ABO blood group discrepancies among blood donors in Regional Blood Transfusion Centre GTB Hospital, Delhi, India

Sharma, Tanya; Garg, Neeraj; Singh, Bharat

doi:10.1016/j.transci.2013.11.002

Cited by 26 publications

(33 citation statements)

References 8 publications

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“…In the studies by Rahgozar et al, Kim MH et al and Sharma et al, weaker expression of ABO antigens was the second most common cause for ABO discrepancies. 6,8,9 Finding out weaker sub groups can be tricky and time consuming but worth the effort as one of our present cases was a prospective donor for liver transplant. With the diminutive organ donation pool, surgeons are now looking out for ABO incompatible solid organ transplants and weaker subgroups have a reduced chance of acute rejection.…”

Section: Discussionmentioning

confidence: 93%

“…Sharma et al observed that 10% of ABO discrepancies were due to the presence of alloantibodies while Heo et al in his study, found that cold antibodies were the common cause for ABO discrepancies. 9,10 Cold agglutinins are notorious as they give agglutination with all antisera at room temperatures and new technicians tend to label the sample as AB positive when they do not perform reverse grouping. Unless tests are repeated at 37ºC, resolution is difficult and hemolytic transfusion reactions are a definite risk when cold agglutinins are overlooked.…”

Section: Discussionmentioning

confidence: 99%

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Resolving ABO discrepancies by serological workup-an analysis of few cases

Arumugam

Hamsavardhini

Ravishankar³

2017

Int J Res Med Sci

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Background: ABO discrepancies occur whenever the results of red cell grouping and serum grouping are in disagreement. The reasons for discrepancies both clinical and technical have to be sorted out. Further analysis is essential to resolve such discrepancies. If discrepancies are encountered, the interpretation of the ABO grouping has to be delayed until the same has been resolved. The aim of the study was to resolve ABO discrepancies encountered, by serological work up.Methods: All cases of discrepant samples received between August 2014 and May 2016 at the Department of Transfusion Medicine, The Tamilnadu Dr. MGR Medical University, Chennai, India were analyzed to determine the etiology by serological workup.Results: A total of twenty-one samples were analyzed and resolved. Fifteen cases of Type IV discrepancy, two cases of Type II discrepancy, one case Type III discrepancy, one case Type I discrepancy and two cases of technical errors were identified.Conclusions: ABO discrepancies can be resolved serologically if properly worked up. As ABO blood grouping is indispensible in blood transfusion service, it is imperative to resolve such discrepancies before transfusion.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Resolving ABO discrepancies by serological workup-an analysis of few cases

Arumugam

Hamsavardhini

Ravishankar³

2017

Int J Res Med Sci

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“…An ABO typing discrepancy is described as the mismatch between the forward and reverse grouping. Clerical errors, procedural problems and red cell and/or serum‐related problems (Chiaroni et al, ; Kaur et al, ; Sharma et al, ) may cause ABO typing discrepancies, which should be resolved to minimise the likelihood of ABO‐incompatible blood transfusion. The incidence of ABO typing discrepancies in patients is 0·1% (Makroo et al, ).…”

Section: Discussionmentioning

confidence: 99%

A novel Bruton tyrosine kinase gene variation was found in an adult with X‐linked agammaglobulinemia during blood cross‐matching prior to surgical operation

Wang

Tian

Jia

et al. 2019

Transfusion Medicine

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SUMMARY Aims/Objectives To investigate the underlying molecular mechanism of the patient's ABO typing discrepancy. Background ABO typing discrepancy was frequently seen in patients due to different causes. In this study, ABO typing discrepancy was found in a 24‐year‐old man with arthralgia, whose forward ABO grouping was O and reverse ABO grouping was AB. Primary immunodeficiency disease was speculated in this patient, especially X‐linked agammaglobulinemia (XLA). Methods Immunoglobulins of all isotypes were detected using a specific protein analyser. Lymphocyte subgroups were analysed by flow cytometry. All 19 exons and boundaries of BTK gene were amplified by polymerase chain reaction (PCR), and all PCR products were sequenced by a DNA analyser. BTK protein in the leukocytes and platelets was detected by Western blot. Results No B lymphocytes could be detected in the peripheral blood of the patient. A novel BTK gene variation, c.817G>T, in the exon 9 of BTK gene was discovered. No BTK protein expression could be detected in the leukocytes and platelets of the patient. Conclusions XLA could be occasionally discovered by ABO typing discrepancy in some cases because of the deficiency of reciprocal IgM anti‐A and/or anti‐B antibodies in the serum of the patient. Humoral immunodeficiency is one of the causes of ABO typing discrepancy.

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“…The blood group antigens present on red cell membrane are either sugar or proteins and they determine an individual's blood group. Correct identification of blood group of an individual is of utmost importance as errors can lead to fatal transfusion reactions [2]. A discrepancy in blood group exists when reactions in forward typing fail to match with the reverse typing or when there is no concordance between the previous and the current results [2].…”

Section: Introductionmentioning

confidence: 99%

“…Correct identification of blood group of an individual is of utmost importance as errors can lead to fatal transfusion reactions [2]. A discrepancy in blood group exists when reactions in forward typing fail to match with the reverse typing or when there is no concordance between the previous and the current results [2]. It is essential that all ABO group discrepancies are resolved through detailed blood typing for proper identification of a person's blood group [3].…”

Section: Introductionmentioning

confidence: 99%