Above the Regular Tide: Primary Immune Regulatory Disorders (PIRD) Diagnosis and Treatment Considerations

Chitty-Lopez, Maria; Imanirad, Donya; Leiding, Jennifer W.

doi:10.1016/b978-0-12-818731-9.00232-9

Cited by 1 publication

(1 citation statement)

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“…The release of inflammatory cytokines and the activation of APCs, such as macrophages and dendritic cells, are just two of the many outcomes of innate immune responses. These nonclonal responses also shape the immune system in preparation for the later emergence of certain adaptive immunological responses [ 12 , 13 ]. Vaccine development prioritizes adjuvants, which boost antigen immunogenicity.…”

Section: Resultsmentioning

confidence: 99%

Induction of Innate and Adaptive Immune Response against Recombinant HBsAg Protein Entrapped in Docosahexaenoic Acid Nanovesicles through Biomarkers

et al. 2023

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The present study focused on demonstrating the induction of humoral and cell-mediated immunity through the establishment of a cytokine network. We hypothesized the anti-inflammatory, pro-inflammatory, and IgE antibody levels after vaccination with lyophilized recombinant HBsAg-loaded docosahexaenoic acid nanovesicles (LRPDNV), and the efficacy compared well with standard commercial recombinant hepatitis B vaccine. The cytokine network was efficiently regulated by striking a balance between pro-inflammatory cytokines IL-6, IL-8R, and IL-12 and anti-inflammatory cytokines such as IL-2, IL-4, IL-10, and IFN-γ immune response on the 14th and 30th day after primary and booster immunization. The acute phase protein CRP level was increased due to IL-6 after immunizing with LRPDNV. On the other hand, the IgE level was not significantly increased to induce any allergic reactions after immunization with LRPDNV. The study concluded that after immunizing with LRPDNV, a significant immunological response was established, implying that DHA nanovesicles have significant potential as an adjuvant method for delivering recombinant HBsAg protein. On the other hand, following immunization with LRPDNV, the IgE level was not noticeably elevated enough to cause any adverse reactions. The study concludes that a robust immune response was developed after immunizing with LRPDNV and suggests that DHA nanovesicles have much potential to deliver recombinant HBsAg protein.

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Section: Resultsmentioning

confidence: 99%