Abstract:Abstract-The delayed type hypersensitivity (DTH) response of spontaneously hypertensive rats (SHR) was compared with that of Wistar Kyoto rats (WKY), a normotensive strain.SHR showed a lower DTH response to Bordetella pertussis than WKY, especially 48 to 72 hr after antigenic challenge.These results were observed before appearance of abnormality of antibody formation or blood pressure. The reduced DTH responses of SHR were partially restored by either transfer of WKY thymocytes or treatment with levamisole.Con… Show more
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