

doi:10.1038/s41586-022-05187-x

Cited by 98 publications

(122 citation statements)

References 58 publications

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“…7K), but the arrest of streaming was rare. Taken together, our data suggest that big mutants are defective in organelle movement within the cell, a function that is linked to the regulation of cytoplasmatic Ca 2+ levels and short-term auxin response (Friml et al, 2022).…”

Section: A-c)mentioning

confidence: 58%

“…The cytoplasm of plant cells continuously undergoes intracellular flow, promoted by the activity of myosin motors. This flow is arrested when cytosolic Ca 2+ concentrations are elevated (Tominaga & Ito, 2015) and enhanced in response to exogenous auxin (Friml et al ., 2022). The observed arrest of Golgi and ER movement can be due to a specific effect on the ER or due to general arrest in cytoplasmic streaming and organelle movement.…”

Section: Resultsmentioning

confidence: 99%

“…It was recently shown that auxin response enhances the rates of cytoplasmatic streaming and mutants which are defective in this response have lower rates of vasculature reconnection following injury, supporting the link between auxin response, cytoplasmic streaming, and downstream developmental responses (Friml et al, 2022). However, it is still unclear how and if Ca 2+ levels and changes in cytoplasmatic streaming rates are translated to changes in development.…”

Section: Discussionmentioning

confidence: 99%

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Mapping of the Classical Mutation rosette Highlights a Role for Calcium in Wound-induced Rooting

Modrego

Pasternak

Omary

et al. 2022

Preprint

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Removal of the root system induces the formation of new roots from the remaining shoot. This process is primarily controlled by the phytohormone auxin which interacts with other signals in a yet unresolved manner. Here, we study the classical tomato mutation rosette (ro) which lacks shoot-borne roots. ro plants were severely inhibited in the formation of wound-induced roots and have reduced rates of auxin transport. We mapped ro to the tomato ortholog of the Arabidopsis thaliana BIG and the mammalians UBR4/p600. RO/BIG is a large protein of unknown biochemical function. In A. thaliana, BIG was implicated in the regulation of auxin transport and calcium homeostasis. We show that exogenous calcium inhibits wound-induced root formation in both tomato and A. thaliana ro/big mutants. Exogenous calcium antagonized the root-promoting effects of the auxin IAA, but not of 2,4-D, an auxin analog that is not recognized by the polar transport machinery, and accumulation of the auxin transporter PIN1 was sensitive to calcium levels in the ro/big mutants. Consistent with a role for calcium in mediating auxin transport, both ro/big mutants and calcium-treated wild-type plants were hypersensitive to treatment with polar auxin transport inhibitors. Subcellular localization of BIG suggests that like its mammalian ortholog, it is associated with the endoplasmic reticulum (ER). Analysis of subcellular morphology revealed that ro/big mutants exhibited disruption in cytoplasmic streaming. We suggest that RO/BIG maintain auxin flow by stabilizing PIN membrane localization, possibly by attenuating the inhibitory effect of Ca2+ on cytoplasmic streaming.

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Section: A-c)mentioning

confidence: 58%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mapping of the Classical Mutation rosette Highlights a Role for Calcium in Wound-induced Rooting

Modrego

Pasternak

Omary

et al. 2022

Preprint

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“…In Arabidopsis, ABP1 is secreted and binds specifically to the native auxin IAA at the typical acidic pH. These findings indicate that ABP1 is the auxin receptor for TMK1-based cell surface signaling, which mediates the global phospho-response and auxin canalization [ 30 , 31 ]. Both IAA and melatonin, therefore, play important roles in plant growth and resilience by interacting with MAPK kinases ( Figure 3 ).…”

Section: Iaa Signaling In Plantsmentioning

confidence: 99%

Melatonin and Indole-3-Acetic Acid Synergistically Regulate Plant Growth and Stress Resistance

Zhang

Gao

et al. 2022

Cells

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Plant growth and development exhibit plasticity, and plants can adapt to environmental changes and stress. Various phytohormones interact synergistically or antagonistically to regulate these responses. Melatonin and indole-3-acetic acid (IAA) are widespread across plant kingdom. Melatonin, an important member of the neuroendocrine immune regulatory network, can confer autoimmunity and protect against viral invasion. Melatonin functions as a plant growth regulator and biostimulant, with an important role in enhancing plant stress tolerance. IAA has a highly complex stress response mechanism, which participates in a series of stress induced physiological changes. This article reviews studies on the signaling pathways of melatonin and IAA, focusing on specific regulatory mechanisms. We discuss how these hormones coordinate plant growth and development and stress responses. Furthermore, the interactions between melatonin and IAA and their upstream and downstream transcriptional regulation are discussed from the perspective of modulating plant development and stress adaptation. The reviewed studies suggest that, at low concentrations, melatonin promotes IAA synthesis, whereas at high levels it reduces IAA levels. Similarly to IAA, melatonin promotes plant growth and development. IAA suppresses the melatonin induced inhibition of germination. IAA signaling plays an important role in plant growth and development, whereas melatonin signaling plays an important role in stress responses.

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“…It should, therefore, not have come as too much of a surprise to see the recent rehabilitation of ABP1, which has included a new study published last month in Nature 15 . Using clean mutants and modern approaches such as ultrafast phosphoproteomics, the authors demonstrate that auxin induces phosphorylation of a thousand sites after two minutes, but that this response is almost entirely blocked in both abp1 and tmk1 mutants.…”

mentioning

confidence: 99%

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2022

Nat. Plants

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ABP1–TMK auxin perception for global phosphorylation and auxin canalization

Cited by 98 publications

References 58 publications

Mapping of the Classical Mutation rosette Highlights a Role for Calcium in Wound-induced Rooting

Mapping of the Classical Mutation rosette Highlights a Role for Calcium in Wound-induced Rooting

Melatonin and Indole-3-Acetic Acid Synergistically Regulate Plant Growth and Stress Resistance

Science is a rollercoaster

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