Abnormality of Estrogen Metabolism in Human Subjects With Myocardial Infarction

Abstract

Estrogen metabolism has been investigated in male subjects with and without previous myocardial infarction. The urinary excretion of estriol, estrone, and estradiol-17β has been measured 1 day before and 4 days after intramuscular injection of estradiol-17β. The excretion of the individual estrogens resulting from the administration of estradiol was determined by subtracting preinjection values from the daily excretion following injection. The resultant values of estriol (T), estrone (O), and estradiol-l7β (D) were expressed as the following ratios:[Formula: see text]These urinary estrogen ratios were found to be significantly higher in subjects with previous myocardial infarction than in control subjects. The ratios in the infarction group were not influenced by bed rest nor by the duration of time following infarction which varied from 1 week to 2 years.

Excretion of Oestrone and Oestriol in the Urine of Some Male Subjects with the Dubin‐Johnson Syndrome and Liver Cirrhosis Following Oral Administration of Oestradiol Benzoate

“…However, the conjugated oestrogens are better absorbed than the free ones (29) and there is no report in the literature to suggest that orally administered oestradiol benzoate is metabolized in a fundamentally different way from oestradiol. The good agreement of the control values with the results obtained by Brown (8) and by Bauld et al (5) indicate that this substance is metabolized as oestradiol.…”

Estrogenic Management of Benign Prostatism, Including Early and Poor‐risk Cases: 7‐year Experience*

“…They speculated that the failure to demonstrate neoplastic cells in the first two biopsies may have been due to rapid regeneration of adenomatous tissue resulting from a high level of estriol. Excretion of a significantly greater proportion of the urinary estrogen as estriol has been reported by others in prostatic cancer (87a), coronary disease (87b, c) and liver disease (87d, e). On the other hand, estradiol substantially increases the capacities of plasma cortisol‐binding globulin and thyroxine‐binding globulin, whereas estriol (20–40 mg daily for seven to fourteen days) does not significantly increase these capacities (88).…”

Genetic predisposition to carcinoma of the breast: Multiple human genotypes for estrogen 16 alpha hydroxylase activity in caucasians

“…Pregnancy, through augmentation of estriol production from dehydroepiandrosterone sulfate, induces hyperexcretion of estriol from a nonovarian pathway, which may account for the protection against breast cancer risk which it confers among Caucasians (14). Estriol production occurs throughout life, before and after active gonadal function, from nongonadal nonadrenal metabolism of delta-4-androstenedione, which may contribute significantly to estriol quotients during the luteal phase of the menstrual cycle (3) and following menopause, castration, or stress (5). A mutant genotype affecting this pathway would not account for the impairment of conversion of exogenous estradiol 17B to estriol demonstrated by Bacigalupo and Schubert in chronic fibrocystic disease as young as 21 years of age, and in breast cancer in German women, who also concluded that there was a metabolic defect in estrogen oxidation to estriol (2,1966).…”