Abnormalities in Itch Sensation and Skin Barrier Function in Atopic NC/Tnd Mice

Amagai, Yosuke; Matsuda, Hiroshi; Tanaka, Akane

doi:10.1248/bpb.b13-00333

Cited by 10 publications

(9 citation statements)

References 27 publications

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“…Atopy patch test reactions in dogs mimic naturally occurring lesions and are very similar to what is reported in human medicine [45]. AD type lesions may be experimentally induced in mice, but this species does not spontaneously develop the disease and the experimental models only reproduce limited aspects of the disease [46] and recent literature has questioned the value of mouse models [47] as mice appear to only reproduce a very simplistic approach to allergies as a Th2 mediated disease and fail to reproduce more complex aspects of the human condition [48]. Dogs, on the other hand, are genetically closer to people, they are spontaneously affected by AD, and they also share the same environment with their owners constituting a precious and better tool to fully understand this complex disease in people.…”

Section: Atopic Dermatitis: Comparative Observationssupporting

confidence: 70%

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

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Allergic diseases have great impact on the quality of life of both people and domestic animals. They are increasing in prevalence in both animals and humans, possibly due to the changed lifestyle conditions and the decreased exposure to beneficial microorganisms. Dogs, in particular, suffer from environmental skin allergies and develop a clinical presentation which is very similar to the one of children with eczema. Thus, dogs are a very useful species to improve our understanding on the mechanisms involved in people's allergies and a natural model to study eczema. Animal models are frequently used to elucidate mechanisms of disease and to control for confounding factors which are present in studies with patients with spontaneously occurring disease and to test new therapies that can be beneficial in both species. It has been found that drugs useful in one species can also have benefits in other species highlighting the importance of a comprehensive understanding of diseases across species and the value of comparative studies. The purpose of the current article is to review allergic diseases across species and to focus on how these diseases compare to the counterpart in people.

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Section: Atopic Dermatitis: Comparative Observationssupporting

confidence: 70%

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

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“…Of further importance, oral administration of the TRPV1 antagonist PAC‐14028 in an experimentally‐induced model of atopic dermatitis (AD) in mice strikingly improved the AD‐like systemic and local symptoms (Yun et al ., ). Recently, it has been reported that the TRPV1 response to capsaicin stimulation is decreased and scratching behaviour evoked by non‐histaminergic itch inducers impaired in NC/Tnd mice with spontaneously developed AD‐like skin lesions (Amagai et al ., ). Furthermore, genetic deletion of TRPV1 in mice leads to an increased susceptibility of the animals to skin tumour formation (Bode et al ., ), which indicates that TRPV1 have a protective role against cutaneous malignant transformation and carcinogenesis.…”

Section: Trpv1mentioning

confidence: 97%

TRP channels in the skin

Tóth

Oláh

Szöllősi

et al. 2014

British J Pharmacology

105

107

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Emerging evidence suggests that transient receptor potential (TRP) ion channels not only act as 'polymodal cellular sensors' on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous TRP channels in the regulation of the skin barrier, skin cell proliferation and differentiation, and immune functions. Moreover, we also describe the putative involvement of several TRP channels in the development of certain skin diseases and identify future TRP channel-targeted therapeutic opportunities. LINKED ARTICLESThis article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-10 Abbreviations 5-HT, 5-hydroxytryptamine (serotonin); AD, atopic dermatitis; AHA, α-hydroxyl acid; ATP, adenosine 5'-triphosphate; BCC, basal cell carcinoma; BTCT, N-(4-t-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide; CGRP, calcitonin gene-related peptide; DAR, Darier's disease; HF, hair follicle; IL, interleukin; KO, knockout; NO, nitrogen monoxide; ORS, outer root sheath; OS, Olmstead syndrome; PGE2, prostaglandine E2; SERCA, sarco/endoplasmic reticulum Ca 2+ -ATPase; SP, substance P; SSC, squamous cell carcinoma; TCA, trichloroacetic acid; TE, tumour-enriched; TGFβ2, transforming growth factor β2; TRP, transient receptor potential; TRPA, transient receptor potential ankyrin; TRPC, transient receptor potential cannonical; TRPM, transient receptor potential melastatin; WS12, (1R*,2S*)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamideThe skin is one of the largest organs of the human body; therefore, it exhibits a plethora of physiological and homeostatic regulatory mechanisms (see reviewed in Bukowskiy, 2009;Draelos and Pugliese, 2011;Oláh et al., 2012). Indeed, the skin (i) establishes and maintains the first line defence of the organism against various forms of physical, chemical, and biological harmful stimuli and challenges (barrier functions); (ii) is a highly active neuro-immuno-endocrine organ (actually, the skin and the nervous system have the same embryological origin; see Makrantonaki et al., 2010) as: the skin-localized sensory afferents are involved in the neuronal processing of multiple sensory modalities (e.g. pain, itch, touch, thermosensation); it functionally expresses all major humoral and cellular components of the innate and adaptive immunity ('skin immune system'); it is not only the target but also the source of several hormonal systems (e.g. vitamin D family, hypothalamic-pituitaryadrenal and hypothalamic-pituitary -thyroid axis hormones; Zouboulis, 2004;2009b); (iii) also maintains proper motor (e.g. piloerection, vasoregulation), exocrine (e.g. sw...

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“…These findings give further credence to the PAC-14028 trials. Somewhat confusingly, in NC/Tnd mice, another model of human atopic dermatitis, the stimulation of TRPV1, but not the blockade, relieved the scratching behavior (Amagai et al, 2013).…”

Section: Dietary Mgmentioning

confidence: 99%