Coombs test was carried out on infants' cells sensitized in mothers' serum. No other incompatibility was detected.So far as we are able to analyse the figures, the first period, as shown above, consistently yields a fairly highly significant excess of 0 in toxaemia, the second period equally consistently yielded no such excess. It may be that there is a phenomenon to explain, but on the present evidence it seems likely that the original finding was due to chance. This experience serves to emphasize the need for large numbers in work in this field, the desirability of demanding a high level of significance before results are taken as more than an indication for further inquiry, and also the desirability of comparing results from different hospitals and different areas. Summary A further series does not confirm the finding (Pike and Dickins, 1954) that there is an excess of women of group 0 among those suffering from toxaemia of pregnancy. In a study of 541 patients with toxaemia of pregnancy, Pike and Dickins (1954) found a significant excess of women of blood group 0 as compared with nontoxaemic pregnant women. It was suggested that some of the features of toxaemia might be the result of an antigen-antibody reaction. We thought it would be of interest to repeat their investigation on a similar series of patients admitted to another hospital.
MaterialThe investigation was carried out on 11,086 consecutive admissions to the maternity department of Hammersmith Hospital between 1949 and 1954.The majority of patients, both primigravidae and multiparae, are booked for delivery at this hospital in order of their application for admission at the antenatal clinic. Patients attending for the first time in late pregnancy are admitted on obstetrical, medical, or social grounds only.For the purposes of this investigation and in order to conform with the criteria selected by Pike and Dickins, patients were regarded as having toxaemia of pregnancy if they showed two of the following signs: (1) a blood pressure of 140/90 or over after the 28th week of pregnancy; (2) clinical oedema or an average weight gain of more than 2 lb. (0.9 kg.) a week from the 28th week; (3) albuminuria in a catheter specimen, not due to infection. The level of weight gain which we regarded as significant in the absence of clinical oedema was greater than that selected by Pike and Dickins, but otherwise our criteria were identical wvith theirs.
Results