Abnormalities of the uncinate fasciculus correlate with executive dysfunction in patients with left temporal lobe epilepsy

Diao, Limei; Yu, Haichun; Zheng, Jinou; Chen, Zirong; Huang, Duruo; Yu, Lu

doi:10.1016/j.mri.2015.02.011

Cited by 39 publications

(28 citation statements)

References 34 publications

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“…Full text was screened in 71 cases and reference lists were inspected to detect additional studies not identified with the initial search. Forty-two studies met the inclusion criteria for the meta-analysis (Ahmadi et al, 2009, Andrade et al, 2014, Arfanakis et al, 2002, Braakman et al, 2014, Campos et al, 2015, Concha et al, 2005, Concha et al, 2007, Concha et al, 2009, Deppe et al, 2008, Diao et al, 2015, Diehl et al, 2008, Duning et al, 2010, Gao et al, 2012, Govindan et al, 2008, Gross et al, 2006, Holt et al, 2011, Hutchinson et al, 2010, Keller et al, 2011, Keller et al, 2012, Kemmotsu et al, 2011, Kemmotsu et al, 2014, Kim et al, 2011, Knake et al, 2009, Kori et al, 2013, Labate et al, 2015, Lee et al, 2013, Lee et al, 2014, Li et al, 2010, Liacu et al, 2012, Lin et al, 2008, Liu et al, 2011, Mao et al, 2011, McDonald et al, 2008, Meng et al, 2010a, Nilsson et al, 2008, Powell et al, 2007, Pustina et al, 2015, Rodrigo et al, 2007, Scanlon et al, 2013, Vulliemoz et al, 2011, Wang et al, 2010, Xiao et al, 2014). The total number of people with epilepsy and controls was 1027 and 1122, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Previous papers have linked results from cognitive tests across distinct domains with white matter modifications (Diao et al, 2015, McDonald et al, 2008, Riley et al, 2010). For instance, diffusivity changes in the uncinate fasciculus and inferior fronto-occipital fasciculus correlated with commonly reported cognitive comorbidities such as impaired memory and altered executive functioning (McDonald et al, 2008, Riley et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Slinger

Sinke

Braun

et al. 2016

NeuroImage: Clinical

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ObjectiveSince the introduction of diffusion tensor imaging, white matter abnormalities in epilepsy have been studied extensively. However, the affected areas reported, the extent of abnormalities and the association with relevant clinical parameters are highly variable. We aimed to obtain a more consistent estimate of white matter abnormalities and their association with clinical parameters in different epilepsy types.MethodsWe systematically searched for differences in white matter fractional anisotropy and mean diffusivity, at regional and voxel level, between people with epilepsy and healthy controls. Meta-analyses were used to quantify the directionality and extent of these differences. Correlations between white matter differences and age of epilepsy onset, duration of epilepsy and sex were assessed with meta-regressions.ResultsForty-two studies, with 1027 people with epilepsy and 1122 controls, were included with regional data. Sixteen voxel-based studies were also included. People with temporal or frontal lobe epilepsy had significantly decreased fractional anisotropy (Δ –0.021, 95% confidence interval –0.026 to –0.016) and increased mean diffusivity (Δ0.026 × 10–3 mm2/s, 0.012 to 0.039) in the commissural, association and projection white matter fibers. White matter was much less affected in generalized epilepsy. White matter changes in people with focal epilepsy correlated with age at onset, epilepsy duration and sex.SignificanceThis study provides a better estimation of white matter changes in different epilepsies. Effects are particularly found in people with focal epilepsy. Correlations with the duration of focal epilepsy support the hypothesis that these changes are, at least partly, a consequence of seizures and may warrant early surgery. Future studies need to guarantee adequate group sizes, as white matter differences in epilepsy are small.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Slinger

Sinke

Braun

et al. 2016

NeuroImage: Clinical

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“…Both UF and IFOF are crucial association tracts for the ventral intra-hemispheric transfer of information between frontal and occipital, temporal and parietal cortices ( Hau et al, 2016 ). Deficit of WM microstructural integrity on left UF has been associated with worse executive function in individuals with temporal lobe epilepsy ( Diao et al, 2015 ). However, the relationship in an ageing population has not been previously reported.…”

Section: Discussionmentioning

confidence: 99%

The association of regional white matter lesions with cognition in a community-based cohort of older individuals

Jiang

Paradise

Liu

et al. 2018

NeuroImage: Clinical

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Emerging evidence from lesion-symptom mapping (LSM) studies suggested that regional white matter lesions (WML) on strategic white matter (WM) fiber tracts are significantly associated with specific cognitive domains, independent of global WML burden. However, previous LSM investigations were mostly carried out in disease cohorts, with little evidence from community-based older individuals, making findings difficult to generalize. Moreover, most LSM studies applied a threshold to the probabilistic atlas, leading to the loss of information and threshold-dependent findings. Furthermore, it is still unclear whether associations between regional WML and cognition are independent of global grey matter (GM) and WM volumes, which have also been linked to cognition. In the current study, we undertook a region of interest (ROI) LSM study to examine the relationship between regional WML on strategic WM tracts and cognitive performance in a large community-based cohort of older individuals (N = 461; 70–90 years). WML were extracted using a publicly available pipeline, UBO Detector (https://cheba.unsw.edu.au/group/neuroimaging-pipeline). Mapping of WML to the WM atlas was undertaken using an automated TOolbox for Probabilistic MApping of Lesions (TOPMAL), which we introduce here, and is implemented in UBO Detector. The results show that different patterns of brain structural volumes in the ageing brain were associated with different cognitive domains. Regional WML were associated with processing speed, executive function, and global cognition, independent of total GM, WM and WML volumes. Moreover, regional WML explained more variance in executive function, compared to total GM, WM and WML volumes. The current study highlights the importance of studying regional WML in age-related cognitive decline.

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“…However, ictal and interictal discharges have been considered the main cause of cognitive deficits in patients with epilepsy [14] . Moreover, neuroimaging studies have also documented functional and morphological brain abnormalities in patients affected by epilepsy, including gray matter atrophy, glucose hypometabolism in several brain areas, and abnormal white matter integrity, suggesting structural causes for cognitive dysfunctions [6] , [15] , [16] , [17] . Therefore, interventions aimed at preserving or restoring cognition in patients with epilepsy are actually invited, since cognitive impairment appears to be progressive and increases the risk of dementia [18] .…”

Section: Discussionmentioning

confidence: 99%

Lacosamide may improve cognition in patients with focal epilepsy: EpiTrack to compare cognitive side effects of lacosamide and carbamazepine

Liguori

Izzi

Manfredi

et al. 2018

Epilepsy & Behavior Case Reports

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Carbamazepine (CBZ) is a first generation anti-seizure drug, considered as first choice therapy in focal epilepsy but associated with cognitive side effects. Lacosamide (LCM) is a third-generation anti-seizure drug approved for treating focal epilepsy. This case series documented the comparable efficacy of LCM and CBZ as first add on treatments in patients affected by uncontrolled focal seizures. LCM showed an increase in EpiTrack scores, which measure cognitive abilities, at follow-up compared to CBZ. This preliminary data may represent the basis for future prospective studies aimed at comparing the long-term cognitive side effects of LCM and CBZ.

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Abnormalities of the uncinate fasciculus correlate with executive dysfunction in patients with left temporal lobe epilepsy

Cited by 39 publications

References 34 publications

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

The association of regional white matter lesions with cognition in a community-based cohort of older individuals

Lacosamide may improve cognition in patients with focal epilepsy: EpiTrack to compare cognitive side effects of lacosamide and carbamazepine

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