2007
DOI: 10.1021/ja066313x
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About Long-Lived Nuclear Spin States Involved in Para-Hydrogenated Molecules

Abstract: This study deals with a spin system constituted of three nonequivalent protons, two of them originating from para-hydrogen (p-H(2)) after a hydrogenation reaction carried out in the earth magnetic field. It is shown that three singlet states are created provided indirect (J) couplings exist between the three spins, implying hyperpolarization transfer toward the third spin. Upon insertion of the sample in the NMR (Nuclear Magnetic Resonance) high field magnet, the following events occur: (i) the longitudinal tw… Show more

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Cited by 59 publications
(56 citation statements)
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References 15 publications
(24 reference statements)
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“…The relaxation properties of LLS are favorable because these states are not affected by dipolar interactions between the spins involved. In some systems, the LLS can be boosted by magnetization transferred from para-hydrogen (23,24). In selected molecules featuring chemically equivalent nuclei, spin states with relatively long lifetimes are believed to exist that may be converted into detectable magnetization through a hydration reaction (25).…”
mentioning
confidence: 99%
“…The relaxation properties of LLS are favorable because these states are not affected by dipolar interactions between the spins involved. In some systems, the LLS can be boosted by magnetization transferred from para-hydrogen (23,24). In selected molecules featuring chemically equivalent nuclei, spin states with relatively long lifetimes are believed to exist that may be converted into detectable magnetization through a hydration reaction (25).…”
mentioning
confidence: 99%
“…A ratio as high as T LLS /T 1 = 25 has been found in the Ala-Gly dipeptide. [25] One of the three spin systems studied herein, acrylic acid, had been shown by Canet et al [23] to possess long lifetimes that can be used to preserve magnetisation enhanced by a chemical reduction with para-hydrogen. The structure of acrylic acid, along with its 1D spectrum, is shown in Figure 1.…”
mentioning
confidence: 97%
“…[21,22] Some LLS can be enhanced by magnetisation transferred from para-hydrogen. [23,24] We have recently found that slow diffusion rates of biomolecules may be determined with moderate gradient strengths. Long-lived states can be excited and sustained for the diastereotopic pairs of protons {H a1 , H a2 } in glycine residues.…”
mentioning
confidence: 99%
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“…It was shown that long-lived spin states may be obtained in systems with more than two coupled spins, and that these states may be used to preserve enhanced polarisation. [13][14][15][16][17] Besides their utility for the study of slow exchange and transport phenomena, 12,[18][19][20][21] with ratios as large as T LLS /T 1 = 37 observed in pairs of diastereotopic protons in a partially deuterated saccharide, long-lived states were also shown to be useful for the study of molecular geometry. 22,23 An experiment combining both dissolution DNP and LLS has been designed where the magnetisation was transferred from a polarised carbonyl 13 C (in natural abundance) to a pair of nearby H a protons in the dipeptide Ala-Gly and stored in the form of a long-lived proton state with T LLS = 16 s in water at 298 K and 300 MHz (the ratio T LLS /T 1 = 7 is expected to be further increased if the free radicals in the solution were quenched with sodium ascorbate).…”
mentioning
confidence: 99%