Abnormalities of parietal and prerolandic somatosensory evoked potentials in Huntington's disease

Early Huntington’s disease affects movements in transformed sensorimotor mappings

“…HD patients can show abnormal somatosensory processing (Abbruzzese, Dall'Agata, Morena, Reni, & Favale, 1990;Boecker et al, 1999;Kuwert et al, 1993;Topper, Schwarz, Podoll, Domges, & Noth, 1993). However, in patients with somatosensory deafferentation, impaired proprioception can actually facilitate mirror-inverted movements (Lajoie et al, 1992).…”

Cortical and striatal neurone number in Huntington's disease

“…These observations favour additional mechanisms of cortical neuronal death besides retrograde degeneration. In addition, electrophysiological observations in early stages of Huntington's disease suggest an early affliction of primary somatosensory fields [1,34,62,87,117]. Josiassen et al [67] described visual as well as auditory deficits in asymptomatic offsprings of Huntington's disease patients.…”

“…These stages exhibit slight or absent striatal degeneration in post-mortem [86] and NMR studies [44]. Therefore, we interpret the marked laminar nerve cell loss in areas [1][2][3]17, and 41 as terminal stages of an early-onset cortical neuronal degeneration.…”

Different contribution of joint and cutaneous inputs to early scalp somatosensory evoked potentials

“…The physiological meaning of the frontal N30 somatosensory evoked potential (SEP) is still a matter of debate. [1][2][3]5,8,10,17,32,43,44,46,51 Indirect elements for solving this problem might be found by analyzing the modifications of the N30 component that occur in response to different physiological stimuli. Cortical SEPs can be elicited by stimulation of cutaneous as well as proprioceptive afferents.…”