Abnormalities of fundus autofluorescence in central serous retinopathy

Rückmann, A von; Fitzke, F.W.; Fan, Joseph; Halfyard, Anthony S; Bird, Alan C.

doi:10.1016/s0002-9394(02)01428-9

Cited by 110 publications

(81 citation statements)

References 7 publications

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“…14 The presence of hyperfluorescence in areas with subretinal fluid corroborates the same finding in active stages of acute central serous retinopathy (CSR) due to increased metabolic activity of the RPE. 11 Furthermore, this study shows that choroidal melanomas develop increased FAF shortly after treatment, mostly due to an increase in the amount of orange pigment (lipofuscin) and hyperpigmentation.…”

Section: Discussionmentioning

confidence: 57%

“…8,10 Active stages of acute central serous retinopathy (CSR) show an increase in FAF corresponding to increased metabolic activity of the retinal pigment epithelium (RPE), while chronic CSR shows decreased FAF probably due to the reduced metabolic activity of the RPE secondary to photoreceptor cell loss. 11 In pseudoxanthoma elasticum and atrophic ARMD, atrophy of the RPE is associated with decreased FAF. 12,13 FAF has also been used to study the success of selective RPE destruction by laser treatment.…”

Section: Introductionmentioning

confidence: 99%

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Changes in fundus autofluorescence of choroidal melanomas following treatment

Amselem

Pulido

Günduz

et al. 2007

Eye

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Purpose We have previously shown that fundus autofluorescence (FAF) associated with pigmented choroidal lesions can be attributed to mainly lipofuscin (orange pigment) but also to hyperpigmentation, drusen, or fibrous metaplasia. The purpose of this study is to describe the effects of treatment on FAF in choroidal melanomas after plaque radiotherapy alone or in combination with transpupillary thermotherapy (TTT). Methods Retrospective chart review of eight consecutive patients with choroidal melanoma treated with plaque radiotherapy alone or in combination with TTT who underwent FAF photography before and after treatment. The correlation between FAF patterns and foci of orange pigment, hyperpigmentation, drusen, or fibrous metaplasia was evaluated. Results The median follow-up time was 4 (range 2-9) months. Foci of orange pigment and hyperpigmentation became larger and more numerous after treatment. Fibrous metaplasia was also increased. A complete correlation between increased FAF and orange pigment was found in all eight tumours (100%) before and after treatment. No correlation between hyperpigmentation and increased FAF was found before treatment but a partial correlation was found in all eyes after treatment. Before treatment, correlation between fibrous metaplasia was present in three eyes and increased FAF was partial in two eyes with no correlation in one case. After treatment, this correlation was partial in all presenting eyes (7). Conclusions Following treatment, choroidal melanomas may show increased FAF, mainly due to an increase in the amount of lipofuscin (orange pigment) and hyperpigmentation.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Changes in fundus autofluorescence of choroidal melanomas following treatment

Amselem

Pulido

Günduz

et al. 2007

Eye

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“…Von Rückmann ve ark. 16 SSKR'de sızıntı noktalarını hiperotofloresans olarak açıklamışlar ve sızıntı noktalarının hiperotofloresans olmasını RPE yakınındaki artmış metabolik aktiviteye bağlı lipofusin birikimine bağlamışlardır. Eandi ve ark.…”

Section: Discussionunclassified

“…14,15 Bu non-invaziv yöntem hastalığın akut ve kronik safhalarında otofloresansın dağılımını ve yoğunluğundaki değişimleri ortaya koyduğundan SSKR tanısında ve hastalığın akut ya da kronik safha ayrımında ek tanı aracı olarak kullanılmaktadır. 16,17 Biz bu çalışmada akut ve kronik SSKR hastalarında tespit edilen seröz retina dekolmanı, subretinal depozit, sızıntı noktası, pigment epitel dekolmanı gibi lezyonların, FOF, OKT ve FFA bulgularını değerlendirmeyi amaçladık. …”

