ABO blood groups and hemoglobin variants among Nubians, Egypt, U.A.R.

Awny, A. Y.; Kamel, Karim; Hoerman, Kirk C.

doi:10.1002/ajpa.1330230129

Cited by 10 publications

(6 citation statements)

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“…The first case of SCA in Egypt was reported in 1951 by Abbasy88. Other abnormalities of haemoglobin were also identified89. Since then, several studies have been carried out and shown that, in Egypt, β-thalassaemia is the most common type with a carrier rate varying from 5.3-9 per cent and a gene frequency of 0.03.…”

Section: Frequency and Distribution Of Sickle Cell Gene Among Arabsmentioning

confidence: 99%

Sickle cell disease in Middle East Arab countries

El‐Hazmi¹,

Al-Hazmi²,

Warsy³

2011

Indian J Med Res

120

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The sickle cell (HbS) gene occurs at a variable frequency in the Middle Eastern Arab countries, with characteristic distribution patterns and representing an overall picture of blood genetic disorders in the region. The origin of the gene has been debated, but studies using β-globin gene haplotypes have ascertained that there were multiple origins for HbS. In some regions the HbS gene is common and exhibits polymorphism, while the reverse is true in others. A common causative factor for the high prevalence and maintenance of HbS and thalassaemia genes is malaria endemicity. The HbS gene also co-exists with other haemoglobin variants and thalassaemia genes and the resulting clinical state is referred to as sickle cell disease (SCD). In the Middle Eastern Arab countries, the clinical picture of SCD expresses two distinct forms, the benign and the severe forms, which are related to two distinct β-globin gene haplotypes. These are referred to as the Saudi-Indian and the Benin haplotypes, respectively. In a majority of the Middle Eastern Arab countries the HbS is linked to the Saudi-Indian haplotype, while in others it is linked to the Benin haplotype. This review outlines the frequency, distribution, clinical feature, management and prevention as well as gene interactions of the HbS genes with other haemoglobin disorders in the Middle Eastern Arab countries.

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Section: Frequency and Distribution Of Sickle Cell Gene Among Arabsmentioning

confidence: 99%

Sickle cell disease in Middle East Arab countries

El‐Hazmi¹,

Al-Hazmi²,

Warsy³

2011

Indian J Med Res

120

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“…It varies from race to race, one country to another and even in different regions of a country. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] This spectrum of difference may be attributed to genetic factors and natural selection which is affected mainly by traditions and habits namely exogamy and endogamy. Global frequency pattern of the type B blood allele is highest in central Asia and in few pockets of Africa but lowest in the America and Australia.…”

Section: Introductionmentioning

confidence: 99%

Distribution Of Phenotypic And Genotypic Abo And Rhesus Blood Groups Among Bangladeshi Population

Dipta

Iqbal

Hossain

et al. 1970

Ibrahim Med. Coll. J.

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The present study is a retrospective analysis of allelic frequency of ABO and Rhesus (D) blood groups of donors attending the Deaprtment of Transfusion Medicine of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka. BIRDEM IS a 625 bed hospital, where patients and blood donors come from all parts of Bangladesh. A total of 1, 28,506 blood donors of both genders were included in the study over fourteen years from June 1995 to June 2009 for analysis. Blood group was determined by performing the both tube and slide method blood grouping method. The distribution of blood groups in our population was B>O>A>AB in Rh positive groups donors and O>B>A>AB among Rh negative donors. Blood group B was more common among the males (37.42%) while O was predominant among female donors (33.83 %). On the other hand, blood group O negative was predominant in both genders (36.88%). In this study, Hardy-Weinberg equilibrium law was used to calculate the allelic frequency for ABO/ Rh system. Homozygous allelic frequency for Rh negative population was only 0.0007. Although phenotypically B group was dominant and AB was rare in our population, but according to Hardy-Weinberg equilibrium law the estimated allelic frequency of A (0.3694) and O (0.3040) showed higher frequency than B type (0.2300) in Bangladeshi population in both homozygous and heterozygous state. So, with increasing population of Bangladesh, this changing trend in estimated blood group in ABO system may play an important role in our genetic pattern.Ibrahim Med. Coll. J. 2011; 5(2): 59-62

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“…The scarcity or absence of Hb H in Egypt is substantiated by a similar finding in surveys and studies which covered the majority of Egyptian territories (Kamel et al, 1960;Awny, Kamel, and Hoerman, 1965;Kamel, 1968;Azim et al, 1974;Ibrahim et al, 1974;Selim et al, 1974) as well as in neighbouring Libya (Kamel etal, 1975).…”

Section: Discussionmentioning

confidence: 64%

Absence of the -thalassaemia syndromes in Egyptian Arabs

Selim¹,

Kamel²,

Sabry³

et al. 1974

Journal of Medical Genetics

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Summary. An investigation was undertaken to find the incidence of a-thalassaemia in Egypt. Blood was collected from the umbilical cords of 550 newborns and from 630 adults from central hospitals in Cairo that drain patients from all over Egypt.Starch gel electrophoreses at both pH 8-6 and 7.0, and brilliant cresyl blue incubation revealed the absence of haemoglobins Barts and H in the blood specimens examined.While much is known on the genetic, clinical, and chemical variations of the 3-thalassaemias and their combinations with other haemoglobinopathies, corresponding information on the a-thalassaemias is at best fragmentary and unclear.It is now an accepted fact that haemoglobins Barts and H result from a reduction of a-chain syn-

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ABO blood groups and hemoglobin variants among Nubians, Egypt, U.A.R.

Cited by 10 publications

References 1 publication

Sickle cell disease in Middle East Arab countries

Sickle cell disease in Middle East Arab countries

Distribution Of Phenotypic And Genotypic Abo And Rhesus Blood Groups Among Bangladeshi Population

Absence of the -thalassaemia syndromes in Egyptian Arabs

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