ABO incompatible blood transfusion

Sources of preventable errors related to transfusion

“…In 1981, an editorial [17] highlighted the disastrous results of mismatched transfusion in Great Britain. Murphy & McClelland [15] published a review of five transfusion reactions based on a 24‐month study in a large teaching hospital in the UK; Bacon & Young [18] reported four similar incidents in Australia. In addition, several publications from the USA [19–21] reported that the majority of transfusion errors occured at the bedside of the patient.…”

Initiation and Regulation of Complement during Hemolytic Transfusion Reactions

“…Robust complement activation not only results in significant intravascular hemolysis, but complement products also independently induce significant physiological changes. Indeed, early transfusion reactions likely reflected significant complement-mediated hemolysis and systemic alterations that ultimately resulted in fatal outcomes [15–18]. …”

Mismatched transfusion of 8 AB0-incompatible units of packed red blood cells in a patient with acute intermittent porphyria

“…[268] Lethal processes without direct connection with the transfusion occurred after 9 and 15 units. [212] After 4×1, 2, 2×3, and 4 units[12467111314] it came to serious complications, and without consequences remained the mismatched transfusion of 3×1, 3, and 7 units. [239–11] This represents a rate of 5.3% with fatal outcome.…”