Abordagens divergentes na preparação de alcaloides indolizidínicos

Abstract

Herein were described three diverted oriented approaches for the construction of the bicyclic scaffold of indolizidines alkaloids, that figures between one of the most important classes of natural products. In the first approach, a new method to prepare α,β-unsaturated diazoketones was described using the Horner-Wadsworth-Emmons (HWE) reaction between diazophosphonate and aldehydes. The unsaturated diazoketones were used as powerful plataforms to construct the indolizidine carbocyclic scaffold, enploying the Wolff rearrangement as the key step. The second approach was the development of a reductive coupling between α-aminocarbonyl derivatives and methyl acrylate, mediate by SmI 2 , from this approach, the well-known advanced intermediate for the synthesis of (-)-pumiliotoxin 251D e of the (+/-)-epiquinamide was obtained in only two steps. The third approach uses the intermolecular Wittig/HWE reaction as the key step in the construction of a bicyclic intermediate containing an α,β-unsaturated moiety that could be used for a diverted oriented approach in the indolizidine alkaloids synthesis.

Correlation Between Anthropometric Parameters And Biochemical Markers Of Cardiovascular Risk In Chronic Renal Patients On Hemodialysis

“…1,2 In Brazil, studies have shown that its incidence is 8% per year. 3 Hemodialysis being the most frequent treatment among these patients, with an average of 93.2% between 2010 and 2017. CKD has been described as one of the main determinants of cardiovascular disease (CVD) risk, which is the leading cause of mortality in renal replacement therapy (RRT) patients, resulting in a prevalence of 126,583,000 patients.…”