Abnormalities in serum copper and iron concentrations in porphyria cutanea tarda patients and their relationships with other parameters

Dąbrowska, E; Jabłońska-Kaszewska, I; Łukasiak, Jerzy; Dorosz, Agnieszka; Falkiewicz, Bogdan

doi:10.1002/biof.5520110140

Cited by 2 publications

(4 citation statements)

References 3 publications

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“…The low serum iron level in hepatoma is characteristic of the disease, as was found earlier [4]. The level of serum copper is usually elevated in cirrhosis, either with or without hepatocellular carcinoma [6] (as we confirmed in 4 patients with HCC without PCT), and in PCT without HCC [1], but was relatively low (within normal values) in our patients before the development of HCC. The mean copper/iron ratio was higher than normal in the HCC without PCT groups, and lower than normal in our patients.…”

Section: Discussionsupporting

confidence: 87%

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Serum iron and copper and their relations to hepatocellular carcinoma in porphyria cutanea tarda and hemochromatosis patients — case report

et al. 2000

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Section: Discussionsupporting

confidence: 87%

“…Some biochemical results obtained in patients investigated(1)(2)(3), as compared with those in a group of four patients with HCC but without PCT, and with normal values serum alanine transferase activity; AST = serum aspartate transferase activity, Cu/Fe ratio = serum Cu/Fe ratio.…”

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confidence: 99%

Serum iron and copper and their relations to hepatocellular carcinoma in porphyria cutanea tarda and hemochromatosis patients — case report

et al. 2000

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“…As a result, copper is typically found in large quantities within the liver (Beck et al, 1997;Fuentealba and Aburto, 2003). Elevations in tissue or body fluid copper have been associated with various forms of liver disease in other species, including hepatitis, hepatic necrosis, cirrhosis, biliary cirrhosis, hepatic lipidosis, porphyria cutanea tarda, Wilson's disease, and cholestatic liver disease (Fredricks et al, 1960;Pramoolsinsap et al, 1994;Van Gossum and Neve, 1998;Noaker et al, 1999;Dabrowska et al, 2000;Thornburg, 2000;Webb et al, 2002;Fuentealba and Aburto, 2003;Halifeoglu et al, 2004;Cesur et al, 2005). To our knowledge, direct associations between changes in copper and liver disease have not been documented in bottlenose dolphins.…”

Section: Copper Associationsmentioning

confidence: 92%

“…Interestingly, the opposite has been documented when measuring serum versus whole blood iron. Dabrowska et al (2000) reported an increase in serum iron associated with an increase of ALT in porphyria cutanea tarda patients, a disease similar to hemochroma-tosis. Johnston (1999), however, reported a decrease in plasma iron associated with an increase of ALT in asymptomatic liver disease patients.…”

Section: Iron Associationsmentioning

confidence: 98%

Trace and Non-Trace Elements in Blood Cells of Bottlenose Dolphins (Tursiops Truncatus): Variations With Values From Liver Function Indicators

Sorensen

Venn‐Watson

Ridgway

2008

Journal of Wildlife Diseases

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Alterations in trace and non-trace element homeostasis have been associated with both normal physiologic and pathologic processes of many species. Changes in copper and zinc, for instance, have been associated with liver disease in humans and dogs. While liver disease has been documented in marine mammals, associations of liver disease with trace and non-trace elements have not been determined. The goal of this study was to assess potential elemental associations with clinically relevant changes in liver enzymes of bottlenose dolphins (Tursiops truncatus) and to compare observed associations to what has been reported in other species. Blood cell samples were collected from 37 healthy bottlenose dolphins, maintained by the Navy Marine Mammal Program (MMP), between 1991 and 1992. Twenty-one trace and non-trace elements were assessed along with a standard liver enzyme function profile, and trace element associations to specific liver enzymes were determined. In this study, of the 21 blood cell elements assessed, 19 were measured within detectable limits in at least one of the blood samples, and 10 trace elements were found to be associated with at least one of the liver function indicators. Many of these same associations have been documented in various forms of liver disease in other species, including the associations of increases in copper and decreases in zinc with both elevated alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT). The observed analogous associations between changes in blood trace and non-trace elements and liver function indicators of bottlenose dolphins and other species may indicate similar pathologic processes and functions of some elements. Given the results of this study, additional research is warranted to further elucidate associations of trace and non-trace elements to liver disease in bottlenose dolphins.

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Abnormalities in serum copper and iron concentrations in porphyria cutanea tarda patients and their relationships with other parameters

Cited by 2 publications

References 3 publications

Serum iron and copper and their relations to hepatocellular carcinoma in porphyria cutanea tarda and hemochromatosis patients — case report

Serum iron and copper and their relations to hepatocellular carcinoma in porphyria cutanea tarda and hemochromatosis patients — case report

Trace and Non-Trace Elements in Blood Cells of Bottlenose Dolphins (Tursiops Truncatus): Variations With Values From Liver Function Indicators

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