Abnormalities of GPIb and GPIIb/IIIa Platelet Surface Glycoproteins in Adult and Paediatric Renal Transplant Patients

Anti-inflammatory effects of clopidogrel intake in renal transplant patients: Effects on platelet-leukocyte interactions, platelet CD40 ligand expression, and proinflammatory biomarkers

“…Although the incidences of hypertension and diabetes mellitus increase with time after transplantation, 13 these risk factors alone do not explain the high mortality rate from this cause. Immunosuppressant agents have been suggested as an additional factor for cardiovascular disease in renal transplant patients 14 , 15 . For the last 3 decades, cyclosporine (INN, ciclosporin) has had an established role in immunosuppression but also contributes to cardiovascular risk because of its hypertensive and hyperlipidemic effects 16 .…”

Immunosuppressive therapy regimen and platelet activation in renal transplant patients

“…The role of the immunosuppressant agent as an additional risk factor for thrombotic events and atherosclerosis has therefore been discussed. [5][6][7][8][9] Investigations of the hemostatic system during cyclosporine (INN, ciclosporin)-based therapy showed increased levels of plasminogen activator inhibitor, fibrinogen, 5,6 and von Willebrand factor. 7 Platelet function studies have shown that the numbers of activated glycoprotein (GP) IIb/IIIa receptors-a platelet receptor that enables aggregation by the cross-linking of fibrinogen-are increased in renal transplant patients treated with cyclosporine.…”

“…7 Platelet function studies have shown that the numbers of activated glycoprotein (GP) IIb/IIIa receptors-a platelet receptor that enables aggregation by the cross-linking of fibrinogen-are increased in renal transplant patients treated with cyclosporine. 8,9 Reduction of fibrinolytic factors and activation of platelets may therefore shift the balance of the hemostatic system toward a prothrombotic state.…”