Abnormally high prevalence of major components of the metabolic syndrome in subjects with early-onset idiopathic venous thromboembolism

Minno, M.N.D. Di; Tufano, Antonella; Guida, Anna; Capua, Mirko Di; Gregorio, A.M. De; Cerbone, Anna Maria; Tarantino, Giovanni; Minno, Giovanni Di

doi:10.1016/j.thromres.2010.12.005

Cited by 37 publications

(32 citation statements)

References 42 publications

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“…In 2006, Ageno et al [34] first reported an association between the metabolic syndrome and DVT, the risk of DVT being almost twice as high in subjects with the metabolic syndrome as compared to those without. This association is further confirmed by the results of subsequent case-control studies [35,36], and partially [37,38]. In accordance with this, in a case-control study on 138 subjects with a recent idiopathic VTE, nonalcoholic fatty liver, a clinical condition often found in subjects with the metabolic syndrome [39], significantly and independently predicts the development of idiopathic VTE (OR: 1.9; 95% CI: 1.05-3.8; p \ 0.0001) [40].…”

Section: Association Between Arterial and Venous Thrombotic Events: Csupporting

confidence: 59%

Identifying high-risk individuals for cardiovascular disease: similarities between venous and arterial thrombosis in perspective. A 2011 update

et al. 2011

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The aim of this narrative review is to assess the potential association between arterial and venous thrombotic events. Several studies have suggested that the major cardiovascular risk factors, alone or in combination (e.g. in the metabolic syndrome), are significantly associated with venous thromboembolism (VTE). Recent evidence also suggests that microalbuminuria and non-alcoholic liver steatosis, both markers of arterial disease, may independently predict the risk for VTE. An association between a history of VTE and the risk of future arterial events is also well documented, inflammation and endothelial dysfunction being thought as the common soil on which further investigation in the area should be pursued. The existence of a common pathophysiologic background is also suggested by the evidence that aspirin, low-molecular weight heparin (LMWH) and warfarin are recommended for the prevention and treatment of both venous and arterial thrombosis. In addition, rosuvastatin recently has been shown to prevent venous thromboembolism (VTE) in a time-dependent fashion. Together, these data argue for patients with a history of VTE as being at intermediate/high cardiovascular risk, a concept that implies that VTE patients should undergo a careful assessment for the presence of cardiovascular risk factors and adequate lifestyle changes. The value of routine screening for asymptomatic atherosclerosis (e.g. 2D echocardiography, microalbuminuria, arterial vessel ultrasonography) in these patients should be confirmed in future studies.

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Section: Association Between Arterial and Venous Thrombotic Events: Csupporting

confidence: 59%

Identifying high-risk individuals for cardiovascular disease: similarities between venous and arterial thrombosis in perspective. A 2011 update

et al. 2011

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“…Before surgery (T0), information about age, gender, BMI, hypertension, impaired fasting glucose, hypercholesterolemia, hypertriglyceridemia and previous and/or current treatments were collected according to NCEP criteria [13]. In addition, in each patient a venous blood sample was drawn from the antecubital vein at 8.30e9.00 a.m. after 12e15 h of overnight fasting in order to assess lipid profile status (Total Cholesterol, High-Density-Lipoprotein cholesterol [HDLc], Low-Density-Lipoprotein cholesterol [LDLc], Triglycerides) and glycemic profile (Glycemia, Glycated hemoglobin [HbA1C]).…”

Section: Methodsmentioning

confidence: 99%

Lipid profile changes in patients undergoing bariatric surgery: A comparative study between sleeve gastrectomy and mini-gastric bypass

Milone

Lupoli

Maietta

et al. 2015

International Journal of Surgery

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“…Compared with individuals without MS, individuals having MS have higher levels of fibrinogen and factor VIII activity, thereby having a 2.2 times more likelihood to develop VTE [9]. Both MS as a whole and its major individual determinants confer an increased risk for VTE [10]. In this retrospective study, we investigated the association between MS and postoperative deep vein thrombosis (DVT) among patients undergoing TJA.…”

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confidence: 99%

Metabolic Syndrome and Deep Vein Thrombosis After Total Knee and Hip Arthroplasty

Song

Rong

Yao

et al. 2016

The Journal of Arthroplasty

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Abnormally high prevalence of major components of the metabolic syndrome in subjects with early-onset idiopathic venous thromboembolism

Cited by 37 publications

References 42 publications

Identifying high-risk individuals for cardiovascular disease: similarities between venous and arterial thrombosis in perspective. A 2011 update

Identifying high-risk individuals for cardiovascular disease: similarities between venous and arterial thrombosis in perspective. A 2011 update

Lipid profile changes in patients undergoing bariatric surgery: A comparative study between sleeve gastrectomy and mini-gastric bypass

Metabolic Syndrome and Deep Vein Thrombosis After Total Knee and Hip Arthroplasty

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