ABO blood group influence COVID-19 infection: a meta-analysis

Huaqiang, Wang; Zhang, Jiajuan; Lu, Jianyi; Ai, Jun; Yu, Yuecheng; Wang, Maorong; Li, Ping

doi:10.3855/jidc.13815

Cited by 11 publications

(11 citation statements)

References 27 publications

(37 reference statements)

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“…The most common viral marker was HBsAg (0.38%), followed by anti-HCV (0.13%), syphilis (0.02%), and anti-HIV (0.006%), and male donors were more infected than female donors [ 37 ]. One recent example was the association of ABO groups with COVID-19, suggesting that those with group A and AB are more prone to the infection, while those with group O are less susceptible [ 38 ]. This study showed that donors with the O blood group, particularly those with O RhD +ve blood group, were more at risk of developing TTIs, whereas donors with the AB blood group, the AB RhD −ve blood group, in particular, were at the lowest risk of developing TTIs.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors in the Western Region of Saudi Arabia: A 7-Year Retrospective Analysis

et al. 2022

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This study was aimed at determining the prevalence estimate and association of transfusion-transmitted infections (TTIs) with ABO and Rh blood groups among blood donors at the King Faisal Specialist Hospital and Research Center (KFSH & RC) in the western region of Saudi Arabia. A retrospective study was conducted at the blood bank center of KFSH and RC from 1 January 2013 to 31 December 2019. Data on ABO and Rh blood group testing, serological testing, molecular investigations, serological assays, nucleic acid testing (NATs), and socio-demographic information were gathered. During the study period, there were 959,431 blood donors at the KFSH and RC. The overall 7-year cumulative prevalence estimate of blood transfusion-transmitted infections among blood donors was low at 7.93%, with an average prevalence estimate of 0.66%. Donors with the O blood group, the O RhD +ve blood group, in particular, were more at risk of developing TTIs, whereas donors with the AB blood group, the AB RhD −ve blood group, in particular, were at the lowest risk of developing TTIs. In total, 96.9% of the blood donors were males (n = 916,567). Almost half of the blood donors belong to the O blood group (49.4%). A total of 861,279 (91.0%) donors were found to be RhD positive. The percentages of TTIs were found to be higher in RhD +ve donors compared with RhD −ve donors. The prevalence estimate of the hemoglobin C (HbC) infection was the most common TTI among the blood donors being 3.97%, followed by malaria being 2.21%. The least prevalence estimate of TTI in the present study was for NAT HIV being 0.02%. Significant associations were observed between RhD +ve and RhD −ve among the malaria-infected donors (A: χ2 = 26.618, p = 0.001; AB: χ2 = 23.540, p = 0.001; B: χ2 = 5.419, p = 0.020; O: χ2 = 68.701, p = 0.001). The current 7-year retrospective study showed a low level of TTIs among blood donors. However, we urge that more research encompassing the entire country be conducted in order to obtain more representative results in terms of the prevalence estimate and association of transfusion-transmitted infections with ABO and Rh blood groups in communities.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors in the Western Region of Saudi Arabia: A 7-Year Retrospective Analysis

et al. 2022

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“…The RBC surface of blood group A contains antigen A and the serum/plasma contains anti-B antibodies. Blood group A has been linked to a higher risk of HIV [ 10 , 11 ], HBV [ 11 ], HCV [ 12 ], COVID-19 [ 13 , 14 ], malaria, smallpox, enterotoxoid-mediated cholera, glue ear, capsular glaucoma, and heart disease, as well as a number of cancers, including gastric, breast, ovarian, cervical, leukemia (ALL), and leukemia of the pancreas[ 8 ], HCV related hepatocellular carcinoma (HCC)[ 15 ] Non-secretors of blood group A are linked to non-insulin-dependent diabetes, ankylosing spondylitis, Graves' disease, and coeliac disease [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Our study result shows that blood group B had a significantly higher frequency of 39.92% for blood issues (p = 0.0000) and 39.34% for platelet (RDP) issues (p = 0.0000) and a lower frequency of 37.32% for FFP issues (p = 0.00024), compared to the frequency of blood donors at 37.53%.The RBC surface of blood group B contains antigen B and the serum has anti-A antibodies. Blood group B has an association with a higher risk of HCV[ 12 ],Transfusion transmitted infections (TTIs) [ 1 12, 16 ], COVID-19 [ 14 ], HCV related HCC [ 15 ], Malaria, Typhoid, Filariasis, Enterotoxoid-Mediated Cholera, Coeliac Disease, Ankylosing Spondylitis Graves disease and non-insulin dependent diabetes are associated with B non-secretors [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Link between human ABO blood groups with diseases influencing blood donors and recipients frequency at RBTC, Delhi, India