Section: Introductionunclassified

Akut ve Kronik Santral Seröz Koryoretinopatide Fundus Otofloresansı

Erol¹,

Özdemir²,

Turgut³

et al. 2013

Tjo

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ÖzetAmaç: Akut ve kronik santral seröz koryoretinopati (SSKR) hastalarında, fundus otofloresansı (FOF) bulgularını değerlendirmek. Ge reç ve Yön tem: Sekiz kadın, 28 erkek toplam 36 hastanın 40 gözü retrospektif olarak incelendi. Yakınmaları 6 aydan kısa süreli olan gözler akut SSKR, 6 aydan uzun süren gözlerse kronik SSKR olarak iki gruba ayrıldı. Hastalara tam oftalmolojik muayene yapıldı. OKT'de retina kalınlığına, pigment epitel dekolmanına (PED) ve subretinal depozitlere bakıldı. Sızıntı noktaları ve seröz retina dekolmanı alanları FOF görüntülemede hipootofloresans veya hiperotofloresans olarak sınıflandırıldı. Ma te ri al and Met hod:A total of 40 eyes of 36 patients (8 females, 28 males) were analyzed retrospectively. The patients were divided into two groups as acute CSC when the complaints lasted less than six months and as chronic CSC for complaints of more than six months' duration. Complete ophthalmologic examination was performed. Retinal thickness, pigment epithelium detachment (PED), and subretinal deposits were analyzed using OCT. Leakage points and serous retinal detachment were classified as hypoautofluorescence or hyperautofluorescence on FAF imaging. Re sults: The number of eyes with acute CSC was 21 (52.5%), and the number of eyes with chronic CSC was 19 (47.5%). The average retinal thickness was 422.14±99.6 microns in acute CSC eyes and 383.6±104.1 microns in chronic CSC eyes (p=0.240). We detected PED in 11 eyes and subretinal deposits in 21 eyes. The leakage points of all eyes showed hyperfluorescence in FFA. On FAF imaging, 33 leakage points demonstrated hypoautofluorescence and 7 leakage points showed hyperautofluorescence. The areas of serous retinal detachment were observed as hypoautofluorescence in 22 eyes and as hyperautofluorescence in 18 eyes. Dis cus si on: Subretinal deposits are detected mostly in chronic CSC and are observed as hyperautofluorescence on FAF imaging. (Turk J Ophthalmol 2013; 43: 94-8)

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“…11 FAF studies in acute central serous chorioretinopathy reveal increased FAF in the active stages corresponding to increased metabolic activity of the RPE, and decreased FAF in chronic stages indicating reduced metabolic activity of the RPE because of photoreceptor cell loss. 12 Hereditary retinal dystrophies usually present with increased FAF, although exceptions exist. 13,14 RPE atrophy and cell loss, as in geographic atrophy or pseudoxanthoma elasticum, have been associated with decreased FAF.…”

Section: Introductionmentioning

confidence: 99%

Review of fundus autofluorescence in choroidal melanocytic lesions

Günduz

Pulido

Ezzat

et al. 2008

Eye

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Fundus autofluorescence (FAF) imaging takes advantage of the fluorescent properties of some molecules, especially lipofuscin. FAF derives mainly from retinal pigment epithelium (RPE) and Bruch's membrane. Using confocal scanning laser ophthalmoscope (cSLO) we have previously shown that FAF associated with pigmented choroidal lesions can be attributed to mainly lipofuscin (orange pigment) within the RPE. Other causes of FAF include hyperpigmentation, drusen, or fibrous metaplasia probably because they also cause lipofuscin accumulation in the overlying RPE. There is a total or partial correlation between FAF and the foci of lipofuscin and hyperpigmentation in about 90% of the cases. The FAF patterns of choroidal melanocytic lesions were classified as patchy or diffuse. The patchy pattern was defined as the presence of distinct areas of increased FAF between areas of normal autofluorescence. The diffuse pattern was characterized by the presence of increased FAF with indistinct borders over a larger part (450%) of the tumour in the absence of such intervening areas. Choroidal melanomas presented with either a diffuse or patchy pattern, whereas choroidal naevi demonstrated only the patchy pattern. Diffuse FAF pattern was more often associated with larger choroidal melanomas as well as with early venous and late hyperfluorescence on fluorescein angiography. Limitations of these observations depend on the field of depth of cSLO; thus, FAF from other planes could not be detected. Increased retinal thickness, intraretinal oedema, or presence of subretinal fluid may also affect the FAF signal.

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Abnormalities of fundus autofluorescence in central serous retinopathy

Cited by 110 publications

References 7 publications

Changes in fundus autofluorescence of choroidal melanomas following treatment

Changes in fundus autofluorescence of choroidal melanomas following treatment

Akut ve Kronik Santral Seröz Koryoretinopatide Fundus Otofloresansı

Review of fundus autofluorescence in choroidal melanocytic lesions

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