Abnormally wide confidence intervals in logistic regression: interpretation of statistical program results

Irala, Jokin de; Navajas, Rafael Fernández-Crehuet; Castillo, Amparo Serrano Del

doi:10.1590/s1020-49891997001000007

Cited by 28 publications

(19 citation statements)

References 5 publications

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“…We excluded FNA cytology in our logistic regression model evaluating the impact of nodule and patient factors on risk of malignancy because FNA cytology had a false negative rate of 0% in our study. Consequently, an OR could not be calculated for the logistic regression due to “complete separation” of patients with malignancy from those with benign pathology based on FNA cytology [24]. …”

Section: Discussionmentioning

confidence: 99%

Risk of Malignancy in Thyroid Nodules 4 cm or Larger

Megwalu

2017

Endocrinol Metab

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BackgroundSeveral authors have questioned the accuracy of fine-needle aspiration cytology (FNAC) in large nodules. Some surgeons recommend thyroidectomy for nodules ≥4 cm even in the setting of benign FNAC, due to increased risk of malignancy and increased false negative rates in large thyroid nodules. The goal of our study was to evaluate if thyroid nodule size is associated with risk of malignancy, and to evaluate the false negative rate of FNAC for thyroid nodules ≥4 cm in our patient population.MethodsThis is a retrospective study of 85 patients with 101 thyroid nodules, who underwent thyroidectomy for thyroid nodules measuring ≥4 cm.ResultsThe overall risk of malignancy in nodules ≥4 cm was 9.9%. Nodule size was not associated with risk of malignancy (odds ratio, 1.02) after adjusting for nodule consistency, age, and sex (P=0.6). The false negative rate for FNAC was 0%.ConclusionNodule size was not associated with risk of malignancy in nodules ≥4 cm in our patient population. FNAC had a false negative rate of 0. Patients with thyroid nodules ≥4 cm and benign cytology should not automatically undergo thyroidectomy.

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Section: Discussionmentioning

confidence: 99%

Risk of Malignancy in Thyroid Nodules 4 cm or Larger

Megwalu

2017

Endocrinol Metab

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“…The large confidence intervals may be explained by a low number of patients in this sub-category. Another reason could be multicolinearity [13]. Multicolinearity was, however, ruled out.…”

Section: Discussionmentioning

confidence: 99%

Suicidality in Schizophrenia Spectrum Disorders: The Relationship to Hallucinations and Persecutory Delusions

et al. 2015

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“…As there is no point in estimating the odds ratio for a variable with a frequency equal to zero, statistical programs fail; neither convergence nor correct results are obtained (de Irala, Navajas, & del Castillo, 1997). As a result, MMORPG playing was dropped and the analysis was re-run.…”

Section: Online Gamblingmentioning

confidence: 99%

Gambling and Video Game Playing Among Youth

McBride

Derevensky

2017

JGI

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Gambling and video game playing represent two leisure activities in which adolescents and young adults participate. There are psychological and behavioural parallels between slot machine gambling and video arcade game playing. Because both activities have similar negative effects associated with excessive play (e.g., poor academic performance, moodiness, loss of interest in activities previously enjoyed, interpersonal conflict) there is concern that children and adolescents who are attracted to video games, for both psychological rewards and the challenge, may be at greater risk to gamble. The current research examined the gambling (land-based, online for money, and free online gambling games), video game, and Massively Multiplayer Online Role-Playing Games (MMORPG) playing behaviour in adolescents and young adults to determine shared risk factors and negative consequences for excessive play. These factors include depression, personality characteristics (i.e., impulsivity and extraversion), and outcome expectancies.Results indicate that gamblers, relative to non-gamblers, were more likely to play video games. Video game players were more likely than non-players to gamble offline and report playing free online gambling games. Problem gamblers had higher rates of video game playing than non-gamblers and addicted gamers had higher rates of land-based gambling than nongamers. In addition, MMORPG players, relative to non-players, were more likely to have participated in online gambling activities, gambled offline, and played free online gambling games. There were no significant differences among the three gambling groups for depression, however addicted gamers had significantly higher depression scores than both social and non-

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Abnormally wide confidence intervals in logistic regression: interpretation of statistical program results

Abstract: This study describes the behavior of eight statistical programs (BMDP, EGRET, JMP, SAS, SPSS, STATA, STATISTIX and SYSTAT)

Cited by 28 publications

References 5 publications

Risk of Malignancy in Thyroid Nodules 4 cm or Larger

Risk of Malignancy in Thyroid Nodules 4 cm or Larger

Suicidality in Schizophrenia Spectrum Disorders: The Relationship to Hallucinations and Persecutory Delusions

Gambling and Video Game Playing Among Youth

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