Thakur

2023

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Blood groups had associations with many diseases that affect blood transfusion services by increasing or decreasing the blood demand of particular blood group. The present study was designed to compare the frequency of ABO and Rh blood groups among blood donors and blood component recipients. The ABO and Rh(D) blood groups of donors and recipients were determined using Gel card method. The frequency of blood donors and blood component recipients from January 1, 2020, to December 31, 2023, at regional blood transfusion centre of Delhi, were compared using χ2 test. The ABO blood group frequencies of blood donors (n=23025) were: A(23.1%), B(37.53%), AB(10.09%), and O(29.29%). The blood issue (n=20255) was significantly (p=0.0000) higher in A(24.96%), B(39.92%), and lower in AB(9.76%) and O(25.37%). The RDP issue (n=7239) was significantly (p=0.0000) higher in A(24.71%), B(39.34%), and AB(11.53%) and lower in O(24.41%). The FFP issue (n=4164) was significantly (p=0.00024) higher in AB (12.3%) and lower in A (22.05%), B(37.32%), and O(28.14%). The difference between the blood donor frequencies of Rh(D)+Ve(95.19%) and Rh(D)-Ve(4.81%) and the blood issued by Rh(D)+Ve(95.06%) and Rh(D)-Ve(4.94%) was statistically not significant(P=0.52).Blood issues were higher in blood group A and B than in O, platelet issues were higher in A, B and AB than in O, and FFP issues were higher in the AB. Non-O blood groups may have a higher frequency of blood transfusions, while O blood groups may have a protective influence against diseases due to their innate immune response.

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“… 43–45 One meta-analysis showed that people with blood group A are more vulnerable to COVID-19 infection and blood group AB is less susceptible to getting infected with SARS-CoV-2, 43 while another meta-analysis observed that both blood groups A and AB are linked to COVID-19 infection and individuals with blood group O are relatively less vulnerable. 44 Therefore, the association between blood group and COVID-19 positivity is still enigmatic.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study

et al. 2022

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ObjectiveTo identify factors associated with COVID-19 positivity among staff and their family members of icddr,b, a health research institute located in Bangladesh.SettingDhaka, Bangladesh.ParticipantsA total of 4295 symptomatic people were tested for SARS-CoV-2 by reverse-transcription PCR between 19 March 2020 and 15 April 2021. Multivariable logistic regression was done to identify the factors associated with COVID-19 positivity by contrasting test positives with test negatives.ResultForty-three per cent of the participants were tested positive for SARS-CoV-2. The median age was high in positive cases (37 years vs 34 years). Among the positive cases, 97% were recovered, 2.1% had reinfections, 24 died and 41 were active cases as of 15 April 2021. Multivariable regression analysis showed that age more than 60 years (adjusted OR (aOR)=2.1, 95% CI 1.3 to 3.3; p<0.05), blood group AB (aOR=1.5, 95% CI 1.1 to 2; p<0.05), fever (aOR=3.1, 95% CI 2.6 to 3.7; p<0.05), cough (aOR=1.3, 95% CI 1.1 to 1.6; p<0.05) and anosmia (aOR=2.7, 95% CI 1.3 to 5.7; p<0.05) were significantly associated with higher odds of being COVID-19 positive when compared with participants who were tested negative.ConclusionsThe study findings suggest that older age, fever, cough and anosmia were associated with COVID-19 among the study participants.

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ABO blood group influence COVID-19 infection: a meta-analysis

Cited by 11 publications

References 27 publications

Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors in the Western Region of Saudi Arabia: A 7-Year Retrospective Analysis

Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors in the Western Region of Saudi Arabia: A 7-Year Retrospective Analysis

Link between human ABO blood groups with diseases influencing blood donors and recipients frequency at RBTC, Delhi, India

COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study

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