Abnormality of Estrogen Metabolism in Human Subjects With Myocardial Infarction

Abstract

Estrogen metabolism has been investigated in male subjects with and without previous myocardial infarction. The urinary excretion of estriol, estrone, and estradiol-17β has been measured 1 day before and 4 days after intramuscular injection of estradiol-17β. The excretion of the individual estrogens resulting from the administration of estradiol was determined by subtracting preinjection values from the daily excretion following injection. The resultant values of estriol (T), estrone (O), and estradiol-l7β (D) were expressed as the following ratios:[Formula: see text]These urinary estrogen ratios were found to be significantly higher in subjects with previous myocardial infarction than in control subjects. The ratios in the infarction group were not influenced by bed rest nor by the duration of time following infarction which varied from 1 week to 2 years.

Oestrogen metabolism and excretion in liver disease

“…In the metabolism experiments, the overall recovery of administered oestradiol as urinary oestriol, oestrone, and oestradiol, was usually normal but occasionally low, as reported by St0a et al (1958) and Lyngbye and Mogensen (1961): no high recoveries similar to those reported by Glass et al (1944) were obtained. The ratio of oestriol to other oestrogens recovered was usually higher than normal, indicating an increased conversion, but such a finding is not confined to liver disease and has been reported in other diseases, such as breast cancer and coronary disease (Brown, 1958;Bauld, Givner, and Milne, 1957). Occasionally the ratio of oestradiol to oestrone was increased, as was demonstrated by Lyngbye and Mogensen (1961).…”

Estrogenic Management of Benign Prostatism, Including Early and Poor‐risk Cases: 7‐year Experience*

“…They speculated that the failure to demonstrate neoplastic cells in the first two biopsies may have been due to rapid regeneration of adenomatous tissue resulting from a high level of estriol. Excretion of a significantly greater proportion of the urinary estrogen as estriol has been reported by others in prostatic cancer (87a), coronary disease (87b, c) and liver disease (87d, e). On the other hand, estradiol substantially increases the capacities of plasma cortisol‐binding globulin and thyroxine‐binding globulin, whereas estriol (20–40 mg daily for seven to fourteen days) does not significantly increase these capacities (88).…”

Hormones and neoplasia

“…Minor differences in the form in which oestrogen is excreted have been noted in women with ental tumours established breast cancer or who racially are at risk and prolactin from the disease (Brown, 1958;Marmorston, ,he growth of Crowley, Myers, Stem, and Hopkins, 1965;Macibtless others Mahon et al, 1971). However, these observations are in part unconfirmed and not necessarily specific to cancer of the breast (Bauld, Givner, and Milne, 1957;Hellman, Fishman, Zumoff, Cassouto, and Gallagher, 1967). behaviour of There is also evidence for involvement of the wrs known to pituitary in human breast cancer.…”