About the influence of the colloidal magnetic nanoparticles coating on the specific loss power in magnetic hyperthermia

Osaci, Mihaela; Cacciola, Matteo

doi:10.1016/j.jmmm.2020.167451

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…The saturation magnetisation (M S ) values from the magnetisation curves were found to be 1. 13 Table 1). The blocking temperature (T B ) is a crucial factor that must be addressed in the case of biomedical applications because of the importance of the superparamagnetic behaviour of the particles.…”

Section: Magnetic Properties Of Dex-coated Mnpsmentioning

confidence: 99%

“…The term specific absorption rate (SAR) more precisely defines this relationship as the amount of heat released by a unit weight of the material per unit time during exposure to an AMF of defined frequency ( f ) and field strength ( H ) [ 11 ]. Apart from the application parameters ( H and f ), the SAR also depends on the magnetic component characteristics, such as particle size, distribution, shape and magnetic properties of MNPs, including coating/surfactant properties, which affect the hydrodynamic size and carrier liquid viscosity [ 5 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

et al. 2020

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Dextran-coated magnetic nanoparticles are promising biocompatible agents in various biomedical applications, including hyperthermia and magnetic resonance imaging (MRI). However, the influence of dextran molecular weight on the physical properties of dextran-coated magnetic nanoparticles has not been described sufficiently. We synthesise magnetite nanoparticles with a dextran coating using a co-precipitation method and study their physical properties as a function of dextran molecular weight. Several different methods are used to determine the size distribution of the particles, including microscopy, dynamic light scattering, differential centrifugal sedimentation and magnetic measurements. The size of the dextran-coated particles increases with increasing dextran molecular weight. We find that the molecular weight of dextran has a significant effect on the particle size, efficiency, magnetic properties and specific absorption rate. Magnetic hyperthermia measurements show that heating is faster for dextran-coated particles with higher molecular weight. The different molecular weights of the coating also significantly affected its MRI relaxation properties, especially the transversal relaxivity r2. Linear regression analysis reveals a statistically significant dependence of r2 on the differential centrifugal sedimentation diameter. This allows the targeted preparation of dextran-coated magnetic nanoparticles with the desired MRI properties. These results will aid the development of functionalised magnetic nanoparticles for hyperthermia and MRI applications.

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Section: Magnetic Properties Of Dex-coated Mnpsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

et al. 2020

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“…We started from a model already used in various studies and evaluations in the specialized literature (Osaci and Cacciola 2015;Osaci and Cacciola 2017;Osaci and Cacciola 2021;Osaci and Cacciola 2021a;Osaci and Cacciola 2020). In our model, we replaced the evaluation of the Brownian relaxation time by the usual Debye with Equations (2)-( 6), which take into account both the concentration of particles in the nanofluid and the applied magnetic field.…”

Section: The Semi-analytical Modelmentioning

confidence: 99%

Understanding the Effect of Magnetic Field and Nanoparticle Concentration on Brownian Relaxation Time in Magnetic Nanofluids: A Semi-Analytical Model

Osaci

Cacciola

2023

Preprint

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Magnetic nanofluids are used in many types of applications. Therefore, the dynamics of magnetic nanoparticle systems under the action of magnetic field were intensively studied, lately. Many studies related to biomedical applications consider the Brownian relaxation time independent from the magnetic field and nanoparticle concentration. This modelling assumption can lead to certain errors in the estimation of some parameters of interest. Thus, these errors also propagate in the determination of the effective relaxation time, which is of great importance in the estimation of some quantities of interest such as SAR (Specific Absorption Rate) or ILP (Intrinsic Loss Power Values) for magnetic hyperthermia. This paper presents a study of these errors starting from a semi-analytical model. Our experimental results can be useful to understand the mechanisms of magnetic relaxation of a nanofluid in various conditions and, above all, to create suitable numerical evaluation models.

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“…Surface coating is one of the strategies used to overcome these drawbacks, allowing protection from oxidation, improving biocompatibility, and enhancing their colloidal stability [13,19].…”

Section: Introductionmentioning

confidence: 99%

Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

et al. 2021

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Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m−1 and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm2kg−1, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.

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About the influence of the colloidal magnetic nanoparticles coating on the specific loss power in magnetic hyperthermia

Cited by 13 publications

References 22 publications

Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

Understanding the Effect of Magnetic Field and Nanoparticle Concentration on Brownian Relaxation Time in Magnetic Nanofluids: A Semi-Analytical Model

Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

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