ABO-incompatible kidney transplantation: Indian working group recommendations

Bhalla, AK; Kumar, BT Anil; Chauhan, Munish; Das, Pratik; Gandhi, Bhupendra; Hegde, Umapati; Jeloka, Tarun; Mali, Manish; Jha, Pranaw Kumar; Kher, Ajay; Mukkavilli, Kamal Kiran; Ramachandran, Raja; Jha, Vivekanand

doi:10.4103/ijot.ijot_39_19

Indian J Transplant

2019

DOI: 10.4103/ijot.ijot_39_19

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ABO-incompatible kidney transplantation: Indian working group recommendations

AK Bhalla

BT Anil Kumar

Munish Chauhan

et al.

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“…The first ABOi kidney transplantation in India was done successfully at Christian Medical College Vellore on April 23, 2009 without splenectomy. ABOi kidney transplantations are performed more often today[ 1 - 3 ] all over India.…”

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The first ABO incompatible kidney transplantation without splenectomy in India – A review at 12 years

et al. 2023

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The first ABO incompatible kidney transplantation without splenectomy in India – A review at 12 years

et al. 2023

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Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment

et al. 2022

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ABO blood group antibodies have not been generated or are at low titer during early infancy. Therefore, in theory, ABO-incompatible kidney transplantation (ABOi KT) may be successfully achieved in small infants without any pre-transplant treatment. We report here the first ABO-incompatible deceased donor kidney transplantation (ABOi DDKT) in an infant. The recipient infant was ABO blood group O, and the donor group A. The recipient was diagnosed with a Wilms tumor gene 1 (WT1) mutation and had received peritoneal dialysis for 4 months prior to transplant. At 7 months and 27 days of age, the infant underwent bilateral native nephrectomy and single-kidney transplantation from a 3-year-old brain-dead donor. No pre- or post-transplantation antibody removal treatment was performed, since the recipient's anti-iso-hemagglutinin-A Ig-M/G antibody titers were both low (1:2) before transplantation and have remained at low levels or undetectable to date. At 11 months post-transplant, the recipient is at home, thriving, with normal development and graft function. This outcome suggests that ABOi DDKT without antibody removal preparatory treatment is feasible in small infants, providing a new option for kidney transplantation in this age range.

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ABO-incompatible kidney transplantation: Indian working group recommendations

Cited by 2 publications

References 28 publications

The first ABO incompatible kidney transplantation without splenectomy in India – A review at 12 years

The first ABO incompatible kidney transplantation without splenectomy in India – A review at 12 years

Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment

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