Abnormalities of the muscles of the soft palate and their impact on auditory function in patients operated on for cleft palate: a case-control study

D, Arunachalam; Pendem, Sneha; Ravi, Poornima

doi:10.1016/j.bjoms.2019.05.007

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…However, very few studies have analyzed this association in a side-specific manner. To our knowledge, there has been only one previous side-specific study on ETD in patients with cleft palate, and that study demonstrated that the TVP fails to open the Eustachian tube more often on the cleft side than the noncleft side (Arunachalam et al, 2019). We looked at 74 children with UCLP and found that post-tube hearing loss and complications (retractions, perforations, and cholesteatomas) were significantly more prevalent on the cleft side than the noncleft side.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the purpose of this study was to evaluate whether children with UCLP have more otologic problems indicative of prolonged ETD on their cleft or noncleft side. To date, there has been only one other side-specific study done on patients with CLP, and it involved adults (Arunachalam et al, 2019). Our study is the first to explore ETD in children with UCLP in a side-specific manner.…”

Section: Introductionmentioning

confidence: 99%

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Eustachian Tube Dysfunction in Children With Unilateral Cleft Lip and Palate: Differences Between Ipsilateral and Contralateral Ears

Shaffer

Jabbour

2019

The Cleft Palate Craniofacial Journal

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Objective: To evaluate Eustachian tube dysfunction in the ipsilateral and contralateral ears, in children with unilateral cleft lip and palate (UCLP). Design: Retrospective chart review. Setting: Tertiary care children’s hospital. Patients: Seventy-four consecutive patients with UCLP born between 2005 and 2011 and treated at UPMC Children’s Hospital of Pittsburgh Cleft-Craniofacial Center were included. Main Outcome Measures: Conductive hearing loss, tympanogram type, number of middle ear effusions, tympanostomy tubes, and complications. Hypothesis was formulated prior to data collection. Results: Conductive hearing loss was nearly twice as common in the ipsilateral ear (43.2%) compared with contralateral (23.0%; P = .001, McNemar test). There were no significant differences in the frequency of each type of tympanogram between the contralateral and ipsilateral ears. The proportions of ipsilateral (90.5%) and contralateral (91.9%) ears with effusion were not significantly different. The total number of tubes received was not significantly different between the 2 ears (median of 2 bilaterally). When combined, complications (retractions, perforations, and cholesteatomas) were significantly more common in the ipsilateral ear (29.7%) compared with the contralateral ear (18.9%; P = .039, McNemar test). Conclusion: In children with UCLP, there were significantly more instances of conductive hearing loss and complications on the cleft side compared to the noncleft side. This suggests that Eustachian tube dysfunction may indeed be more severe on the cleft side. Considering this information, clinicians may need to be especially observant of the ipsilateral ear.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eustachian Tube Dysfunction in Children With Unilateral Cleft Lip and Palate: Differences Between Ipsilateral and Contralateral Ears

Shaffer

Jabbour

2019

The Cleft Palate Craniofacial Journal

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“…Muscles of the craniofacial region are of great importance for function and esthetic appearance. 56,57 These muscles may be subject to trauma, cancer, generalized muscle disorders, surgical resections, or autoimmune diseases necessitating grafting/regenerative procedures. Orofacial congenital defects, such as cleft lip and/or palate, are associated with impaired muscle regeneration and fibrosis after surgery also requiring repair.…”

Section: Craniofacial Skeletal Muscle Regenerationmentioning

confidence: 99%

Recent update on craniofacial tissue engineering

Emara

Shah²

2021

J Tissue Eng

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The craniofacial region consists of several different tissue types. These tissues are quite commonly affected by traumatic/pathologic tissue loss which has so far been traditionally treated by grafting procedures. With the complications and drawbacks of grafting procedures, the emerging field of regenerative medicine has proved potential. Tissue engineering advancements and the application in the craniofacial region is quickly gaining momentum although most research is still at early in vitro/in vivo stages. We aim to provide an overview on where research stands now in tissue engineering of craniofacial tissue; namely bone, cartilage muscle, skin, periodontal ligament, and mucosa. Abstracts and full-text English articles discussing techniques used for tissue engineering/regeneration of these tissue types were summarized in this article. The future perspectives and how current technological advancements and different material applications are enhancing tissue engineering procedures are also highlighted. Clinically, patients with craniofacial defects need hybrid reconstruction techniques to overcome the complexity of these defects. Cost-effectiveness and cost-efficiency are also required in such defects. The results of the studies covered in this review confirm the potential of craniofacial tissue engineering strategies as an alternative to avoid the problems of currently employed techniques. Furthermore, 3D printing advances may allow for fabrication of patient-specific tissue engineered constructs which should improve post-operative esthetic results of reconstruction. There are on the other hand still many challenges that clearly require further research in order to catch up with engineering of other parts of the human body.

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“…Cleft palate (CP) is a common congenital anomaly in which the anatomy of the muscles of the soft palate is disrupted, leading to eustachian tube dysfunction (ETD). Subsequently, inadequate drainage and infection of middle ear secretions results in middle ear disease in these children (Karanth & Whittemore, 2018;Arunachalam et al, 2019). Otitis media with effusion (OME) in children with CP is nearly universal, with a reported incidence as high as 97% (Dhillon, 1988;Grant et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

Subannular Tubes in Children With Cleft Palate

Martins

Alexandre

Santos

et al. 2021

The Cleft Palate Craniofacial Journal

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Objective: To investigate subannular tube (SAT) placement as an alternative treatment of chronic middle ear disease in children with cleft palate. Design: Retrospective cohort study. Participants: All children with cleft palate with intractable otitis media with effusion and/or with tympanic membrane retraction, operated for insertion of 1 or more sets of transtympanic tubes followed by SAT in a tertiary center. Main Outcome Measures: Audiological outcomes, average duration of tubes, and postoperative complications were analyzed. Results: This study included 21 children with cleft palate, aged 3 to 14 years. A total of 38 ears was evaluated. The median time of follow-up was 42 months. During follow-up, 69.2% of the patients had no complications. Observed complications were otorrhea (13.5%) and tube obstruction (7.7%). In 7.9% of the cases, otitis media with effusion relapsed after tube extrusion. By the end of the study, 76.3% of the tubes remained in situ and 68.4% of the tympanic membranes had the SAT in place and had no significant alterations. The mean duration of SATs was 16 months, which was significantly superior to transtympanic tube duration. A significant sustained improvement in the hearing of children with SATs was observed. Conclusion: Subannular tube insertion results in hearing improvement to normal range and tympanic retraction pockets reversion in children with cleft palate with persistent otitis media with effusion and tympanic retraction/atelectasis. This surgery appears to be safe and provides long-term efficient middle ear aeration. Strict postoperative follow-up is crucial for the success of the treatment.

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Abnormalities of the muscles of the soft palate and their impact on auditory function in patients operated on for cleft palate: a case-control study

Cited by 5 publications

References 24 publications

Eustachian Tube Dysfunction in Children With Unilateral Cleft Lip and Palate: Differences Between Ipsilateral and Contralateral Ears

Eustachian Tube Dysfunction in Children With Unilateral Cleft Lip and Palate: Differences Between Ipsilateral and Contralateral Ears

Recent update on craniofacial tissue engineering

Subannular Tubes in Children With Cleft Palate

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