ABO/Rhesus Blood Group and Correlation with Sickle Cell Disease and Type-II Diabetes Mellitus in South East and South-South of Nigeria

Alagwu, E A; Akukwu, Darlington Cyprain; Ngwu, E. E.; Uloneme, G. C.

doi:10.20510/ukjpb/4/i5/134669

Cited by 4 publications

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“…Similarly, while carrying out the frequency of the blood group distribution among our cohort, it was revealed that O and A blood group individuals are mostly associated with genotype SS (SCD), followed by B, and the least prevalent is AB. Again, this agrees with the study performed by Alagwu et al [15].…”

Section: Discussionsupporting

confidence: 93%

A Cross Sectional Study of Association of HLA typing with Haemoglobin Level in Sickle Cell Anaemia

Alserihi

Kabrah

Alsadoun

2021

JPRI

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Background: Sickle-cell Disease (SCD) is the most common blood cell disorder affecting millions of people. In severe cases, regular blood transfusion is an essential practice to relieve clinical symptoms. However, since regular blood transfusion can lead to alloimmunization to foreign human leukocyte antigens (HLA), this may result in severe anemia due to red blood cell destruction. Therefore, this study aimed to determine the association between the hemoglobin level and the presence of HLA genotypes among Sickle Cell Anemia patients. Methodology: A total of 64 SCD patients and 21 healthy donors seen at King Abdulaziz hospital between November 2019 and February 2021 were recruited for this study. Demographic data including ABO/Rhesus blood groups, hemoglobin concentration, were among the clinical information obtained. HLA genotyping was performed using Polymerase Chain Reaction-Sequence Specific Oligonucleotide (PCR-SSO). The data were cleaned using the Microsoft Excel and analysed using the statistical packages for Social Sciences (SPSS) version 24. Results: The incidence of SCD is not strictly gender-related because of its transmission as an autosomal recessive disorder. Sixty-four individuals (33 females; 31 males) having SCD were analyzed. O blood group recorded the highest prevalence compared to other ABO blood groups in SCD patients. After analysing allelic association, HLA-A*02 was more frequent in SCD patients compared to control. After further allelic combination analysis of patients and compared with the control group, HLA-DQB1*02 was majorly involved in overexpression and decreasing hemoglobin level and significantly different among control and experimental groups. Conclusion: Rhesus-positive blood types were more associated with the SCA. HLA- type II alleles could influence the clinical course of sickle cell disease and HLA-DQB1*02 was significantly different among SCD group and control individuals, which signifies the concept that the allele was overexpressed among patients resulting in low Hb level.

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Section: Discussionsupporting

confidence: 93%

A Cross Sectional Study of Association of HLA typing with Haemoglobin Level in Sickle Cell Anaemia

Alserihi

Kabrah

Alsadoun

2021

JPRI

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“…We further determined that most patients with SCD had type O RhD+ blood and that this variable varied significantly between the two groups (P = 0.022). This result was consistent with the findings of Alagwu et al [30] who reported an O blood group frequency of 63% among Hb-ss patients. This finding could be explained by the fact that the O Rh+ blood group is the most prevalent group in humans.…”

Section: Discussionsupporting

confidence: 93%

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

Alzahrani¹,

Algarni²,

Alnashri³

et al. 2020

Cureus

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Objectives: Previous studies have not addressed microalbuminuria in pediatric patients with sickle cell disease (SCD) in Jeddah, Saudi Arabia. This study aimed to determine the prevalence of microalbuminuria and to identify associated risk factors in children with SCD at King Abdulaziz University Hospital.Results: Overall, 42.5% of the patients enrolled were Saudi Arabian and 51% were male. The mean age was 12.4 years, and the highest percentage (40%) was in the age group of 15-18 years. The prevalence of microalbuminuria was 9.6%, and hematuria was present in 8% of cases. The percentage of patients with hematuria was significantly higher in the microalbuminuria group (22.6%) than in the nonmicroalbuminuria group (6.5%; P = 0.007). The percentage of patients with acute chest syndrome was also higher in the microalbuminuria group (26%) than in the nonmicroalbuminuria group (8%; P = 0.005). The percentage of patients with gallbladder stones was higher in the microalbuminuria group (13%) than in the nonmicroalbuminuria group (2.4%; P = 0.014). However, the mean number of blood transfusions was higher in the nonmicroalbuminuria group than in the microalbuminuria group (P = 0.002). Sickle cell nephropathy manifests as microalbuminuria, begins at an early age, occurs in all types of SCD, and is associated with disease severity.

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Influence of ABO blood groups and demographic characteristics on the prevalence of type 2 diabetes in Lagos, southwest Nigeria

et al. 2021

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Background The literature shows that ABO blood groups and demographic characteristics influence susceptibility to type 2 diabetes mellitus (T2DM) and may be used to stem the rising incidence of the disease. However, these associations vary geographically, which necessitates the need to determine the association in every locality. This study determined the ABO blood groups and demographic characteristics of 486 type 2 diabetic patients with no family history in selected hospitals in Lagos, Nigeria. Results The results showed that age class 50–59 years (35.8%) was the most susceptible to T2DM, while age class 30–39 years (8.6%) was the least. Female diabetics accounted for 56.8%, while males constituted 43.2%. Diabetes was less prevalent among singles (9.5%), while married couples had the highest prevalence (55.6%). Primary school leavers were the least diabetic (9.9%), while secondary school leavers were the most diabetic (41.6%). Approximately 59.05% of the patients were overweight, while 5.35% were underweight. Blood group O positive was the most prevalent (38.5%; p < 0.05), followed by A positive (20.2%; p < 0.05), and the least was AB negative (4.5%). Severe conditions were less common among groups O positive and A positive (p < 0.05) compared to other blood groups. Thus, the relatively high prevalence of T2DM among blood groups O and A could be due to natural selection owing to their fitness. Conclusions ABO blood groups and demographic characteristics influenced the prevalence of T2DM in the city. Residents with blood groups O and A positive should pay special attention to T2DM.

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ABO/Rhesus Blood Group and Correlation with Sickle Cell Disease and Type-II Diabetes Mellitus in South East and South-South of Nigeria

Cited by 4 publications

References 0 publications

A Cross Sectional Study of Association of HLA typing with Haemoglobin Level in Sickle Cell Anaemia

A Cross Sectional Study of Association of HLA typing with Haemoglobin Level in Sickle Cell Anaemia

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

Influence of ABO blood groups and demographic characteristics on the prevalence of type 2 diabetes in Lagos, southwest Nigeria

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