Abnormality of subcortical volume and resting functional connectivity in adolescents with early-onset and prodromal schizophrenia

Wen, Dan; Wang, Junjie; Yao, Guanqun; Li, Sha; Li, Xinrong; Li, Jing; Li, Hong; Xu, Yong

doi:10.1016/j.jpsychires.2021.05.052

Cited by 13 publications

(14 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hippocampus may play a key role in cognitive impairment and improvement of cognition due to its critical role in memory and learning. The present study found significantly reduced hippocampus volumes in FES consistent with most similar studies on Sch ( 19 , 20 ); notably, it was demonstrated that hippocampal volume deficits were more severe in samples with a higher proportion of unmedicated patients in the large sample from the ENIGMA work team ( 11 ), indicating that reduced hippocampal volumes were not moderated by the duration of illness or medicine. In our next correlation analysis and hierarchical regression analysis, the relationship between hippocampus volumes and cognitive performance was shown.…”

Section: Discussionsupporting

confidence: 91%

Subcortical Brain Volumes Relate to Neurocognition in First-Episode Schizophrenia, Bipolar Disorder, Major Depression Disorder, and Healthy Controls

et al. 2022

View full text Add to dashboard Cite

ObjectiveTo explore differences and similarities in relationships between subcortical structure volumes and neurocognition among the four subject groups, including first-episode schizophrenia (FES), bipolar disorder (BD), major depression disorder (MDD), and healthy controls (HCs).MethodsWe presented findings from subcortical volumes and neurocognitive analyses of 244 subjects (109 patients with FES; 63 patients with BD, 30 patients with MDD, and 42 HCs). Using the FreeSurfer software, volumes of 16 selected subcortical structures were automatically segmented and analyzed for relationships with results from seven neurocognitive tests from the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) Cognitive Consensus Battery (MCCB).ResultsLarger left lateral ventricle volumes in FES and BD, reduced bilateral hippocampus and amygdala volumes in FES, and lower bilateral amygdala volumes in BD and MDD were presented compared with HCs, and both FES and BD had a lower bilateral amygdala volume than MDD; there were seven cognitive dimension, five cognitive dimension, and two cognitive dimension impairments in FES, BD, and MDD, respectively; significant relationships were found between subcortical volumes and neurocognition in FES and BD but not in MDD and HCs; besides age and years of education, some subcortical volumes can predict neurocognitive performances variance.ConclusionThe different degrees of subcortical volume lessening may contribute to the differences in cognitive impairment among the three psychiatric disorders.

show abstract

Section: Discussionsupporting

confidence: 91%

Subcortical Brain Volumes Relate to Neurocognition in First-Episode Schizophrenia, Bipolar Disorder, Major Depression Disorder, and Healthy Controls

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Second, regarding GM, our model clearly defined anatomical areas, such as the prefrontal cortex (PFC), hippocampus, amygdala, and septum, some of them in both hemispheres. Numerous studies have demonstrated the relevance of the morphological changes of these areas in mental disorders [41,42] together with the disconnection and lack of symmetry between both cerebral hemispheres [43,44]. Similar volumetric abnormalities have also been reported for the animal model used in this study [24,45].…”

Section: Discussionsupporting

confidence: 79%

A Novel Bayesian Linear Regression Model for the Analysis of Neuroimaging Data

et al. 2022

View full text Add to dashboard Cite

In this paper, we propose a novel Machine Learning Model based on Bayesian Linear Regression intended to deal with the low sample-to-variable ratio typically found in neuroimaging studies and focusing on mental disorders. The proposed model combines feature selection capabilities with a formulation in the dual space which, in turn, enables efficient work with neuroimaging data. Thus, we have tested the proposed algorithm with real MRI data from an animal model of schizophrenia. The results show that our proposal efficiently predicts the diagnosis and, at the same time, detects regions which clearly match brain areas well-known to be related to schizophrenia.

show abstract

“…The baseline characteristics of all participants and the brain regions of gray matter alterations are summarized in Table 1 . Two SCZ studies found GM volume changes without reporting the foci ( 23 , 29 ). Four studies did not find any significant differences in GM volume between patients and healthy controls ( 26 , 33 , 36 , 38 ).…”

Section: Resultsmentioning

confidence: 99%

Gray Matter Alterations in Pediatric Schizophrenia and Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies

et al. 2022

View full text Add to dashboard Cite

ObjectiveThe aim of this study is comparing gray matter alterations in SCZ pediatric patients with those suffering from obsessive-compulsive disorder (OCD) based on a systematic review and an activation likelihood estimation (ALE) meta-analysis.MethodsA systematic literature search was performed in PubMed, Elsevier, and China National Knowledge Infrastructure (CNKI). A systematic review and an ALE meta-analysis were performed to quantitatively examine brain gray matter alterations.ResultsChildren and adolescents with schizophrenia had decreased gray matter volume (GMV) mainly in the prefrontal cortex (PFC), temporal cortex (such as the middle temporal gyrus and transverse temporal gyrus), and insula, while children and adolescents with OCD mainly had increased GMV in the PFC and the striatum (including the lentiform nucleus and caudate nucleus), and decreased GMV in the parietal cortex.ConclusionsOur results suggest that gray matter abnormalities in the PFC may indicate homogeneity between the two diseases. In children and adolescents, structural alterations in schizophrenia mainly involve the fronto-temporal and cortico-insula circuits, whereas those in OCD mainly involve the prefrontal-parietal and the prefrontal-striatal circuits.

show abstract

Abnormality of subcortical volume and resting functional connectivity in adolescents with early-onset and prodromal schizophrenia

Cited by 13 publications

References 51 publications

Subcortical Brain Volumes Relate to Neurocognition in First-Episode Schizophrenia, Bipolar Disorder, Major Depression Disorder, and Healthy Controls

Subcortical Brain Volumes Relate to Neurocognition in First-Episode Schizophrenia, Bipolar Disorder, Major Depression Disorder, and Healthy Controls

A Novel Bayesian Linear Regression Model for the Analysis of Neuroimaging Data

Gray Matter Alterations in Pediatric Schizophrenia and Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies

Contact Info

Product

Resources

About