Abnormalities of Insulin Secretion and β‐Cell Defects in Type 2 Diabetes

Alsahli, Mazen; Gerich, John E.

doi:10.1002/9781444324808.ch10

Cited by 9 publications

(7 citation statements)

References 168 publications

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“…IJBR (2015) 6 (10) www.ssjournals.com controls is in agreement with the report that this ion plays important role in insulin secretion [21], and that insulin level must be decreased in diabetics [22]. HbA1c was established as the gold standard of glycemic control.…”

Section: Discussionsupporting

confidence: 71%

Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin

Akpovi

Segbo

Marc

et al. 2015

Int Jour of Biomed Res

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Background: Abnormal lipid profile is common in subjects with type 2 diabetes (T2D). Despite use of lipidlowering agents, many subjects with T2D do not achieve lipid targets. The present work aimed to assess lipid profile in a randomly selected group of adult diabetic subjects under treatment in order to determine how diabetes treatment affects blood lipid parameters levels. HbA1c level is used as a biomarker of glycaemia control achievement and treatment success in diabetic. Methods: This study was carried out as a pre-post test design study with a control group. A total of 117 diabetic subjects under treatment and 100 non-diabetics as control subjects are included in the study. TC, TG and HDL-C were measured by enzymatic methods and LDL-C was determined by Friedewald formula. Plasma glucose was measured by Glucose Oxidase method and glycated hemoglobin (HbA1c) with a radioimmunoassay. Results:The results showed that TC (p<0.001), LDLc (p<0.001) and TG (p=0.02) levels increased significantly in diabetics compared to controls. Atherogenic indices TC/HDL-C (p<0.01) and LDL-C/HDL-C (p<0.01), and blood calcium level (p<0.001) were significantly increased in diabetics than in controls. Subjects with HbA1c value >7.0% had significantly higher levels of TC (P<0.01), LDL-C (p<0.05), TC/HDL-C (p<0.01), LDL-C/HDL-C (p=0.02), TG/HDL-C (p=0.01) and calcemia (p<0.001) compared to subjects with HbA1c ≤7.0%. Conclusion: Significant difference of lipid parameters was observed in diabetics with HbA1c ≤7.0% and >7.0%. Abnormal lipid patterns and insulin resistance tend to be normalized with therapy of diabetes.

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Section: Discussionsupporting

confidence: 71%

Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin

Akpovi

Segbo

Marc

et al. 2015

Int Jour of Biomed Res

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“…Characteristic reflections of β-cell defects include disruption of the normal basal oscillatory pattern of insulin release, reduced or absent first phase insulin secretion in response to intravenous (IV) glucose (and with time reduced second phase release), reduced insulin response to a mixed-meal, and insufficient conversion of proinsulin to insulin. The other cells of the islets remain intact (Alsahli and Gerich, 2010). Type 2 is a polygenic disease, and many genetic variants contribute to the susceptibility of the disease.…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 99%

“…Amyloid derives from islet amyloid polypeptide (IAPP), which is co-secreted from the β-cell with insulin. Either the mature insoluble amyloid fibrils lying outside the β-cell or, more likely, small oligomers within the cell may contribute to the progressive β-cell damage (Alsahli and Gerich, 2010).…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 99%

Feline Diabetes Mellitus

Reusch

2015

Canine and Feline Endocrinology

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“…The two have been identified as risk factors for incidence of diabetes in many cross-sectional and longitudinal studies [2,3]. On the other hand, there had been no previous study in which the population-attributable fraction (PAF), an estimate of population-based risk, of IIS and IR for incidence of diabetes had been calculated in any ethnic groups, including Japanese.…”

Section: Iismentioning

confidence: 99%