Abnormality of standing posture improves in patients with bilateral spastic cerebral palsy following lower limb surgery

Buddhdev, Pranai; Fry, Nicola; Lepage, R.; Wiley, Mary Elizabeth; Gough, Martin; Shortland, Adam P

doi:10.1016/j.gaitpost.2017.03.014

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…To date, the clinical methods for treating SCP mainly include functional training, surgical treatment, physical therapy, acupuncture and massage, and drug therapy (Chin et al, 2020). Comparing these methods, surgical treatment is a very efficient method for patients with severe movement disorders (Buddhdev et al, 2017). The key purpose of surgery is to adjust muscle tension and balance muscle force.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Multilevel Surgeries in Children With Spastic Cerebral Palsy Based on Surface Electromyography

Luo

Zhang

et al. 2021

Front. Neurosci.

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The root mean square (RMS) of the surface electromyography (sEMG) signal can respond to neuromuscular function, which displays a positive correlation with muscle force and muscle tension under positive and passive conditions, respectively. The purpose of this study was to investigate the changes in muscle force and tension after multilevel surgical treatments, functional selective posterior rhizotomy (FSPR) and tibial anterior muscle transfer surgery, and evaluate their clinical effect in children with spastic cerebral palsy (SCP) during walking. Children with diplegia (n = 13) and hemiplegia (n = 3) with ages from 4 to 18 years participated in this study. They were requested to walk barefoot at a self-selected speed on a 15-m-long lane. The patient's joints' range of motion (ROM) and sEMG signal of six major muscles were assessed before and after the multilevel surgeries. The gait cycle was divided into seven phases, and muscle activation state can be divided into positive and passive conditions during gait cycle. For each phase, the RMS of the sEMG signal amplitude was calculated and also normalized by a linear envelope (10-ms running RMS window). The muscle tension of the gastrocnemius decreased significantly during the loading response, initial swing, and terminal swing (p < 0.05), which helped the knee joint to get the maximum extension when the heel is on the ground and made the heel land smoothly. The muscle force of the gastrocnemius increased significantly (p < 0.05) during the mid-stance, terminal stance, and pre-swing, which could generate the driving force for the human body to move forward. The muscle tension of the biceps femoris and semitendinosus decreased significantly (p < 0.05) during the terminal stance, pre-swing, and initial swing. The decreased muscle tension could relieve the burden of the knee flexion when the knee joint was passively flexed. At the terminal swing, the muscle force of the tibial anterior increased significantly (p < 0.05), which could improve the ankle dorsiflexion ability and prevent foot drop and push forward. Thus, the neuromuscular function of cerebral palsy during walking can be evaluated by the muscle activation state and the RMS of the sEMG signal, which showed that multilevel surgical treatments are feasible and effective to treat SCP.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Multilevel Surgeries in Children With Spastic Cerebral Palsy Based on Surface Electromyography

Luo

Zhang

et al. 2021

Front. Neurosci.

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“…1 The immediate consequences of SCI are motor and sensory deficits with spasticity, such as initiate and coordinate muscle spasticity. 2 Muscle spasticity can lead to uncontrolled body movements, 3 sustained abnormal postures of the affected body part 4 and even muscle damage and rhabdomyolysis sometimes. 5 Muscle spasticity is usually caused by neuromuscular excitability 6 and represents a complicated array of neurological motor disorders.…”

Section: Introductionmentioning

confidence: 99%

<p>Botulinum Toxin Type A Possibly Affects Ca<sub>v</sub>3.2 Calcium Channel Subunit in Rats with Spinal Cord Injury-Induced Muscle Spasticity</p>

Zhu

Zhang

et al. 2020

DDDT

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Introduction: Spinal cord injury (SCI) often causes muscle spasticity, which can be inhibited by using calcium channel blocker. Botulinum toxin type A (BoT-A) shows therapeutic efficacy on spasticity and may exert inhibitory effects on the calcium channel. Methods: A rat model with muscle spasticity was established after SCI via contusion and compression. Different concentrations (0, 1, 3 and 6 U/kg) of BoT-A Botox were injected in the extensor digitorum longus (EDL) muscles of the right hindlimb in the muscle spasticity model. The changes of muscle spasticity and calcium level in EDL muscles were measured after the establishment of SCI-induced spasticity. Ca v 3.2 calcium channel subunit and its mutant (M1560V) were analyzed using Western blot before (input) or after immunoprecipitation with anti-FLAG antibody, and their currents were measured in motoneurons by using whole-cell voltage clamp recordings. Results: SCI induced muscle spasticity, whereas calcium level in EDL muscles and expression of Ca v 3.2 was increased in the SCI model when compared with the sham group (p < 0.05). BoT-A Botox treatment significantly reduced muscle spasticity and calcium level in EDL muscles and Ca v 3.2 expression in a dose-dependent way (p < 0.05). The ratio of biotinylated to total Ca v 3.2 was reduced in the mutant (M1560V) of Ca v 3.2 and lower than that in the wild Ca v 3.2. BoT-A Botox intervention also reduced the current values of calcium channel and the ratio in a dose-dependent way (p < 0.05). Discussion: BoT-A Botox possibly attenuates SCI-induced muscle spasticity by affecting the expression of Ca v 3.2 calcium channel subunit in the rat models. There may be multiple mechanisms for the function of BoT-A Botox. Further work is needed to be done to address these issues.

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Application of microsensors and support vector machines in the assessment of lower limb posture correction in adolescents

Yin-man

Wang²

2022

Concurrency and Computation

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SummaryAutomatic monitoring of physical activity provides reliable data support for the maintenance of people's physical health and provides more scientific data for studying the relationship between physical activity and disease. In this article, a research on the evaluation of adolescent lower limb posture correction based on collaborative filtering and microsensors is carried out. Aiming at the problem that the human body posture monitoring system needs multiple nodes, this article simplifies the existing human body posture monitoring model and establishes a human body model with four degrees of freedom of the lower limbs. On this basis, the micro‐sensor assembly scheme and monitoring node layout scheme for obtaining model description parameters are determined. Methods such as collaborative filtering and support vector machines are used in the process of sensor data processing and correction effect evaluation. Finally, this article uses the constructed human body posture monitoring system to carry out the recognition test of the specific posture of the human body. The experimental results show that the evaluation scheme can effectively monitor and evaluate the effect of lower limb posture correction in adolescents.

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Abnormality of standing posture improves in patients with bilateral spastic cerebral palsy following lower limb surgery

Cited by 3 publications

References 36 publications

Evaluation of Multilevel Surgeries in Children With Spastic Cerebral Palsy Based on Surface Electromyography

Evaluation of Multilevel Surgeries in Children With Spastic Cerebral Palsy Based on Surface Electromyography

<p>Botulinum Toxin Type A Possibly Affects Ca<sub>v</sub>3.2 Calcium Channel Subunit in Rats with Spinal Cord Injury-Induced Muscle Spasticity</p>

Application of microsensors and support vector machines in the assessment of lower limb posture correction in adolescents

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